Cholestasis (WP5238)

Homo sapiens

Cholestasis - bile flow obstruction

Authors

Velina Pencheva , Susan Coort , Friederike Ehrhart , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

cholestasis

Pathway Ontology

cholestasis pathway

Cell Type Ontology

hepatocyte

Participants

Label Type Compact URI Comment
Cations Metabolite chebi:25697
Cholesterol Metabolite chebi:16113
Na+ Metabolite chebi:29101
Ba Metabolite chebi:22868
PPAR-a Metabolite chebi:70782
Phospholipids Metabolite chebi:16247
HDL Metabolite chebi:39025
Cholesteryl esters Metabolite chebi:17002
Acetyl CoA Metabolite chebi:15351
LDL Metabolite chebi:39026
HCO3(-) Metabolite chebi:17544
GSH Metabolite chebi:16856
Bile acid Metabolite chebi:3098
Chol Metabolite chebi:16113
NR1I3 GeneProduct ensembl:ENSG00000143257
HMGCR GeneProduct uniprot:P04035
ABCG5 Protein uniprot:Q9H222
ABCG8 Protein uniprot:Q9H221
ABCB11 Protein uniprot:O95342 Bile salt export pump
NR1H4 Protein uniprot:Q96RI1 Farnesoid X Receptor
ABCC2 Protein uniprot:Q92887 Multidrug resistance-associated protein 2
mEH Protein uniprot:P07099 microsomal epoxide hydrolase
OATPs Protein uniprot:P46721 Solute carrier organic anion transporter family member
TJP2 Protein uniprot:Q9UDY2 Tight junction protein ZO-2
ABCB4 Protein uniprot:P21439 Multidrug resistance protein 3
RXRA Protein uniprot:P19793 Retinoid X receptor
ATP8B1 Protein uniprot:O43520 familial intrahepatic cholestasis 1
NTCP Protein uniprot:Q14973 sodium/bile acid cotransporter
OCT1 Protein uniprot:O15245 Organic cation transporter 1
MRP3 Protein uniprot:O15438 Multidrug resistance associated protein 3
MRP4 Protein uniprot:O15439 Multidrug resistance associated protein 4
LDLR Protein uniprot:P01130 microsomal epoxide hydrolase
SR-B1 Protein uniprot:Q8WTV0 Scavenger receptor class B member 1

References

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  3. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. Mol Endocrinol. 2003 Feb;17(2):259–72. PubMed Europe PMC Scholia
  4. Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, et al. J Hepatol. 2003 Oct;39(4):480–8. PubMed Europe PMC Scholia
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