Nuclear receptors (WP1184)

Canis familiaris

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia ([[wikipedia:Nuclear_receptor]])


Alex Pico , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz


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Canis familiaris



Pathway Ontology

transcription factor mediated signaling pathway


Label Type Compact URI Comment
THRA GeneProduct ncbigene:403601
THRB GeneProduct ncbigene:403599
THRB GeneProduct ncbigene:403599
RARA GeneProduct ncbigene:480526
RARB GeneProduct ncbigene:477045
RARG GeneProduct ncbigene:486508
RARG GeneProduct ncbigene:486508
PPARA GeneProduct ncbigene:403654
PPARD GeneProduct ncbigene:481756
PPARG GeneProduct ncbigene:403606
PPARG GeneProduct ncbigene:403606
NR1D2 GeneProduct ncbigene:485643
NR0B1 GeneProduct ncbigene:491804
ROR1 GeneProduct ncbigene:489557
RORA GeneProduct ncbigene:478328
RORC GeneProduct ncbigene:483205
NR1H2 GeneProduct ncbigene:610057
NR1H3 GeneProduct ncbigene:483625
VDR GeneProduct ncbigene:486588
HNF4A GeneProduct ncbigene:485884
RXRA GeneProduct ncbigene:491278
RXRB GeneProduct ncbigene:481735
RXRG GeneProduct ncbigene:478989
NR2C2 GeneProduct ncbigene:484641
NR2F1 GeneProduct ncbigene:488908
NR2F2 GeneProduct ncbigene:479026
NR2F6 GeneProduct ncbigene:609720
NR2E1 GeneProduct ncbigene:475017
ESR1 GeneProduct ncbigene:403640
ESR2 GeneProduct ncbigene:403639
ESRRA GeneProduct ncbigene:403169
ESRRB GeneProduct ncbigene:490798
NR3C1 GeneProduct ncbigene:478047
PGR GeneProduct ncbigene:403621
AR GeneProduct ncbigene:403588
NR4A1 GeneProduct ncbigene:403897
NR4A2 GeneProduct ncbigene:478754
NR5A1 GeneProduct ncbigene:609642
NR5A2 GeneProduct ncbigene:490252
NR1I2 GeneProduct ncbigene:403482
NR1I3 GeneProduct ncbigene:488653


  1. Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease. Nagy L, Schüle R, Gronemeyer H. EMBO Rep. 2006 Jun;7(6):579–84. PubMed Europe PMC Scholia