Kit receptor signaling pathway (WP407)

Mus musculus

Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath


Akhilesh Pandey , Alex Pico , Daniela Digles , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Mus musculus



Pathway Ontology

Stem Cell Factor signaling pathway


Label Type Compact URI Comment
Grb7 GeneProduct ncbigene:14786
Pik3r1 GeneProduct ncbigene:18708
Pik3r2 GeneProduct ncbigene:18709
Shc1 GeneProduct ncbigene:20416
CSF2RB GeneProduct ncbigene:12983
Grb2 GeneProduct ncbigene:14784
Socs6 GeneProduct ncbigene:54607
Socs4 GeneProduct ncbigene:67296
Socs5 GeneProduct ncbigene:56468
Cish GeneProduct ncbigene:12700
Cltc GeneProduct ncbigene:67300
Crk GeneProduct ncbigene:12928
Src GeneProduct ncbigene:20779
Plce1 GeneProduct ncbigene:74055
Jak2 GeneProduct ncbigene:16452
Grap GeneProduct ncbigene:71520
Ptpru GeneProduct ncbigene:19273
Stap1 GeneProduct ncbigene:56792
Prkca GeneProduct ncbigene:18750
Plcg1 GeneProduct ncbigene:18803
Stat1 GeneProduct ncbigene:20846
Stat5a GeneProduct ncbigene:20850
Stat5b GeneProduct ncbigene:20851
Pik3cg GeneProduct ncbigene:30955
Sh2b2 GeneProduct ncbigene:23921
Grb10 GeneProduct ncbigene:14783
Akt1 GeneProduct ncbigene:11651
Tec GeneProduct ncbigene:21682
Lyn GeneProduct ncbigene:17096
Dok1 GeneProduct ncbigene:13448
Ptpn6 GeneProduct ncbigene:15170
Ptpn11 GeneProduct ncbigene:19247
Epor GeneProduct ncbigene:13857
Rps6ka1 GeneProduct ncbigene:20111
Mitf GeneProduct ncbigene:17342
Mapk1 GeneProduct ncbigene:26413
Abl1 GeneProduct ncbigene:11350
Inpp5d GeneProduct ncbigene:16331
Fgr GeneProduct ncbigene:14191
Hck GeneProduct ncbigene:15162
Yes1 GeneProduct ncbigene:22612
Rasa1 GeneProduct ncbigene:218397
Fes GeneProduct ncbigene:14159
Crkl GeneProduct ncbigene:12929
Cbl GeneProduct ncbigene:12402
Socs1 GeneProduct ncbigene:12703
Vav1 GeneProduct ncbigene:22324
Vav2 GeneProduct ncbigene:22325
Matk GeneProduct ncbigene:17179
Bad GeneProduct ncbigene:12015
Sos1 GeneProduct ncbigene:20662
Ep300 GeneProduct ncbigene:328572
Fyn GeneProduct ncbigene:14360
Prkcb GeneProduct ncbigene:18751
Hras1 GeneProduct ncbigene:15461
Raf1 GeneProduct ncbigene:110157
Spred2 GeneProduct ncbigene:114716
Spred1 GeneProduct ncbigene:114715
Sh3kbp1 GeneProduct ncbigene:58194
Cblb GeneProduct ncbigene:208650
Tnfrsf10b GeneProduct ncbigene:21933
Btk GeneProduct ncbigene:12229
Kit GeneProduct ncbigene:16590
Kitl GeneProduct ncbigene:17311
Kit GeneProduct ncbigene:16590
Kitl GeneProduct ncbigene:17311
Map2k1 GeneProduct ncbigene:26395
Stat3 GeneProduct ncbigene:20848
Mpdz GeneProduct ncbigene:17475
Dok1 GeneProduct ncbigene:13448