Prostaglandin and leukotriene metabolism in senescence (WP5122)
Homo sapiens
Prostaglandin pathway in senescence.
Authors
Doreen Jost , Mario Zubak , Tade Idowu , Denise Kalbe , Fruzsina Magyar , Aysegul Celik , Eric Weitz , and Egon WillighagenActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
ONTOXAnnotations
Pathway Ontology
aging pathway leukotriene metabolic pathway cellular senescence pathway prostaglandin metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| PGH2 | Metabolite | chebi:15554 | |
| dihomo-15d-PGJ2 | Metabolite | pubchem.compound:16061095 | |
| ROS | Metabolite | chebi:26523 | |
| PGI2 | Metabolite | chebi:15552 | |
| PGE2 | Metabolite | chebi:15551 | |
| TXA2 | Metabolite | chebi:15627 | |
| PGG2 | Metabolite | chebi:27647 | |
| Adrenic acid | Metabolite | chebi:53487 | |
| Arachidonic acid | Metabolite | hmdb:HMDB01043 | |
| Membrane phospholipids | Metabolite | chebi:16247 | |
| PGD2 | Metabolite | chebi:15555 | |
| cAMP | Metabolite | hmdb:HMDB00058 | |
| 15d-PGJ2 | Metabolite | chebi:34159 | |
| PGF2a | Metabolite | chebi:15553 | |
| Ca2+ | Metabolite | chebi:29108 | |
| LTB4 | Metabolite | chebi:15647 | |
| 5-HPETE | Metabolite | hmdb:HMDB11135 | |
| LTD4 | Metabolite | chebi:28666 | |
| TP53 | Metabolite | ensembl:ENSG00000141510 | |
| LTA4 | Metabolite | chebi:15651 | |
| LTE4 | Metabolite | chebi:15650 | |
| LTC4 | Metabolite | chebi:16978 | |
| PTGES | GeneProduct | ensembl:ENSG00000148344 | |
| GNAS | GeneProduct | ensembl:ENSG00000087460 | 'Gs' originally |
| IGFBP5 | GeneProduct | ensembl:ENSG00000115461 | |
| PTGER2 | GeneProduct | ensembl:ENSG00000125384 | 'EP2 (extracellular)' originally |
| PTGDS | GeneProduct | ensembl:ENSG00000107317 | |
| PTGS1 | GeneProduct | ensembl:ENSG00000095303 | 'COX-1' originally |
| MAPK11 | GeneProduct | ensembl:ENSG00000185386 | 'p38 MAPK' originally |
| PTGS2 | GeneProduct | ensembl:ENSG00000073756 | 'COX-2' originally |
| PTGDS | GeneProduct | ensembl:ENSG00000107317 | 'PGD synthase' originally |
| PTGES | GeneProduct | hgnc.symbol:PTGES | |
| PTGIS | GeneProduct | ensembl:ENSG00000124212 | 'PGI synthase' originally |
| TBXAS1 | GeneProduct | ensembl:ENSG00000059377 | 'TxA synthase' originally |
| PRXL2B | GeneProduct | uniprot:Q8TBF2 | 'PGF synthase' originally |
| PTGER1 | GeneProduct | ensembl:ENSG00000160951 | 'EP1 (extracellular)' originally |
| PTGER3 | GeneProduct | ensembl:ENSG00000050628 | 'EP3 (extracellular)' originally |
| PTGER4 | GeneProduct | ensembl:ENSG00000171522 | 'EP4 (extracellular)' originally |
| GNAI1 | GeneProduct | ensembl:ENSG00000127955 | 'Gi' originally |
| GNAQ | GeneProduct | ensembl:ENSG00000156052 | 'Gq' originally |
| ALOX5AP | GeneProduct | ensembl:ENSG00000132965 | |
| ALOX5 | GeneProduct | ensembl:ENSG00000012779 | |
| LTC4S | GeneProduct | ensembl:ENSG00000213316 | |
| LTA4H | GeneProduct | ensembl:ENSG00000111144 | |
| ALOX15B | GeneProduct | ensembl:ENSG00000179593 | |
| CDKN1A | GeneProduct | ensembl:ENSG00000124762 | 'p21' originally |
| RB1 | GeneProduct | ensembl:ENSG00000139687 | |
| ALOX15 | GeneProduct | ensembl:ENSG00000161905 | |
| SIRT1 | GeneProduct | ensembl:ENSG00000096717 | |
| ALOX12 | GeneProduct | ensembl:ENSG00000108839 | |
| HRAS | GeneProduct | ensembl:ENSG00000174775 | |
| KRAS | GeneProduct | ensembl:ENSG00000133703 | |
| NRAS | GeneProduct | ensembl:ENSG00000213281 | |
| ADCY3 | Protein | uniprot:A0A0A0MSC1 | 'Adenylate cyclase' originally |
| PLA2G4A | Protein | uniprot:P47712 | 'Cytosolic phospholipase A2' originally |
| PLC | Protein | uniprot:A0A087WT80 | |
| CYSLTR1 | Protein | uniprot:Q9Y271 |
References
- 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation. Catalano A, Rodilossi S, Caprari P, Coppola V, Procopio A. EMBO J. 2005 Jan 12;24(1):170–9. PubMed Europe PMC Scholia
- Lipoxygenase inhibitors for cancer prevention: promises and risks. Menna C, Olivieri F, Catalano A, Procopio A. Curr Pharm Des. 2010;16(6):725–33. PubMed Europe PMC Scholia
- Involvement of IGF binding protein 5 in prostaglandin E(2)-induced cellular senescence in human fibroblasts. Yang HH, Kim C, Jung B, Kim KS, Kim JR. Biogerontology. 2011 Jun;12(3):239–52. PubMed Europe PMC Scholia
- The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway. Cormenier J, Martin N, Deslé J, Salazar-Cardozo C, Pourtier A, Abbadie C, et al. Mech Ageing Dev. 2018 Mar;170:82–91. PubMed Europe PMC Scholia
- Leukotriene D4 induces cellular senescence in osteoblasts. Wei J, Chen S, Guo W, Feng B, Yang S, Huang C, et al. Int Immunopharmacol. 2018 May;58:154–9. PubMed Europe PMC Scholia
- Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase. Häfner AK, Kahnt AS, Steinhilber D. Prostaglandins Other Lipid Mediat. 2019 Jun;142:24–32. PubMed Europe PMC Scholia
- Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, et al. JCI Insight. 2019 Dec 19;4(24):e130056. PubMed Europe PMC Scholia
- Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways. Suryadevara V, Ramchandran R, Kamp DW, Natarajan V. Int J Mol Sci. 2020 Jun 15;21(12):4257. PubMed Europe PMC Scholia
- Fibroblast Senescence in Idiopathic Pulmonary Fibrosis. Lin Y, Xu Z. Front Cell Dev Biol. 2020 Nov 25;8:593283. PubMed Europe PMC Scholia
- Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis. Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, et al. Cell Metab. 2021 Jun 1;33(6):1124-1136.e5. PubMed Europe PMC Scholia