Pentose phosphate metabolism (WP134)

Homo sapiens

Pentose phosphate, phosphogluconate, or hexose monophsphate pathway oxidizes glucose-6-phosphate to fructose-6-phosphate and glyceraldehyde-3-P. NADP+ is the electron acceptor. The pathways yields NADPH as well as 5, 4, and 7 carbon intermediaries for synthesis of nucleotides. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP134 CPTAC Assay Portal]

Authors

Kdahlquist , Martijn Van Iersel , Kristina Hanspers , Adrien Defay , Alex Pico , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , Friederike Ehrhart , Eric Weitz , and Marvin Martens

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

pentose phosphate pathway

Participants

Label Type Compact URI Comment
Sedoheptulose-7-Phosphate Metabolite cas:2646-35-7
Fructose-6-Phosphate Metabolite cas:643-13-0
Xylulose-5-Phosphate Metabolite cas:60802-29-1
Glyceraldehyde-3-phosphate Metabolite hmdb:HMDB0001112
D-Ribose-5-Phosphate Metabolite cas:3615-55-2
6-Phosphogluconate Metabolite hmdb:HMDB0001316
Erythrose-4-Phosphate Metabolite hmdb:HMDB0001321
Ribulose-5-Phosphate Metabolite cas:4151-19-3
Glucose-6-Phosphate Metabolite cas:56-73-5
6-Phosphonoglucono-delta-lactone Metabolite hmdb:HMDB0001127
Fructose-6-Phosphate Metabolite hmdb:HMDB0000124
G6PD GeneProduct ncbigene:2539
PGLS GeneProduct ncbigene:25796
RPE GeneProduct ncbigene:6120
TALDO1 GeneProduct ncbigene:6888
RPIA GeneProduct ncbigene:22934
TKT GeneProduct ncbigene:7086
PGD GeneProduct ncbigene:5226

References

  1. Biochemistry. Howland J. Biochemical Education [Internet]. 1990 Oct;18(4):212. Available from: http://dx.doi.org/10.1016/0307-4412(90)90145-E DOI Scholia