G protein signaling pathways (WP1165)

Canis familiaris

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]]


Thomas Kelder , Christine Chichester , and Eric Weitz


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Canis familiaris



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
IP3 Metabolite hmdb:HMDB0001143
Ca2+ Metabolite hmdb:HMDB0000464
DAG Metabolite kegg.compound:C00165
cAMP Metabolite hmdb:HMDB0000058
PRKAR2B GeneProduct ncbigene:475887
PDE7B GeneProduct ncbigene:483996
ADCY3 GeneProduct ncbigene:482994
ADCY5 GeneProduct ncbigene:403859
GNG11 GeneProduct ncbigene:610002
AKAP8 GeneProduct ncbigene:474362
PPP3CC GeneProduct ncbigene:609027
AKAP1 GeneProduct ncbigene:480567
PRKAR1B GeneProduct ncbigene:480805
GNAS GeneProduct ncbigene:403943
PRKCD GeneProduct ncbigene:494005
GNB3 GeneProduct ncbigene:403511
GNAQ GeneProduct ncbigene:403928
GNAO1 GeneProduct ncbigene:609157
PDE4D GeneProduct ncbigene:487221
PRKCB GeneProduct ncbigene:489968
RRAS GeneProduct ncbigene:476413
GNA14 GeneProduct ncbigene:484156
AKAP5 GeneProduct ncbigene:480354
GNAZ GeneProduct ncbigene:607445
ADCY4 GeneProduct ncbigene:480271
PDE8B GeneProduct ncbigene:488939
NRAS GeneProduct ncbigene:403872
LOC611349 GeneProduct ncbigene:611349
GNGT1 GeneProduct ncbigene:403895
GNB2 GeneProduct ncbigene:479733
PRKAR1A GeneProduct ncbigene:480459
GNA11 GeneProduct ncbigene:403914
PRKCH GeneProduct ncbigene:490722
PPP3CA GeneProduct ncbigene:403486
GNAI1 GeneProduct ncbigene:478227
CALM1 GeneProduct ncbigene:480416
PRKACB GeneProduct ncbigene:479975
PRKAR2A GeneProduct ncbigene:484774
GNB5 GeneProduct ncbigene:608623
KCNJ3 GeneProduct ncbigene:488355
PLCB3 GeneProduct ncbigene:476034
AKAP7 GeneProduct ncbigene:484128
GNA13 GeneProduct ncbigene:490901
Adcy6 GeneProduct ncbigene:477625
AKAP3 GeneProduct ncbigene:477719
PDE1A GeneProduct ncbigene:403652
PDE1C GeneProduct ncbigene:475272
ADCY2 GeneProduct ncbigene:478624
GNAO1 GeneProduct ncbigene:609157
GNAL GeneProduct ncbigene:607658
PRKD1 GeneProduct ncbigene:609091
PRKD3 GeneProduct ncbigene:483036
ADCY9 GeneProduct ncbigene:490031
AKAP6 GeneProduct ncbigene:490644
PPP3CC GeneProduct ncbigene:609027
AKAP13 GeneProduct ncbigene:479032
GNA15 GeneProduct ncbigene:485063
PDE8A GeneProduct ncbigene:488752
AKAP12 GeneProduct ncbigene:476246
RHOA GeneProduct ncbigene:403954
AKAP4 GeneProduct ncbigene:480917
GNAI3 GeneProduct ncbigene:611810
AKAP11 GeneProduct ncbigene:609431
GNGT2 GeneProduct ncbigene:403617
PRKCQ GeneProduct ncbigene:478013
PDE4C GeneProduct ncbigene:609938
GNG8 GeneProduct ncbigene:484428
PRKCE GeneProduct ncbigene:609934
GNG7 GeneProduct ncbigene:612139
PRKCG GeneProduct ncbigene:484316
GNB1 GeneProduct ncbigene:403912
PRKCA GeneProduct ncbigene:490904
PRKCI GeneProduct ncbigene:478686
GNG3 GeneProduct ncbigene:483783
PRKCZ GeneProduct ncbigene:479577
AKAP10 GeneProduct ncbigene:609073
GNAI1 GeneProduct ncbigene:478227
ADCY8 GeneProduct ncbigene:482045
ADCY7 GeneProduct ncbigene:487289
PRKACA GeneProduct ncbigene:403556
PDE4B GeneProduct ncbigene:479540
HRAS GeneProduct ncbigene:403735
PDE7A GeneProduct ncbigene:486975
AKAP9 GeneProduct ncbigene:475224
GNG4 GeneProduct ncbigene:607513
GNA12 GeneProduct ncbigene:609567
ITPR1 GeneProduct ncbigene:476548
SLC9A1 GeneProduct ncbigene:478171
GNAI2 GeneProduct ncbigene:442957


  1. G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
  2. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia