Kennedy pathway from sphingolipids (WP3933)

Homo sapiens

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The CDP-choline pathway, first identified by Eugene Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway on the left-hand side represents one half of what is known as the Kennedy pathway. The other half on the right-hand side is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid product phosphatidylethanolamine (PE). Source: [https://en.wikipedia.org/wiki/CDP-choline_pathway Wikipedia]

Authors

Kristina Hanspers , Denise Slenter , Egon Willighagen , Eric Weitz , and Lars Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

CDP-choline pathway of phosphatidylcholine biosynthesis lipid metabolic pathway phospholipid metabolic pathway CDP-choline pathway of phosphatidylcholine biosynthesis

Participants
Query Drugst.One

Label Type Compact URI Comment
Ethanolamine Metabolite kegg.compound:C00189
SAM Metabolite kegg.compound:C00019
PPi Metabolite wikidata:Q290828 PPi=pyrophosphate
Phosphocholine Metabolite chebi:18132
Sphingolipid Metabolite chebi:26739
Phosphatidylserine Metabolite kegg.compound:C02737
Phosphatidylethanolamine Metabolite kegg.compound:C00350
SAH Metabolite kegg.compound:C00021
CMP Metabolite chebi:17361
ATP Metabolite cas:1927-31-7
Phosphatidylcholines Metabolite wikidata:Q650187
Ethanolamine Metabolite kegg.compound:C00189
L-Serine Metabolite kegg.compound:C00065
ADP Metabolite cas:58-64-0
CDP-choline Metabolite kegg.compound:C00307
L-Serine Metabolite kegg.compound:C00065
Choline Metabolite kegg.compound:C00114
Choline Metabolite kegg.compound:C00114
O-Phosphoethanolamine Metabolite kegg.compound:C00346
AAG Metabolite chebi:73341
DAG Metabolite chebi:18035 DAG = diacylglycerol
CDP-Ethanolamine Metabolite kegg.compound:C00570
CTP Metabolite cas:2056-98-6
Pisd GeneProduct ensembl:ENSG00000241878 phosphatidylserine decarboxylase
CEPT1 GeneProduct ensembl:ENSG00000134255 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:99712
PEMT GeneProduct ensembl:ENSG00000133027 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18618
CHKB GeneProduct ensembl:ENSG00000100288 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651
SGPL1 GeneProduct ensembl:ENSG00000166224 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20397
PTDSS1 GeneProduct ensembl:ENSG00000156471 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19210
CHKA GeneProduct ensembl:ENSG00000110721 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12660
PCYT1B GeneProduct ensembl:ENSG00000102230 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:236899
PCYT2 GeneProduct ensembl:ENSG00000185813 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671
ETNK1 GeneProduct ensembl:ENSG00000139163 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320
PCYT1A GeneProduct ensembl:ENSG00000161217 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026
ETNK2 GeneProduct ensembl:ENSG00000143845 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:214253
CHPT1 GeneProduct ensembl:ENSG00000111666 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862
PTDSS2 GeneProduct ensembl:ENSG00000174915 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:27388

References

  1. The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. Gibellini F, Smith TK. IUBMB Life. 2010 Jun;62(6):414–28. PubMed Europe PMC Scholia
  2. Genetic diseases of the Kennedy pathways for membrane synthesis. Tavasoli M, Lahire S, Reid T, Brodovsky M, McMaster CR. J Biol Chem. 2020 Dec 18;295(51):17877–86. PubMed Europe PMC Scholia