Quercetin and Nf-kB / AP-1 induced apoptosis (WP2435)

Homo sapiens

Quercetin is a flavonoid that is widely distributed in nature. In this pathway, its dual nature is depicted. On the one hand, it is capable of exerting anti-oxidant and anti-inflammatory effects by inhibiting the PLA2-induced conversion of cell membrane phospholipids to arachidonic acid, reducing the downstream synthesis of pro-inflammatory prostaglandins; furthermore, inhibition of NF-kB and AP-1 transcription factor activation also contribute to these effects. On the other hand, quercetin itself may - paraxodically - generate ROS, as well as facilitate the activation of NFE2L2, which results in the production of CYP2A6. This isotype of CYP450 was found to be involved in the formation of carcinogenic metabolites. Both of these effects culminate in DNA damage. It has been observed, however, that these pro-oxidant effects are dominant at higher concentrations, whereas anti-oxidant effects are dominant at lower concentrations. Based on this, it has been suggested that quercetin may have a scavenging effect.


Chris Boye , Alex Pico , Nuno , Zahra Roudbari , Linda Rieswijk , Marianthi Kalafati , Denise Slenter , Andika Tan , Finterly Hu , and Eric Weitz


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Homo sapiens



Pathway Ontology

regulatory pathway apoptotic cell death pathway


Label Type Compact URI Comment
Prostaglandin G2 Metabolite hmdb:HMDB0003235
Quercetin Metabolite hmdb:HMDB0005794
Prostaglandin H2 Metabolite hmdb:HMDB0001381
Arachidonic acid Metabolite hmdb:HMDB0001043
Prostaglandin I2 Metabolite hmdb:HMDB0001335
Thromboxane A2 Metabolite hmdb:HMDB0001452
Prostaglandin F2a Metabolite hmdb:HMDB0001139
Prostaglandin D2 Metabolite hmdb:HMDB0001403
Prostaglandin E2 Metabolite hmdb:HMDB0001220
COX1 GeneProduct ncbigene:4512
IKBKB GeneProduct ensembl:ENSG00000104365 Type your comment here
NFKB1 GeneProduct ensembl:ENSG00000109320
MAFK GeneProduct ncbigene:7975
Phospholipase A2 GeneProduct eccode:
MAFG GeneProduct ncbigene:4097
ACOX2 GeneProduct ensembl:ENSG00000168306
NFKBIA GeneProduct ensembl:ENSG00000100906
FOS GeneProduct ensembl:ENSG00000170345
NOS1 GeneProduct ensembl:ENSG00000089250
VEGFA GeneProduct ensembl:ENSG00000112715
NFKB1 GeneProduct ensembl:ENSG00000109320
JUN GeneProduct ensembl:ENSG00000177606
MMP1 GeneProduct ensembl:ENSG00000196611
CYP2A6 GeneProduct ensembl:ENSG00000255974 one of several possible phase 1 enzymes
NFE2L2 GeneProduct ensembl:ENSG00000116044
KEAP1 GeneProduct ensembl:ENSG00000079999
NFE2L2 GeneProduct ensembl:ENSG00000116044
NFE2L2 GeneProduct ensembl:ENSG00000116044
COX2 GeneProduct ncbigene:5743
NFKBIA Protein ensembl:ENSG00000100906


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