G protein signaling pathways (WP1165)

Canis familiaris

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]]

Authors

Thomas Kelder , Christine Chichester , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

G protein mediated signaling pathway

Participants

Label Type Compact URI Comment
IP3 Metabolite hmdb:HMDB0001143
Ca2+ Metabolite hmdb:HMDB0000464
DAG Metabolite kegg.compound:C00165
cAMP Metabolite hmdb:HMDB0000058
PRKAR2B GeneProduct ncbigene:475887
PDE7B GeneProduct ncbigene:483996
ADCY3 GeneProduct ncbigene:482994
ADCY5 GeneProduct ncbigene:403859
GNG11 GeneProduct ncbigene:610002
AKAP8 GeneProduct ncbigene:474362
PPP3CC GeneProduct ncbigene:609027
AKAP1 GeneProduct ncbigene:480567
PRKAR1B GeneProduct ncbigene:480805
GNAS GeneProduct ncbigene:403943
PRKCD GeneProduct ncbigene:494005
GNB3 GeneProduct ncbigene:403511
GNAQ GeneProduct ncbigene:403928
GNAO1 GeneProduct ncbigene:609157
PDE4D GeneProduct ncbigene:487221
PRKCB GeneProduct ncbigene:489968
RRAS GeneProduct ncbigene:476413
GNA14 GeneProduct ncbigene:484156
AKAP5 GeneProduct ncbigene:480354
GNAZ GeneProduct ncbigene:607445
ADCY4 GeneProduct ncbigene:480271
PDE8B GeneProduct ncbigene:488939
NRAS GeneProduct ncbigene:403872
LOC611349 GeneProduct ncbigene:611349
GNGT1 GeneProduct ncbigene:403895
GNB2 GeneProduct ncbigene:479733
PRKAR1A GeneProduct ncbigene:480459
GNA11 GeneProduct ncbigene:403914
PRKCH GeneProduct ncbigene:490722
PPP3CA GeneProduct ncbigene:403486
GNAI1 GeneProduct ncbigene:478227
CALM1 GeneProduct ncbigene:480416
PRKACB GeneProduct ncbigene:479975
PRKAR2A GeneProduct ncbigene:484774
GNB5 GeneProduct ncbigene:608623
KCNJ3 GeneProduct ncbigene:488355
PLCB3 GeneProduct ncbigene:476034
AKAP7 GeneProduct ncbigene:484128
GNA13 GeneProduct ncbigene:490901
Adcy6 GeneProduct ncbigene:477625
AKAP3 GeneProduct ncbigene:477719
PDE1A GeneProduct ncbigene:403652
PDE1C GeneProduct ncbigene:475272
ADCY2 GeneProduct ncbigene:478624
GNAO1 GeneProduct ncbigene:609157
GNAL GeneProduct ncbigene:607658
PRKD1 GeneProduct ncbigene:609091
PRKD3 GeneProduct ncbigene:483036
ADCY9 GeneProduct ncbigene:490031
AKAP6 GeneProduct ncbigene:490644
PPP3CC GeneProduct ncbigene:609027
AKAP13 GeneProduct ncbigene:479032
GNA15 GeneProduct ncbigene:485063
PDE8A GeneProduct ncbigene:488752
AKAP12 GeneProduct ncbigene:476246
RHOA GeneProduct ncbigene:403954
AKAP4 GeneProduct ncbigene:480917
GNAI3 GeneProduct ncbigene:611810
AKAP11 GeneProduct ncbigene:609431
GNGT2 GeneProduct ncbigene:403617
PRKCQ GeneProduct ncbigene:478013
PDE4C GeneProduct ncbigene:609938
GNG8 GeneProduct ncbigene:484428
PRKCE GeneProduct ncbigene:609934
GNG7 GeneProduct ncbigene:612139
PRKCG GeneProduct ncbigene:484316
GNB1 GeneProduct ncbigene:403912
PRKCA GeneProduct ncbigene:490904
PRKCI GeneProduct ncbigene:478686
GNG3 GeneProduct ncbigene:483783
PRKCZ GeneProduct ncbigene:479577
AKAP10 GeneProduct ncbigene:609073
GNAI1 GeneProduct ncbigene:478227
ADCY8 GeneProduct ncbigene:482045
ADCY7 GeneProduct ncbigene:487289
PRKACA GeneProduct ncbigene:403556
PDE4B GeneProduct ncbigene:479540
HRAS GeneProduct ncbigene:403735
PDE7A GeneProduct ncbigene:486975
AKAP9 GeneProduct ncbigene:475224
GNG4 GeneProduct ncbigene:607513
GNA12 GeneProduct ncbigene:609567
ITPR1 GeneProduct ncbigene:476548
SLC9A1 GeneProduct ncbigene:478171
GNAI2 GeneProduct ncbigene:442957

References

  1. G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
  2. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia