Cholesterol metabolism with Bloch and Kandutsch-Russell pathways (WP4718)

Homo sapiens

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New PW, homology converted

Authors

Denise Slenter , Eric Weitz , and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Lipids and LIPID MAPS

Annotations

Pathway Ontology

cholesterol biosynthetic pathway cholesterol metabolic pathway lipid signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
9Z-palmitoleic acid Metabolite pubchem.compound:445638 Assuming this is omega 7-type
7alpha-hydroxycholesterol Metabolite lipidmaps:LMST01010013
Acetyl-CoA Metabolite lipidmaps:LMFA07050281
CE(16:1) Metabolite wikidata:Q412366 Assuming this is omega-7 type
Acetoacetyl-CoA Metabolite lipidmaps:LMFA07050030
HMG-CoA Metabolite lipidmaps:LMFA07050116
Mevalonic acid Metabolite lipidmaps:LMFA01050352
Mevalonate-5-P Metabolite lipidmaps:LMFA01050415
Mevalonate-5-PP Metabolite lipidmaps:LMFA01050416
Isopentenyl-PP Metabolite lipidmaps:LMPR01010008
Dimethylallyl-PP Metabolite lipidmaps:LMPR01010001
Geranyl-PP Metabolite lipidmaps:LMPR0102010001
Farnesyl-PP Metabolite lipidmaps:LMPR0103010002
Squalene Metabolite lipidmaps:LMPR0106010002
Squalene-2,3-epoxide Metabolite lipidmaps:LMPR0106010010
Diepoxy-squalene Metabolite lipidmaps:LMPR0106010038
Lanosterol Metabolite lipidmaps:LMST01010017
24,25-epoxycholesterol Metabolite lipidmaps:LMST01010012
24,25-dihydrolanosterol Metabolite lipidmaps:LMST01010087
32-hydroxylanosterol Metabolite lipidmaps:LMST01010124
4,4-dimethylcholesta-5,8,24-trienol Metabolite lipidmaps:LMST01010149
4,4-dimethylcholest-8-enol Metabolite lipidmaps:LMST01010225
14-demethyl-lanosterol Metabolite lipidmaps:LMST01010176
4-alpha-methylcholest-8-enol Metabolite lipidmaps:LMST01010197
Zymosterol Metabolite lipidmaps:LMST01010066
4-alpha-methyl-cholest-8-enone Metabolite lipidmaps:LMST01010236
Zymostenol Metabolite lipidmaps:LMST01010096
Lathosterol Metabolite lipidmaps:LMST01010089
7-dehdrocholesterol Metabolite lipidmaps:LMST01010069
Cholestadienol Metabolite lipidmaps:LMST01010206 aka 24-dehydrolathosterol
7-dehydodesmosterol Metabolite lipidmaps:LMST01010121
Desmosterol Metabolite lipidmaps:LMST01010016
Cholesterol Metabolite lipidmaps:LMST01010001
7-oxocholesterol Metabolite lipidmaps:LMST01010049
Cholestenone Metabolite lipidmaps:LMST01010015
4beta-hydroxycholesterol Metabolite lipidmaps:LMST01010014
24S-hydroxycholesterol Metabolite lipidmaps:LMST01010019
25-hydroxycholesterol Metabolite lipidmaps:LMST01010018
27-hydroxycholesterol Metabolite lipidmaps:LMST01010057
Cholesteryl esters (CE) Metabolite chebi:17002
Acyl-CoA Metabolite lipidmaps:LMFA07050000
PreSqualene Metabolite wikidata:Q27088444 Annotated while assuming this compound is actually presqualene-diphosphate
CE(18:1) Metabolite wikidata:Q27116670 Assuming this is omega-7 type
Oleic acid Metabolite wikidata:Q207688 Aka C18:1 (omega 9)
4-methyl zymostenol Metabolite pubchem.compound:22212495
FF-MAS Metabolite cas:64284-64-6 aka 14-demethyl-14-dehydrolanosterol
C12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC=[C@@]21C SMILES
SREBF1 GeneProduct ensembl:ENSG00000072310 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020538
ABCA1 GeneProduct ensembl:ENSG00000165029 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015243
CH25H GeneProduct ensembl:ENSG00000138135 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642
HMGCR GeneProduct ensembl:ENSG00000113161 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15357
NR1H3 GeneProduct ensembl:ENSG00000025434 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002108
SOAT1 GeneProduct ensembl:ENSG00000057252 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20652
FASN GeneProduct ensembl:ENSG00000169710 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025153
DHCR7 GeneProduct ensembl:ENSG00000172893 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360
SC5D GeneProduct ensembl:ENSG00000109929 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235293
EBP GeneProduct ensembl:ENSG00000147155 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13595
NSDHL GeneProduct ensembl:ENSG00000147383 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18194
CYP51A1 GeneProduct ensembl:ENSG00000001630 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121
TM7SF2 GeneProduct ensembl:ENSG00000149809 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166
MSMO1 GeneProduct ensembl:ENSG00000052802 aka Sc4mol
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234
HSD17B7 GeneProduct ensembl:ENSG00000132196 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490
DHCR24 GeneProduct ensembl:ENSG00000116133 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754
CYP46A1 GeneProduct ensembl:ENSG00000036530 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13116
CYP27A1 GeneProduct ensembl:ENSG00000135929 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086
SOAT2 GeneProduct ensembl:ENSG00000167780 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223920
ACAT2 GeneProduct ensembl:ENSG00000120437 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210
HMGCS1 GeneProduct ensembl:ENSG00000112972 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208715
HMGCS2 GeneProduct ensembl:ENSG00000134240 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360
MVK GeneProduct ensembl:ENSG00000110921 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17855
PMVK GeneProduct ensembl:ENSG00000163344 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68603
MVD GeneProduct ensembl:ENSG00000167508 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192156
SQLE GeneProduct ensembl:ENSG00000104549 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20775
IDI1 GeneProduct ensembl:ENSG00000067064 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319554
FDFT1 GeneProduct ensembl:ENSG00000079459 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14137
GGPS1 GeneProduct ensembl:ENSG00000152904 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14593
FDPS GeneProduct ensembl:ENSG00000160752 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110196
LSS GeneProduct ensembl:ENSG00000160285 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16987
CYP51A1 GeneProduct ensembl:ENSG00000001630 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121
DHCR7 GeneProduct ensembl:ENSG00000172893 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360
DHCR24 GeneProduct ensembl:ENSG00000116133 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754
NR1H2 GeneProduct ensembl:ENSG00000131408 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000060601
ABCG1 GeneProduct ensembl:ENSG00000160179 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024030
MYLIP GeneProduct ensembl:ENSG00000007944 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038175
SREBF2 GeneProduct ensembl:ENSG00000198911 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022463
ACSL1 GeneProduct ensembl:ENSG00000151726 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018796
ACSL3 GeneProduct ensembl:ENSG00000123983 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032883
ACSL4 GeneProduct ensembl:ENSG00000068366 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031278
ACOT2 GeneProduct ensembl:ENSG00000119673 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021226
DHCR24 Protein ensembl:ENSG00000116133 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8VCH6
ELOVL2 Protein ensembl:ENSG00000197977 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021364
ELOVL3 Protein ensembl:ENSG00000119915 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038754
ELOVL4 Protein ensembl:ENSG00000118402 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032262
ELOVL5 Protein ensembl:ENSG00000012660 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032349
FADS1 Protein ensembl:ENSG00000149485 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000010663
FADS2 Protein ensembl:ENSG00000134824 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024665
SCD Protein ensembl:ENSG00000099194 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037071
CYP51A1 Protein ensembl:ENSG00000001630 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4
TM7SF2 Protein ensembl:ENSG00000149809 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q71KT5
MSMO1 Protein ensembl:ENSG00000052802 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4
NSDHL Protein ensembl:ENSG00000147383 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0
LBR Protein ensembl:ENSG00000143815 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9
TM7SF2 Protein ensembl:ENSG00000149809 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166
MSMO1 Protein ensembl:ENSG00000052802 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4
NSDHL Protein ensembl:ENSG00000147383 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0
LBR Protein ensembl:ENSG00000143815 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9
HSD17B7 Protein ensembl:ENSG00000132196 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490
MSMO1 Protein ensembl:ENSG00000052802 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4
NSDHL Protein ensembl:ENSG00000147383 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0
HSD17B7 Protein ensembl:ENSG00000132196 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490
CYP51A1 Protein ensembl:ENSG00000001630 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4
HSD17B7 Protein ensembl:ENSG00000132196 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490

References

  1. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Bae SH, Paik YK. Biochem J. 1997 Sep 1;326 ( Pt 2)(Pt 2):609–16. PubMed Europe PMC Scholia
  2. A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
  3. Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. Bogan RL, Debarber AE, Hennebold JD. Biol Reprod. 2012 Mar 30;86(3):89. PubMed Europe PMC Scholia
  4. Steroidal triterpenes of cholesterol synthesis. Ačimovič J, Rozman D. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia
  5. Steroidal triterpenes of cholesterol synthesis. Ačimovič J, Rozman D. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia