Cholestasis (WP5238)

Homo sapiens

Authors

Velina Pencheva , Susan Coort , Friederike Ehrhart , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cholestasis pathway

Disease Ontology

cholestasis

Cell Type Ontology

hepatocyte

References

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2. Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding. Kassam A, Miao B, Young PR, Mukherjee R. J Biol Chem. 2003 Mar 21;278(12):10028–32. PubMed Europe PMC Scholia
3. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. Mol Endocrinol. 2003 Feb;17(2):259–72. PubMed Europe PMC Scholia
4. Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. Zollner G, Fickert P, Fuchsbichler A, Silbert D, Wagner M, Arbeiter S, et al. J Hepatol. 2003 Oct;39(4):480–8. PubMed Europe PMC Scholia
5. Farnesoid X receptor activates transcription of the phospholipid pump MDR3. Huang L, Zhao A, Lew JL, Zhang T, Hrywna Y, Thompson JR, et al. J Biol Chem. 2003 Dec 19;278(51):51085–90. PubMed Europe PMC Scholia
6. The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. Friesen JA, Rodwell VW. Genome Biol. 2004;5(11):248. PubMed Europe PMC Scholia
7. Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. Yu L, Gupta S, Xu F, Liverman ADB, Moschetta A, Mangelsdorf DJ, et al. J Biol Chem. 2005 Mar 11;280(10):8742–7. PubMed Europe PMC Scholia
8. Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha. Moffit JS, Aleksunes LM, Maher JM, Scheffer GL, Klaassen CD, Manautou JE. J Pharmacol Exp Ther. 2006 May;317(2):537–45. PubMed Europe PMC Scholia
9. Cholesterol sensing, trafficking, and esterification. Chang TY, Chang CCY, Ohgami N, Yamauchi Y. Annu Rev Cell Dev Biol. 2006;22:129–57. PubMed Europe PMC Scholia
10. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. Kim I, Ahn SH, Inagaki T, Choi M, Ito S, Guo GL, et al. J Lipid Res. 2007 Dec;48(12):2664–72. PubMed Europe PMC Scholia
11. The role of FXR in disorders of bile acid homeostasis. Eloranta JJ, Kullak-Ublick GA. Physiology (Bethesda). 2008 Oct;23:286–95. PubMed Europe PMC Scholia
12. Acyl-coenzyme A:cholesterol acyltransferases. Chang TY, Li BL, Chang CCY, Urano Y. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E1-9. PubMed Europe PMC Scholia
13. FIC1-mediated stimulation of FXR activity is decreased with PFIC1 mutations in HepG2 cells. Koh S, Takada T, Kukuu I, Suzuki H. J Gastroenterol. 2009;44(6):592–600. PubMed Europe PMC Scholia
14. Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter. Renga B, Migliorati M, Mencarelli A, Cipriani S, D’Amore C, Distrutti E, et al. Biochim Biophys Acta. 2011 Mar;1809(3):157–65. PubMed Europe PMC Scholia
15. Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders. Fiorucci S, Zampella A, Distrutti E. Curr Top Med Chem. 2012;12(6):605–24. PubMed Europe PMC Scholia
16. Bile acid metabolism and signaling. Chiang JYL. Compr Physiol. 2013 Jul;3(3):1191–212. PubMed Europe PMC Scholia
17. Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion. Ghonem NS, Ananthanarayanan M, Soroka CJ, Boyer JL. Hepatology. 2014 Mar;59(3):1030–42. PubMed Europe PMC Scholia
18. Bile acid nuclear receptor FXR and digestive system diseases. Ding L, Yang L, Wang Z, Huang W. Acta Pharm Sin B. 2015 Mar;5(2):135–44. PubMed Europe PMC Scholia
19. PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression. More VR, Campos CR, Evans RA, Oliver KD, Chan GN, Miller DS, et al. J Cereb Blood Flow Metab. 2017 Apr;37(4):1199–212. PubMed Europe PMC Scholia
20. Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR. Hiebl V, Ladurner A, Latkolik S, Dirsch VM. Biotechnol Adv. 2018 Nov 1;36(6):1657–98. PubMed Europe PMC Scholia
21. Thyroid hormone receptor β1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion in mice. Gautherot J, Claudel T, Cuperus F, Fuchs CD, Falguières T, Trauner M. J Lipid Res. 2018 Sep;59(9):1610–9. PubMed Europe PMC Scholia
22. Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR. Dong B, Singh AB, Guo GL, Young M, Liu J. Int J Mol Med. 2019 May;43(5):1927–38. PubMed Europe PMC Scholia