Pentose phosphate metabolism (WP134)

Homo sapiens

Pentose phosphate, phosphogluconate, or hexose monophsphate pathway oxidizes glucose-6-phosphate to fructose-6-phosphate and glyceraldehyde-3-P. NADP+ is the electron acceptor. The pathways yields NADPH as well as 5, 4, and 7 carbon intermediaries for synthesis of nucleotides. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Kdahlquist , Martijn Van Iersel , Kristina Hanspers , Adrien Defay , Alex Pico , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , Friederike Ehrhart , Eric Weitz , and Marvin Martens


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

pentose phosphate pathway


Label Type Compact URI Comment
Sedoheptulose-7-Phosphate Metabolite cas:2646-35-7
Fructose-6-Phosphate Metabolite cas:643-13-0
Xylulose-5-Phosphate Metabolite cas:60802-29-1
Glyceraldehyde-3-phosphate Metabolite hmdb:HMDB0001112
D-Ribose-5-Phosphate Metabolite cas:3615-55-2
6-Phosphogluconate Metabolite hmdb:HMDB0001316
Erythrose-4-Phosphate Metabolite hmdb:HMDB0001321
Ribulose-5-Phosphate Metabolite cas:4151-19-3
Glucose-6-Phosphate Metabolite cas:56-73-5
Glyceraldehyde-3-phosphate Metabolite hmdb:HMDB0001112
6-Phosphonoglucono-delta-lactone Metabolite hmdb:HMDB0001127
Fructose-6-Phosphate Metabolite hmdb:HMDB0000124
G6PD GeneProduct ncbigene:2539
PGLS GeneProduct ncbigene:25796
RPE GeneProduct ncbigene:6120
TALDO1 GeneProduct ncbigene:6888
RPIA GeneProduct ncbigene:22934
TKT GeneProduct ncbigene:7086
PGD GeneProduct ncbigene:5226
TKT GeneProduct ncbigene:7086


  1. Biochemistry [Internet]. Voet D, Voet JG. 1990. 1276 p. Available from: OpenLibrary Worldcat