GPCRs, other (WP117)

Homo sapiens

This pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Nathan Salomonis , Bruce Conklin , Kristina Hanspers , Alex Pico , Egon Willighagen , Zahra Roudbari , Martina Summer-Kutmon , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
GPR84 GeneProduct ncbigene:53831
RLN3R1 GeneProduct ncbigene:51289
TAAR3 GeneProduct ncbigene:9288
TAAR2 GeneProduct ncbigene:9287
GPR77 GeneProduct ncbigene:27202
GPR55 GeneProduct ncbigene:9290
GPR145 GeneProduct ncbigene:84539
GPR88 GeneProduct ncbigene:54112
GPR62 GeneProduct ncbigene:118442
GPR135 GeneProduct ncbigene:64582
GPR GeneProduct ncbigene:11245
TAAR5 GeneProduct ncbigene:9038
VN1R1 GeneProduct ncbigene:57191
HRH4 GeneProduct ncbigene:59340
CCR5 GeneProduct ncbigene:1234
OR7E24 GeneProduct ncbigene:26648
CELSR3 GeneProduct ncbigene:1951
GNRHR GeneProduct ncbigene:2798
P47889 GeneProduct uniprot:P47889
OR8G2 GeneProduct ncbigene:26492
OR8G1 GeneProduct ncbigene:26494
FSHR GeneProduct ncbigene:2492
F2R GeneProduct ncbigene:2149
ADORA2A GeneProduct ncbigene:135
EDG1 GeneProduct ncbigene:1901
OR10A5 GeneProduct ncbigene:144124
NTSR1 GeneProduct ncbigene:4923
LGR6 GeneProduct ncbigene:59352
HSA8 GeneProduct uniprot:Q9NZP0
HSA3 GeneProduct uniprot:Q9NZP2
HSA12 GeneProduct uniprot:Q9NZP3
HSA10 GeneProduct uniprot:Q9NZP4
HSA1 GeneProduct uniprot:Q9NZP5
HTR1F GeneProduct ncbigene:3355
HTR2A GeneProduct ncbigene:3356
IL8RB GeneProduct ncbigene:3579
IL8RA GeneProduct ncbigene:3577
Q9UEB1 GeneProduct ensembl:ENSG00000185385
OR10A2 GeneProduct ncbigene:341276
UTS2R GeneProduct ncbigene:2837
GPR143 GeneProduct ncbigene:4935
LTB4R2 GeneProduct ncbigene:56413
GPR61 GeneProduct ncbigene:83873
GPR56 GeneProduct ncbigene:9289
GPR116 GeneProduct ncbigene:221395
P2RY13 GeneProduct ncbigene:53829
GPR132 GeneProduct ncbigene:29933
GPR73L1 GeneProduct ncbigene:128674
GPR133 GeneProduct ncbigene:283383
GPR18 GeneProduct ncbigene:2841
OR10A1 GeneProduct ncbigene:144124
CCR2 GeneProduct ncbigene:1231
ADRA1D GeneProduct ncbigene:146
ADORA3 GeneProduct ncbigene:140
ADRB2 GeneProduct ncbigene:154
OR7E18P GeneProduct ncbigene:390885
OR7E19P GeneProduct ncbigene:26651
OR7E35P GeneProduct ncbigene:391632
HTR7 GeneProduct ncbigene:3363
LGR7 GeneProduct ncbigene:59350
OR2M4 GeneProduct ncbigene:26245
OR5-85 GeneProduct uniprot:P30953
OR5D3P GeneProduct ncbigene:8594
OR5E1P GeneProduct ensembl:ENSG00000170688
OR3A4 GeneProduct ensembl:ENSG00000180068
OR2A20P GeneProduct ncbigene:401428
OR2B6 GeneProduct ncbigene:26212
OR1F1 GeneProduct ncbigene:4992
OR2A9P GeneProduct ensembl:ENSG00000228960
OR1N1 GeneProduct ncbigene:138883
OR1E1 GeneProduct ncbigene:8387
OR1G1 GeneProduct ncbigene:8390
OR1E3P GeneProduct ncbigene:8389
OR1R1P GeneProduct ncbigene:9596
OR2F1 GeneProduct ncbigene:26211
OR3A1 GeneProduct ncbigene:4994
OR2H1 GeneProduct ncbigene:26716
OR2A5 GeneProduct ncbigene:393046
OR5D3 GeneProduct uniprot:O95220
OR3A3 GeneProduct ncbigene:8392
GPR17 GeneProduct ncbigene:2840
CELSR2 GeneProduct ncbigene:1952
CELSR1 GeneProduct ncbigene:9620
O60411 GeneProduct uniprot:O60411
OR51A1P GeneProduct ncbigene:26537
GRM8 GeneProduct ncbigene:2918
OR2A4 GeneProduct ncbigene:79541
Q9BYT4 GeneProduct uniprot:Q9BYT4
Q9H2C7 GeneProduct uniprot:Q9H2C7
GRPR GeneProduct ncbigene:2925
OR1J5 GeneProduct ncbigene:81370
CNR1 GeneProduct ncbigene:1268
CHRM3 GeneProduct ncbigene:1131
CHRM2 GeneProduct ncbigene:1129
CCKBR GeneProduct ncbigene:887
CXCR3 GeneProduct ncbigene:2833
GHRHR GeneProduct ncbigene:2692
GRCA GeneProduct ncbigene:27239
GPR83 GeneProduct ncbigene:10888
GRM1 GeneProduct ncbigene:2911
DRD3 GeneProduct ncbigene:1814
DRD4 GeneProduct ncbigene:1815
EMR2 GeneProduct ncbigene:30817
EBI2 GeneProduct ncbigene:1880
EDNRA GeneProduct ncbigene:1909
EMR3 GeneProduct ncbigene:84658
FY GeneProduct ncbigene:2532
ALG6 GeneProduct ncbigene:29929
P2RY11 GeneProduct ncbigene:5032
MASS1 GeneProduct ncbigene:84059
LPHN3 GeneProduct ncbigene:23284
LPHN2 GeneProduct ncbigene:23266
PTGFR GeneProduct ncbigene:5737
SSTR2 GeneProduct ncbigene:6752
SMO GeneProduct ncbigene:6608


  1. GPCRDB: an information system for G protein-coupled receptors. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Classifying G-protein coupled receptors with support vector machines. Karchin R, Karplus K, Haussler D. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia