ATR signaling (WP3875)
This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3875 CPTAC Assay Portal]
AuthorsAAR&Co , Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz
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Pathway OntologyDNA replication pathway DNA damage response pathway
- ATR signalling: more than meeting at the fork. Nam EA, Cortez D. Biochem J. 2011 Jun 15;436(3):527–36. PubMed Europe PMC Scholia