Vitamin A and carotenoid metabolism (WP716)

Homo sapiens

This pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some additional entities (see Waagmeester et al. 2009 [https://www.ncbi.nlm.nih.gov/pubmed/19715393]).

Authors

Andra Waagmeester , Paolo Romano , Alex Pico , Chris Evelo , Susan Coort , Thomas Kelder , Kristina Hanspers , Allan Kuchinsky , Anwesha Bohler , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Zahra Roudbari , Friederike Ehrhart , Denise Slenter , Eric Weitz , and Conroy lipids

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Micronutrients

Annotations

Pathway Ontology

metabolic pathway of cofactors, vitamins, nutrients retinol metabolic pathway vitamin A and metabolites signaling pathway

Participants

Label Type Compact URI Comment
Betacarotene Metabolite hmdb:HMDB0000561
RetinolVitamin A Metabolite hmdb:HMDB0000305
4-oxo-13,14-dihydroretinoic acid Metabolite lipidmaps:LMPR01090068
11-cis-Retinol Metabolite hmdb:HMDB0006216
all-trans RetinolVitamin A Metabolite hmdb:HMDB0000305
4-oxo-Retinoic acid Metabolite hmdb:HMDB0006285
Beta-Cryptoxanthin Metabolite hmdb:HMDB0002268
Zeaxanthin Metabolite hmdb:HMDB0002789
Lutein Metabolite hmdb:HMDB0003233
11-cis-Retinal Metabolite hmdb:HMDB0002152
Betacarotene Metabolite hmdb:HMDB0000561
Lycopene Metabolite hmdb:HMDB0003000
Retinyl ester Metabolite hmdb:HMDB0003598
all-trans Retinal Metabolite hmdb:HMDB0001358
All-trans-13,14-dihydroretinol Metabolite lipidmaps:LMPR01090047
9-cis-Retinal Metabolite hmdb:HMDB0006218
Vitamin D3 Metabolite hmdb:HMDB0000876
all-trans Retinoic acidVitamin A acid Metabolite hmdb:HMDB0001852
Violaxanthin Metabolite hmdb:HMDB0003101
13,14 dihydroretinal Metabolite lipidmaps:LMPR01090067
Canthaxanthin Metabolite hmdb:HMDB0003154
13,14-dihydroretinoic acid Metabolite lipidmaps:LMPR01090066
9-cis-Retinoic acid Metabolite lipidmaps:LMPR01090065
Astaxanthin Metabolite hmdb:HMDB0002204
9-cis-Retinol Metabolite hmdb:HMDB0006217
Alpha-Carotene Metabolite hmdb:HMDB0003993
RetinolVitamin A Metabolite hmdb:HMDB0000305
beta 10' apocarotenal Metabolite lipidmaps:LMPR01071053
Betacarotene Metabolite hmdb:HMDB0000561
Retinyl ester Metabolite hmdb:HMDB0003598
RetinalVitamin A aldehyde Metabolite hmdb:HMDB0001358
Betacarotene Metabolite hmdb:HMDB0000561
Bcmo1 GeneProduct ncbigene:53630
Rbp7 GeneProduct ncbigene:116362
Aldh1a1 GeneProduct ncbigene:216
RARa GeneProduct ncbigene:5914
Aldh1a2 GeneProduct ncbigene:8854
Abcg8 GeneProduct ncbigene:64241
Rdh12 GeneProduct ncbigene:145226
Rdh5 GeneProduct ncbigene:5959
Dhrs3 GeneProduct ncbigene:9249
Cyp26b1 GeneProduct ncbigene:56603
Npc1l1 GeneProduct ncbigene:29881
Aldh1a3 GeneProduct ncbigene:220
Aldh1a3 GeneProduct ncbigene:220
Abcg5 GeneProduct ncbigene:64240
Lpl GeneProduct ncbigene:4023
Cyp2e1 GeneProduct ncbigene:1571
RPE65 GeneProduct ncbigene:6121
Bcdo2 GeneProduct ncbigene:83875
MAPK GeneProduct ncbigene:5594
Scarb1 GeneProduct ncbigene:949
Sult2b1 GeneProduct ncbigene:6820
Lrat GeneProduct ensembl:ENSG00000121207
RXRb GeneProduct ncbigene:6257
Rdh10 GeneProduct ncbigene:157506
Retsat GeneProduct ncbigene:54884
Rbp1 GeneProduct ncbigene:5947
Rdh12 GeneProduct ncbigene:145226
RXRa GeneProduct ncbigene:6256
Adh4 GeneProduct ncbigene:127
Sult1a1 GeneProduct ncbigene:6817
Cyp26a1 GeneProduct ncbigene:1592
Awat GeneProduct ncbigene:158835
Bcmo1 GeneProduct ncbigene:53630
Cd36 GeneProduct ncbigene:948
RARg GeneProduct ncbigene:5916
Aldh1a2 GeneProduct ncbigene:8854
Scarb1 GeneProduct ncbigene:949
Lrat GeneProduct ensembl:ENSG00000121207
Aldh1a1 GeneProduct ncbigene:216
Rdh5 GeneProduct ncbigene:5959
Rdh8 GeneProduct ncbigene:50700
Adh1 GeneProduct ncbigene:124
RXRg GeneProduct ncbigene:6258
Crabp2 GeneProduct ncbigene:1382
Crabp1 GeneProduct ncbigene:1381
Rlbp1 GeneProduct ncbigene:6017
Rbp2 GeneProduct ncbigene:5948
Bcmo1 GeneProduct ncbigene:53630
Rbp4 GeneProduct ncbigene:5950
RARb GeneProduct ncbigene:5915
Retinol dehydrogenases GeneProduct ncbigene:195814
ARAT Protein ncbigene:8694

References

  1. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr. Anal Chem. 1992 Sep 15;64(18):2111–22. PubMed Europe PMC Scholia
  2. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Sies H, Stahl W, Sundquist AR. Ann N Y Acad Sci. 1992 Sep 30;669:7–20. PubMed Europe PMC Scholia
  3. Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, et al. Am J Clin Nutr. 1992 Jun;55(6):1120–5. PubMed Europe PMC Scholia
  4. Biological actions of carotenoids. Bendich A, Olson JA. FASEB J. 1989 Jun;3(8):1927–32. PubMed Europe PMC Scholia
  5. Interrelationships among liposoluble vitamins in ruminants. Hidiroglou M, Williams CJ. Am J Vet Res. 1986 Aug;47(8):1767–71. PubMed Europe PMC Scholia
  6. Carotenoids in the human macula and whole retina. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):850–5. PubMed Europe PMC Scholia
  7. Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E. Am J Clin Nutr. 1994 Jul;60(1):106–10. PubMed Europe PMC Scholia
  8. Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study. Boosalis MG, Snowdon DA, Tully CL, Gross MD. Nutrition. 1996;12(7–8):475–8. PubMed Europe PMC Scholia
  9. Influence of using different sources of carotenoid data in epidemiologic studies. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, et al. J Am Diet Assoc. 1996 Dec;96(12):1271–5. PubMed Europe PMC Scholia
  10. Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL. Eur J Pediatr. 1997 Dec;156(12):949–51. PubMed Europe PMC Scholia
  11. Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture. Törmä H, Rollman O, Binderup L, Michaelsson G. J Investig Dermatol Symp Proc. 1996 Apr;1(1):49–53. PubMed Europe PMC Scholia
  12. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, et al. Nutr Cancer. 1999;33(1):105–12. PubMed Europe PMC Scholia
  13. Vitamin A antagonizes calcium response to vitamin D in man. Johansson S, Melhus H. J Bone Miner Res. 2001 Oct;16(10):1899–905. PubMed Europe PMC Scholia
  14. Gene expression regulation by retinoic acid. Balmer JE, Blomhoff R. J Lipid Res. 2002 Nov;43(11):1773–808. PubMed Europe PMC Scholia
  15. Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States. Ruhl CE, Everhart JE. Gastroenterology. 2003 Jun;124(7):1821–9. PubMed Europe PMC Scholia
  16. Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue. Czeczuga-Semeniuk E, Wołczyński S, Markiewicz W. Neoplasma. 2003;50(4):280–6. PubMed Europe PMC Scholia
  17. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. Moise AR, Kuksa V, Imanishi Y, Palczewski K. J Biol Chem. 2004 Nov 26;279(48):50230–42. PubMed Europe PMC Scholia
  18. Metabolism and transactivation activity of 13,14-dihydroretinoic acid. Moise AR, Kuksa V, Blaner WS, Baehr W, Palczewski K. J Biol Chem. 2005 Jul 29;280(30):27815–25. PubMed Europe PMC Scholia
  19. Identification and characterization of a novel mouse peroxisome proliferator-activated receptor alpha-regulated and starvation-induced gene, Ppsig. Sun Y, Ng L, Lam W, Lo CKC, Chan PT, Yuen YL, et al. Int J Biochem Cell Biol. 2008;40(9):1775–91. PubMed Europe PMC Scholia
  20. Pathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism. Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D. OMICS. 2009 Oct;13(5):367–79. PubMed Europe PMC Scholia