Renin-angiotensin-aldosterone system (RAAS) (WP4756)

Homo sapiens

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The pathway leading angiotensinogen to aldosterone

Authors

Ozan Ozisik , Marvin Martens , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

ACE inhibitor drug pathway renin-angiotensin cascade pathway aldosterone biosynthetic pathway angiotensin signaling pathway

Disease Ontology

hypertension

Participants
Query Drugst.One

Label Type Compact URI Comment
18-hydroxycorticosterone Metabolite chebi:16485
IP3 Metabolite chebi:16595
Corticosterone Metabolite chebi:16827
11-Deoxycorticosterone Metabolite chebi:16973
Progesterone Metabolite chebi:17026
Cholesterol Metabolite chebi:16113
Angiotensin II Metabolite hmdb:HMDB0001035
Angiotensin I Metabolite pubchem.compound:3081372
ACE Inhibitor Metabolite chebi:35457
Pregnenolone Metabolite chebi:16581
calcium Metabolite chebi:29108
Aldosterone Metabolite hmdb:HMDB0000037
CYP11A1 GeneProduct hgnc.symbol:CYP11A1
HSD3B2 GeneProduct hgnc.symbol:HSD3B2
CALML5 GeneProduct hgnc.symbol:CALML5
CAMK1D GeneProduct hgnc.symbol:CAMK1D
CYP21A2 GeneProduct hgnc.symbol:CYP21A2
CYP11B2 GeneProduct hgnc.symbol:CYP11B2
CALM1 GeneProduct hgnc.symbol:CALM1
CALML6 GeneProduct hgnc.symbol:CALML6
ITPR1 GeneProduct hgnc.symbol:ITPR1
CALML3 GeneProduct hgnc.symbol:CALML3
CTSG GeneProduct ncbigene:1511
CALML4 GeneProduct hgnc.symbol:CALML4
ITPR2 GeneProduct hgnc.symbol:ITPR2
HSD3B1 GeneProduct hgnc.symbol:HSD3B1
ITPR3 GeneProduct hgnc.symbol:ITPR3
CALM2 GeneProduct hgnc.symbol:CALM2
PLCB2 GeneProduct hgnc.symbol:PLCB2
CMA1 GeneProduct ncbigene:1215
REN GeneProduct ncbigene:5972
ATF6B GeneProduct hgnc.symbol:ATF6B
AGT GeneProduct ncbigene:183
ACE GeneProduct ncbigene:1636
CALM3 GeneProduct hgnc.symbol:CALM3
GNAQ GeneProduct hgnc.symbol:GNAQ
AGTR2 GeneProduct ncbigene:186
AGTR1 GeneProduct ncbigene:185
CAMK1G GeneProduct hgnc.symbol:CAMK1G
CAMK4 GeneProduct hgnc.symbol:CAMK4
CAMK2A GeneProduct hgnc.symbol:CAMK2A
CAMK2B GeneProduct hgnc.symbol:CAMK2B
CAMK2D GeneProduct hgnc.symbol:CAMK2D
CAMK2G GeneProduct hgnc.symbol:CAMK2G
CAMK1 GeneProduct hgnc.symbol:CAMK1
ATF2 GeneProduct hgnc.symbol:ATF2
ATF1 GeneProduct hgnc.symbol:ATF1
CREB5 GeneProduct hgnc.symbol:CREB5
CREB3L4 GeneProduct hgnc.symbol:CREB3L4
CREB3L3 GeneProduct hgnc.symbol:CREB3L3
CREB3L2 GeneProduct hgnc.symbol:CREB3L2
CREB3L1 GeneProduct hgnc.symbol:CREB3L1
CREB3 GeneProduct hgnc.symbol:CREB3
CREB1 GeneProduct hgnc.symbol:CREB1
ATF4 GeneProduct hgnc.symbol:ATF4
STAR Protein hgnc.symbol:STAR

References

  1. The regulation of aldosterone synthase expression. Bassett MH, White PC, Rainey WE. Mol Cell Endocrinol. 2004 Mar 31;217(1–2):67–74. PubMed Europe PMC Scholia
  2. Pharmacogenetics of antihypertensive drug responses. Schwartz GL, Turner ST. Am J Pharmacogenomics. 2004;4(3):151–60. PubMed Europe PMC Scholia
  3. Aldosterone biosynthesis, regulation, and classical mechanism of action. Williams GH. Heart Fail Rev. 2005 Jan;10(1):7–13. PubMed Europe PMC Scholia
  4. Effects of renin-angiotensin system inhibition on end-organ protection: can we do better? Weir MR. Clin Ther. 2007 Sep;29(9):1803–24. PubMed Europe PMC Scholia