ATR signaling (WP3875)

Homo sapiens

This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3875 CPTAC Assay Portal]

Authors

AAR&Co , Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited By

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

DNA replication pathway DNA damage response pathway

Participants

Label Type Compact Identifier Comment
RAD9B GeneProduct ensembl:ENSG00000151164
RAD1 GeneProduct ensembl:ENSG00000113456
CHK1 GeneProduct ensembl:ENSG00000149554
RAD9A GeneProduct ensembl:ENSG00000172613
HUS1 GeneProduct ensembl:ENSG00000136273
RPA GeneProduct ensembl:ENSG00000132383
ATR GeneProduct ensembl:ENSG00000175054
ATRIP GeneProduct ensembl:ENSG00000164053
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
ATR GeneProduct ensembl:ENSG00000175054
ATRIP GeneProduct ensembl:ENSG00000164053
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
RPA GeneProduct ensembl:ENSG00000132383
ATR GeneProduct ensembl:ENSG00000175054
ATRIP GeneProduct ensembl:ENSG00000164053
TOPBP1 GeneProduct ensembl:ENSG00000163781
HUS1 GeneProduct ensembl:ENSG00000136273
RAD9B GeneProduct ensembl:ENSG00000151164
RAD9A GeneProduct ensembl:ENSG00000172613
RAD1 GeneProduct ensembl:ENSG00000113456

References

  1. ATR signalling: more than meeting at the fork. Nam EA, Cortez D. Biochem J. 2011 Jun 15;436(3):527–36. PubMed Europe PMC Scholia