ACE inhibitor pathway (WP557)

Rattus norvegicus

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (


Caroline F. Thorn , Kristina Hanspers , Thomas Kelder , Egon Willighagen , Christine Chichester , and Eric Weitz


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Rattus norvegicus



Pathway Ontology

ACE inhibitor drug pathway


Label Type Compact URI Comment
Bradykinin Metabolite hmdb:HMDB0004246
Angiotensin I Metabolite pubchem.compound:3081372
Aldosterone Metabolite chebi:27584
ACE Inhibitor Metabolite chebi:35457
Angiotensin II Metabolite hmdb:HMDB0001035
Ace GeneProduct ncbigene:24310
Nos3 GeneProduct ncbigene:24600
Kng1 GeneProduct ncbigene:24903
Agt GeneProduct ncbigene:24179
Agtr1 GeneProduct ncbigene:81638
Agtr2 GeneProduct ncbigene:24182
Ren1 GeneProduct ncbigene:24715
Ace GeneProduct ncbigene:24310
Bdkrb2 GeneProduct ncbigene:25245


  1. The emerging role of ACE2 in physiology and disease. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus ADME, et al. J Pathol. 2007 May;212(1):1–11. PubMed Europe PMC Scholia