Osteoblast signaling (WP322)

Homo sapiens

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Osteoblasts are specialized, terminally differentiated cell of mesenchymal origin. They create dense, crosslinked collagen and also specialized proteins, including osteocalcin and osteopontin. This pathway illustrates various signaling pathways in osteoblasts relevant to collagen and protein production. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP322 CPTAC Assay Portal]

Authors

Ed Hsiao , Alex Pico , Kristina Hanspers , Egon Willighagen , Daniela Digles , Martina Summer-Kutmon , Zahra Roudbari , Lotte Sevenich , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

osteoblast

Pathway Ontology

signaling pathway signaling pathway pertinent to development

Participants
Query Drugst.One

Label Type Compact URI Comment
Vitamin D Metabolite hmdb:HMDB0000876
Vitamin D Metabolite hmdb:HMDB0000876
Na+ Metabolite chebi:29101
Na+ Metabolite chebi:29101
Phosphate Metabolite pubchem.compound:1061
PDGF Ra GeneProduct ncbigene:5156
PDGF Rb GeneProduct ncbigene:5155
Parathyroid hormone Protein ncbigene:5741
Osteoprotegerin Protein ncbigene:4982
RANK ligand Protein ncbigene:8600
PDGFB Protein ncbigene:5155
Bone sialoprotein Protein ncbigene:3381
PDGFB Protein ncbigene:5155
PDGFRB Protein ncbigene:5159
Bone sialoprotein Protein ncbigene:3381
Soluble RANK ligand Protein ncbigene:8600
ITGAV Protein ncbigene:3685
PTH receptor Protein ncbigene:5745
FGF-23 Protein ncbigene:8074
Collagen 1 Protein ncbigene:1277
FGF-23 Protein ncbigene:8074
ITGB3 Protein ncbigene:3690
PTH receptor Protein ncbigene:5745
PDGFRA Protein ncbigene:5156
Parathyroid hormone Protein ncbigene:5741
NPT3 Protein ncbigene:10246
Osteoprotegerin Protein ncbigene:4982
Osteocalcin Protein ncbigene:632
PDGFB Protein ncbigene:5155
PDGFB Protein ncbigene:5155

References