Peroxiredoxin 2 induced ovarian failure (WP4873)

Homo sapiens

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This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.

Authors

Bas Lahaije , Friederike Ehrhart , and Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

c-Jun N-terminal kinases MAPK signaling pathway

Disease Ontology

ovarian dysfunction

Participants
Query Drugst.One

Label Type Compact URI Comment
Cytochrome C Metabolite chebi:18070 Somatic
Multiple homologues found: En:ENSG00000172115;En:ENSG00000172115;
Reactive oxygen species Metabolite chebi:26523
Estradiol-17beta Metabolite chebi:16469
Progesterone Metabolite drugbank:DB00396
BAX GeneProduct ensembl:ENSG00000087088 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003873
PARP2 GeneProduct ensembl:ENSG00000129484
CYP11A1 Protein ensembl:ENSG00000140459 Mitochondrial
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9QZ82
HSD3B2 Protein ensembl:ENSG00000203859 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:E9PXG7
JNK Protein uniprot:P53779
CASP3 Protein ensembl:ENSG00000164305 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A0A1B0GRX1
STAR Protein ensembl:ENSG00000147465 Mitichondrial
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Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P51557
Peroxiredoxin-2 Protein uniprot:P32119 No homologues found for original id S:Q61171

References

  1. Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice. Park SJ, Kim JH, Lee DG, Kim JM, Lee DS. Free Radic Biol Med. 2018 Aug 1;123:96–106. PubMed Europe PMC Scholia