Vitamin A and carotenoid metabolism (WP716)

Homo sapiens

This pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some additional entities (see Waagmeester et al. 2009 []).


Andra Waagmeester , Paolo Romano , Alex Pico , Chris Evelo , Susan Coort , Thomas Kelder , Kristina Hanspers , Allan Kuchinsky , Anwesha Bohler , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Zahra Roudbari , Friederike Ehrhart , Denise Slenter , Eric Weitz , and Conroy lipids


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Homo sapiens




Pathway Ontology

retinol metabolic pathway metabolic pathway of cofactors, vitamins, nutrients vitamin A and metabolites signaling pathway

Cell Type Ontology



Label Type Compact URI Comment
Betacarotene Metabolite hmdb:HMDB0000561
RetinolVitamin A Metabolite hmdb:HMDB0000305
4-oxo-13,14-dihydroretinoic acid Metabolite lipidmaps:LMPR01090068
11-cis-Retinol Metabolite hmdb:HMDB0006216
all-trans RetinolVitamin A Metabolite hmdb:HMDB0000305
4-oxo-Retinoic acid Metabolite hmdb:HMDB0006285
Beta-Cryptoxanthin Metabolite hmdb:HMDB0002268
Zeaxanthin Metabolite hmdb:HMDB0002789
Lutein Metabolite hmdb:HMDB0003233
11-cis-Retinal Metabolite hmdb:HMDB0002152
Betacarotene Metabolite hmdb:HMDB0000561
Lycopene Metabolite hmdb:HMDB0003000
Retinyl ester Metabolite hmdb:HMDB0003598
all-trans Retinal Metabolite hmdb:HMDB0001358
All-trans-13,14-dihydroretinol Metabolite lipidmaps:LMPR01090047
9-cis-Retinal Metabolite hmdb:HMDB0006218
Vitamin D3 Metabolite hmdb:HMDB0000876
all-trans Retinoic acidVitamin A acid Metabolite hmdb:HMDB0001852
Violaxanthin Metabolite hmdb:HMDB0003101
13,14 dihydroretinal Metabolite lipidmaps:LMPR01090067
Canthaxanthin Metabolite hmdb:HMDB0003154
13,14-dihydroretinoic acid Metabolite lipidmaps:LMPR01090066
9-cis-Retinoic acid Metabolite lipidmaps:LMPR01090065
Astaxanthin Metabolite hmdb:HMDB0002204
9-cis-Retinol Metabolite hmdb:HMDB0006217
Alpha-Carotene Metabolite hmdb:HMDB0003993
RetinolVitamin A Metabolite hmdb:HMDB0000305
beta 10' apocarotenal Metabolite lipidmaps:LMPR01071053
Betacarotene Metabolite hmdb:HMDB0000561
Retinyl ester Metabolite hmdb:HMDB0003598
RetinalVitamin A aldehyde Metabolite hmdb:HMDB0001358
Betacarotene Metabolite hmdb:HMDB0000561
Bcmo1 GeneProduct ncbigene:53630
Rbp7 GeneProduct ncbigene:116362
Aldh1a1 GeneProduct ncbigene:216
RARa GeneProduct ncbigene:5914
Aldh1a2 GeneProduct ncbigene:8854
Abcg8 GeneProduct ncbigene:64241
Rdh12 GeneProduct ncbigene:145226
Rdh5 GeneProduct ncbigene:5959
Dhrs3 GeneProduct ncbigene:9249
Cyp26b1 GeneProduct ncbigene:56603
Npc1l1 GeneProduct ncbigene:29881
Aldh1a3 GeneProduct ncbigene:220
Aldh1a3 GeneProduct ncbigene:220
Abcg5 GeneProduct ncbigene:64240
Lpl GeneProduct ncbigene:4023
Cyp2e1 GeneProduct ncbigene:1571
RPE65 GeneProduct ncbigene:6121
Bcdo2 GeneProduct ncbigene:83875
MAPK GeneProduct ncbigene:5594
Scarb1 GeneProduct ncbigene:949
Sult2b1 GeneProduct ncbigene:6820
Lrat GeneProduct ensembl:ENSG00000121207
RXRb GeneProduct ncbigene:6257
Rdh10 GeneProduct ncbigene:157506
Retsat GeneProduct ncbigene:54884
Rbp1 GeneProduct ncbigene:5947
Rdh12 GeneProduct ncbigene:145226
RXRa GeneProduct ncbigene:6256
Adh4 GeneProduct ncbigene:127
Sult1a1 GeneProduct ncbigene:6817
Cyp26a1 GeneProduct ncbigene:1592
Awat GeneProduct ncbigene:158835
Bcmo1 GeneProduct ncbigene:53630
Cd36 GeneProduct ncbigene:948
RARg GeneProduct ncbigene:5916
Aldh1a2 GeneProduct ncbigene:8854
Scarb1 GeneProduct ncbigene:949
Lrat GeneProduct ensembl:ENSG00000121207
Aldh1a1 GeneProduct ncbigene:216
Rdh5 GeneProduct ncbigene:5959
Rdh8 GeneProduct ncbigene:50700
Adh1 GeneProduct ncbigene:124
RXRg GeneProduct ncbigene:6258
Crabp2 GeneProduct ncbigene:1382
Crabp1 GeneProduct ncbigene:1381
Rlbp1 GeneProduct ncbigene:6017
Rbp2 GeneProduct ncbigene:5948
Bcmo1 GeneProduct ncbigene:53630
Rbp4 GeneProduct ncbigene:5950
RARb GeneProduct ncbigene:5915
Retinol dehydrogenases GeneProduct ncbigene:195814
ARAT Protein ncbigene:8694


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