Synthesis and degradation of ketone bodies (WP101)

Drosophila melanogaster

Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]


Niradiz Reyes , Thomas Kelder , Daniela Digles , Kristina Hanspers , and Eric Weitz


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Drosophila melanogaster



Pathway Ontology

ketone bodies metabolic pathway


Label Type Compact URI Comment
CG10932 GeneProduct ncbigene:31695
HMGCS2 GeneProduct ncbigene:
CG10399 GeneProduct ncbigene:33978
CG1140 GeneProduct ncbigene:38261
BDH GeneProduct ncbigene:


  1. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Fukao T, Lopaschuk GD, Mitchell GA. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia