Suzetrigine mechanism for pain relief (WP5558)

Homo sapiens

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Suzetrigine (trade name Journavx) is an oral medication used to manage moderate to severe acute pain. It is a non-opioid, small-molecule analgesic that functions by selectively inhibiting Nav1.8-dependent pain signaling pathways in the peripheral nervous system. Unlike opioids, suzetrigine is non-addictive. Inspired by Figure 2 in Cho et al. (2025).

Authors

Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

peripheral sensory neuron sensory neuron of dorsal root ganglion pain receptor cell

Pathway Ontology

drug pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Na+ Metabolite chebi:29101
Suzetrigine Metabolite drugbank:DB18927
SCN10A GeneProduct ensembl:ENSG00000185313

References