PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (WP3844)
This pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resistant prostate cancer. The signaling pathway regulates many cellular processes such as protein synthesis, proliferation, survival, metabolism, and differentiation, all factors that would increase a cancerous cell's ability to survive. Scientists have explored the use of various inhibitors for different parts of the signaling pathway, and have been faced with varying success. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3844 CPTAC Assay Portal]
AuthorsAAR&Co , Friederike Ehrhart , Alex Pico , Kristina Hanspers , Martina Summer-Kutmon , Liling , and Denise Slenter
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- Machine learning and bioinformatics to identify 8 autophagy-related biomarkers and construct gene regulatory networks in dilated cardiomyopathy (2022).
- Identification of candidate genes and pathways in retinopathy of prematurity by whole exome sequencing of preterm infants enriched in phenotypic extremes (2021).
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Pathway Ontologyphosphatidylinositol 3-kinase-Akt signaling pathway phosphatidylinositol 3-kinase signaling pathway signaling pathway
- PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance. Edlind MP, Hsieh AC. Asian J Androl. 2014;16(3):378–86. PubMed Europe PMC Scholia