ATR signaling (WP3875)

Homo sapiens

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This pathway is modeled after Figure 1 in the article “ ATR signalling: more than meeting at the fork” (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Authors

AAR&Co , Kristina Hanspers , Martina Summer-Kutmon , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC ONTOX

Annotations

Pathway Ontology

DNA damage response pathway DNA replication pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ATRIP GeneProduct ensembl:ENSG00000164053
RAD9B GeneProduct ensembl:ENSG00000151164
RAD1 GeneProduct ensembl:ENSG00000113456
CHEK1 GeneProduct ensembl:ENSG00000149554
RAD9A GeneProduct ensembl:ENSG00000172613
HUS1 GeneProduct ensembl:ENSG00000136273
ATR GeneProduct ensembl:ENSG00000175054
RPA2 GeneProduct hgnc.symbol:RPA2
RPA3 GeneProduct hgnc.symbol:RPA3
RPA1 GeneProduct hgnc.symbol:RPA1
TOPBP1 GeneProduct ensembl:ENSG00000163781

References

  1. ATR signalling: more than meeting at the fork. Nam EA, Cortez D. Biochem J. 2011 Jun 15;436(3):527–36. PubMed Europe PMC Scholia