Osteoblast signaling (WP227)

Rattus norvegicus

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Osteoblasts are specialized, terminally differentiated uninucleated cells responsible for bone formation. Their activity is tightly regulated by external stimuli, originating from e.g. the parathyroid glands, osteocytes, etc. Along with osteoclasts, which are responsible for bone degradation, osteoblasts are key regulators of the shape and volume of bone tissue.

Authors

Ed Hsiao , Alex Pico , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz

Activity

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Organisms

Rattus norvegicus

Communities

Annotations

Cell Type Ontology

osteoblast

Pathway Ontology

signaling pathway pertinent to development

Participants

Label Type Compact Identifier Comment
Parathyroid hormone GeneProduct ncbigene:24694
Osteoprotegerin GeneProduct ncbigene:25341
RANK ligand GeneProduct ncbigene:117516
Bone sialoprotein GeneProduct ncbigene:25295
Bone sialoprotein GeneProduct ncbigene:25295
PTH receptor GeneProduct ncbigene:56813
PDGF Ra GeneProduct ncbigene:25267
FGF-23 GeneProduct ncbigene:170583
Collagen 1 GeneProduct ncbigene:29393
FGF-23 GeneProduct ncbigene:170583
PTH receptor GeneProduct ncbigene:56813
Parathyroid hormone GeneProduct ncbigene:24694
NPT3 GeneProduct ncbigene:25548
Osteoprotegerin GeneProduct ncbigene:25341
Osteocalcin GeneProduct ncbigene:25295
PDGF Rb GeneProduct ncbigene:24629
PDGF Ra GeneProduct ncbigene:25267
PDGF Rb GeneProduct ncbigene:24629

References