Alzheimer's disease (WP2075)

Mus musculus

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. See below source URL for more information.


Kristina Hanspers , Egon Willighagen , Lovnish Thakur , Friederike Ehrhart , Lauren J. Dupuis , Laurent Winckers , and Eric Weitz


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Mus musculus



Disease Ontology

Alzheimer's disease

Pathway Ontology

disease pathway Alzheimer's disease pathway


Label Type Compact URI Comment
NO Metabolite hmdb:HMDB0003378
Iron Metabolite hmdb:HMDB0000692
Hydrogen peroxide Metabolite hmdb:HMDB0003125
IP3 Metabolite hmdb:HMDB0001498
Copper Metabolite hmdb:HMDB0000657
Calcium Metabolite hmdb:HMDB0000464
Calcium Metabolite hmdb:HMDB0000464
Calcium Metabolite hmdb:HMDB0000464
ONOO- Metabolite hmdb:HMDB0002179
Nae1 GeneProduct ensembl:ENSMUSG00000031878
App GeneProduct ensembl:ENSMUSG00000022892
Apbb1 GeneProduct ensembl:ENSMUSG00000037032
Gm2221 GeneProduct ensembl:ENSMUSG00000090825
Adam10 GeneProduct ensembl:ENSMUSG00000054693
Bace1 GeneProduct ensembl:ENSMUSG00000032086
Psenen GeneProduct ensembl:ENSMUSG00000036835
Psen1 GeneProduct ensembl:ENSMUSG00000019969
Ncstn GeneProduct ensembl:ENSMUSG00000003458
Aph1a GeneProduct ensembl:ENSMUSG00000015750
Ide GeneProduct ensembl:ENSMUSG00000056999
Mme GeneProduct ensembl:ENSMUSG00000027820
Lpl GeneProduct ensembl:ENSMUSG00000015568
Apoe GeneProduct ensembl:ENSMUSG00000002985
Lrp1 GeneProduct ensembl:ENSMUSG00000040249
Fas GeneProduct ensembl:ENSMUSG00000024778
Tnfrsf1a GeneProduct ensembl:ENSMUSG00000030341
Fadd GeneProduct ensembl:ENSMUSG00000031077
Casp8 GeneProduct ensembl:ENSMUSG00000026029
Hsd17b10 GeneProduct ensembl:ENSMUSG00000025260
Bid GeneProduct ensembl:ENSMUSG00000004446
Gm10121 GeneProduct ensembl:ENSMUSG00000062813
Calm2 GeneProduct ensembl:ENSMUSG00000036438
1500003O03Rik GeneProduct ncbigene:56398
Bad GeneProduct ensembl:ENSMUSG00000024959
Calml3 GeneProduct ensembl:ENSMUSG00000063130
Calm4 GeneProduct ensembl:ENSMUSG00000033765
Ppp3ca GeneProduct ensembl:ENSMUSG00000028161
Ppp3cb GeneProduct ensembl:ENSMUSG00000021816
Ppp3cc GeneProduct ensembl:ENSMUSG00000022092
Ppp3r1 GeneProduct ensembl:ENSMUSG00000033953
Ppp3r2 GeneProduct ensembl:ENSMUSG00000028310
2010110P09Rik GeneProduct ncbigene:70261
Adam17 GeneProduct ensembl:ENSMUSG00000052593
Psen2 GeneProduct ensembl:ENSMUSG00000010609
Apaf1 GeneProduct ensembl:ENSMUSG00000019979
Casp9 GeneProduct ensembl:ENSMUSG00000028914
Casp3 GeneProduct ensembl:ENSMUSG00000031628
Snca GeneProduct ensembl:ENSMUSG00000025889
Grin1 GeneProduct ensembl:ENSMUSG00000026959
Cacna1c GeneProduct ensembl:ENSMUSG00000051331
Grin2a GeneProduct ensembl:ENSMUSG00000059003
Grin2b GeneProduct ensembl:ENSMUSG00000030209
Grin2c GeneProduct ensembl:ENSMUSG00000020734
Grin2d GeneProduct ensembl:ENSMUSG00000002771
Cacna1d GeneProduct ensembl:ENSMUSG00000015968
Cacna1f GeneProduct ensembl:ENSMUSG00000031142
Cacna1s GeneProduct ensembl:ENSMUSG00000026407
Gnaq GeneProduct ensembl:ENSMUSG00000024639
Plcb1 GeneProduct ensembl:ENSMUSG00000051177
Plcb2 GeneProduct ensembl:ENSMUSG00000040061
Plcb3 GeneProduct ensembl:ENSMUSG00000024960
Plcb4 GeneProduct ensembl:ENSMUSG00000039943
Tnf GeneProduct ensembl:ENSMUSG00000024401
Il1b GeneProduct ensembl:ENSMUSG00000027398
Mapk1 GeneProduct ensembl:ENSMUSG00000063358
Mapk3 GeneProduct ensembl:ENSMUSG00000063065
Casp12 GeneProduct ensembl:ENSMUSG00000025887
Ryr3 GeneProduct ensembl:ENSMUSG00000057378
Psenen GeneProduct ensembl:ENSMUSG00000036835
Atp2a2 GeneProduct ensembl:ENSMUSG00000029467
Atp2a1 GeneProduct ensembl:ENSMUSG00000030730
Atp2a3 GeneProduct ensembl:ENSMUSG00000020788
Eif2ak3 GeneProduct ensembl:ENSMUSG00000031668
Ern1 GeneProduct ensembl:ENSMUSG00000020715
Atf6 GeneProduct ensembl:ENSMUSG00000026663
Itpr1 GeneProduct ensembl:ENSMUSG00000030102
Itpr2 GeneProduct ensembl:ENSMUSG00000030287
Itpr3 GeneProduct ensembl:ENSMUSG00000042644
Capn1 GeneProduct ensembl:ENSMUSG00000024942
Capn2 GeneProduct ensembl:ENSMUSG00000026509
Trp53 GeneProduct ensembl:ENSMUSG00000059552
Cdk5r1 GeneProduct ensembl:ENSMUSG00000048895
Nos1 GeneProduct ensembl:ENSMUSG00000029361
Cdk5 GeneProduct ensembl:ENSMUSG00000028969
Tau GeneProduct ensembl:ENSMUSG00000018411
Gsk3b GeneProduct ensembl:ENSMUSG00000022812
Casp3 GeneProduct ensembl:ENSMUSG00000031628
Casp7 GeneProduct ensembl:ENSMUSG00000025076


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