Exercise-induced circadian regulation (WP3230)
Bos taurus
Human genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianly regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianly regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianly regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.
Authors
Martina Summer-Kutmon , Kristina Hanspers , and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| MYF6 | GeneProduct | ensembl:ENSBTAG00000014003 | 102265 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4618 |
| KLF9 | GeneProduct | ensembl:ENSBTAG00000016229 | 93527 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:687 |
| HERPUD1 | GeneProduct | ensembl:ENSBTAG00000016896 | 95057 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9709 |
| SF3A3 | GeneProduct | ensembl:ENSBTAG00000007299 | 96029 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10946 |
| CBX3 | GeneProduct | ensembl:ENSBTAG00000005540 | 100405 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11335 |
| AZIN1 | GeneProduct | ensembl:ENSBTAG00000007943 | 101002 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51582 |
| PSMA4 | GeneProduct | ensembl:ENSBTAG00000014440 | 97459 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5685 |
| ZFR | GeneProduct | ensembl:ENSBTAG00000008414 | 104050 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51663 |
| SUMO1 | GeneProduct | ensembl:ENSBTAG00000009859 | 101091 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7341 |
| H2B | GeneProduct | ensembl:ENSBTAG00000031886 | 93833 s atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8341 |
| PURA | GeneProduct | ensembl:ENSBTAG00000008881 | 103501 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5813 |
| CRY2 | GeneProduct | ensembl:ENSBTAG00000021223 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1408 |
| PER1 | GeneProduct | ensembl:ENSBTAG00000003889 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5187 |
| PER2 | GeneProduct | ensembl:ENSBTAG00000045685 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8864 |
| CRY1 | GeneProduct | ensembl:ENSBTAG00000010149 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1407 |
| PPP1R3C | GeneProduct | ensembl:ENSBTAG00000014831 | 93933 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5507 |
| PPP2CB | GeneProduct | ensembl:ENSBTAG00000009245 | 101101 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5516 |
| NCOA4 | GeneProduct | ensembl:ENSBTAG00000019565 | 97843 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8031 |
| ETV6 | GeneProduct | ensembl:ENSBTAG00000014605 | 93866 s atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2120 |
| ERC2 | GeneProduct | ensembl:ENSBTAG00000010029 | 93829 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26059 |
| BOLA-DMA | GeneProduct | ensembl:ENSBTAG00000015730 | 162346 f atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3108 |
| HSPA8 | GeneProduct | ensembl:ENSBTAG00000013162 | 96564 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3312 |
| DNAJA1 | GeneProduct | ensembl:ENSBTAG00000016265 | 97261 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3301 |
| UCP3 | GeneProduct | ensembl:ENSBTAG00000005259 | 93392 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7352 |
| GSTM3 | GeneProduct | ensembl:ENSBTAG00000001842 | 97681 f atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2947 |
| UGP2 | GeneProduct | ensembl:ENSBTAG00000000111 | 94481 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7360 |
| CLDN5 | GeneProduct | ensembl:ENSBTAG00000022020 | 104516 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7122 |
| PIGF | GeneProduct | ensembl:ENSBTAG00000015719 | 104725 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5281 |
| TUBB3 | GeneProduct | ensembl:ENSBTAG00000023730 | 94835 f atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10381 |
| GFRA1 | GeneProduct | ensembl:ENSBTAG00000019297 | 93872 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2674 |
| TAB2 | GeneProduct | ensembl:ENSBTAG00000013454 | 160309 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23118 |
| SUMO3 | GeneProduct | ensembl:ENSBTAG00000017321 | 95424 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6612 |
| GSTP1 | GeneProduct | ensembl:ENSBTAG00000003548 | 99583 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2950 |
| NCKAP1 | GeneProduct | ensembl:ENSBTAG00000033662 | 95508 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10787 |
| VAPA | GeneProduct | ensembl:ENSBTAG00000017279 | 94889 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9218 |
| FAM47E-STBD1 | GeneProduct | ensembl:ENSBTAG00000010389 | 104116 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8987 |
| DAZAP2 | GeneProduct | ensembl:ENSBTAG00000004349 | 94454 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9802 |
| IDI1 | GeneProduct | ensembl:ENSBTAG00000004075 | 96269 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3422 |
| TOB1 | GeneProduct | ensembl:ENSBTAG00000000546 | 99532 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10140 |
| RBPMS | GeneProduct | ensembl:ENSBTAG00000033727 | 103888 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11030 |
| G0S2 | GeneProduct | ensembl:ENSBTAG00000047766 | 97531 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50486 |
| ARNTL | GeneProduct | ensembl:ENSBTAG00000013029 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406 |
| NR1D2 | GeneProduct | ensembl:ENSBTAG00000018024 | 99076 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9975 |
| CLOCK | GeneProduct | ensembl:ENSBTAG00000044044 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9575 |
| BTG1 | GeneProduct | ensembl:ENSBTAG00000020330 | 93104 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:694 |
| EIF4G2 | GeneProduct | ensembl:ENSBTAG00000020308 | 100535 atHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1982 |
| QKI | GeneProduct | ensembl:ENSBTAG00000011593 | 95096 at (mouse)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9444 |
References
- Extensive and divergent circadian gene expression in liver and heart. Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, et al. Nature. 2002 May 2;417(6884):78–83. PubMed Europe PMC Scholia
- Coordinated transcription of key pathways in the mouse by the circadian clock. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, et al. Cell. 2002 May 3;109(3):307–20. PubMed Europe PMC Scholia