FOXA2 pathway (WP5066)

Homo sapiens

Open in new tab Open in NDEx
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Role of Foxa2

Authors

Chesley De Windt , Egon Willighagen , Friederike Ehrhart , Kristina Hanspers , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
TAGs Metabolite chebi:17855
IRS2 GeneProduct ensembl:ENSG00000185950
FOXA2 GeneProduct ensembl:ENSG00000125798
PPARGC1B GeneProduct ensembl:ENSG00000155846
FASN GeneProduct ensembl:ENSG00000169710
GSTA1 GeneProduct ensembl:ENSG00000243955
IRS1 GeneProduct ensembl:ENSG00000169047
ABCC4 GeneProduct ensembl:ENSG00000125257
ABCC3 GeneProduct ensembl:ENSG00000108846
ABCC2 GeneProduct ensembl:ENSG00000023839
SLC27A5 GeneProduct ensembl:ENSG00000083807
SLCO1B1 GeneProduct ensembl:ENSG00000134538
FOXO1 GeneProduct ensembl:ENSG00000150907
GSTA2 GeneProduct ensembl:ENSG00000244067
FOXA1 GeneProduct ensembl:ENSG00000129514
GSTM2 GeneProduct ensembl:ENSG00000213366
MTTP GeneProduct ensembl:ENSG00000138823
FOXA2 GeneProduct ensembl:ENSG00000125798
Apolipoprotein B-100 Protein uniprot:P04114
Acetyl-CoA carboxylase 1 Protein uniprot:Q13085
ChREBP Protein uniprot:Q9NP71
SREBP-1c Protein uniprot:P36956
Insulin Protein uniprot:A6XGL2
Insulin Protein uniprot:A6XGL2

References

  1. Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Horton JD. Biochem Soc Trans. 2002 Nov;30(Pt 6):1091–5. PubMed Europe PMC Scholia
  2. Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. Wolfrum C, Besser D, Luca E, Stoffel M. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11624–9. PubMed Europe PMC Scholia
  3. Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Wolfrum C, Stoffel M. Cell Metab. 2006 Feb;3(2):99–110. PubMed Europe PMC Scholia
  4. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH. Nat Med. 2008 Aug;14(8):828–36. PubMed Europe PMC Scholia
  5. Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, et al. Mol Endocrinol. 2010 Aug;24(8):1594–604. PubMed Europe PMC Scholia