IL18 signaling (WP4754)
Homo sapiens
Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and was initially described as an IFN-γ-inducing factor derived from anti-CD3-stimulated Th1 cells. IL-18 plays a significant role in the activation of hematopoietic cell types mediating both Th1 and Th2 responses and is the primary inducer of interferon-γ in these cells. The biological activity of IL-18 is mediated through its binding to the IL-18 receptor complex (IL-18R) and activation of nuclear factor-kB (NF-kB), culminating in the production and release of several cytokines, chemokines, and cellular adhesion molecules. In certain cell types, IL-18 also activates mitogen-activated protein kinases (MAPKs) and PI3K/AKT signaling modules leading to the production and release of proinflammatory cytokines. IL-18 mediated signaling acts as one of the vital components of the immunomodulatory cytokine networks involved in host defense, inflammation, and tissue regeneration.
Authors
Yashwanth Subbannayya , Kristina Hanspers , Egon Willighagen , Rex D A B , and Eric WeitzActivity
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Cited In
- Machine learning and bioinformatics to identify 8 autophagy-related biomarkers and construct gene regulatory networks in dilated cardiomyopathy (2022).
- The Biological Interaction of SARS-CoV-2 Infection and Osteoporosis: A Preliminary Study (2022).
- Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition (2020).
- A comprehensive pathway map of IL-18-mediated signalling (2019).
- GediNET for discovering gene associations across diseases using knowledge based machine learning approach (2022).
- Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD) (2022).
- Gastric cancer actionable genomic alterations across diverse populations worldwide and pharmacogenomics strategies based on precision oncology (2024).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
oxidative phosphorylation pathway Interleukin mediated signaling pathway signaling pathway in the adaptive immune response interleukin-1 signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
CYCS | GeneProduct | ncbigene:54205 | |
BAX | GeneProduct | ncbigene:581 | |
MAPK1 | GeneProduct | ncbigene:5594 | |
IL-18BP | GeneProduct | ncbiprotein:10068 | |
CASP8 | GeneProduct | ncbigene:841 | |
NOX1 | GeneProduct | ncbigene:27035 | |
TICAM2 | GeneProduct | ncbigene:353376 | |
SLC12A3 | GeneProduct | ncbigene:6559 | |
LCK | GeneProduct | ncbigene:3932 | |
CYCS | GeneProduct | ncbigene:54205 | |
NFKB1 | GeneProduct | ncbigene:4790 | |
NCF1 | GeneProduct | ncbigene:653361 | |
NCF2 | GeneProduct | ncbigene:4688 | |
NCF1 | GeneProduct | ncbigene:653361 | |
NCF2 | GeneProduct | ncbigene:4688 | |
IMP3 | GeneProduct | ncbigene:55272 | |
ELAVL1 | GeneProduct | ncbigene:1994 | |
CTNNB1 | GeneProduct | ncbigene:1499 | |
GSK3B | GeneProduct | ncbigene:2932 | |
Protein | GeneProduct | ncbigene:11 | |
AKT1 | GeneProduct | ncbiprotein:NP_005154.2 | |
MAPK3 | GeneProduct | ncbigene:5595 | |
CREB1 | GeneProduct | ncbiprotein:NP_604391.1 | |
MAPK14 | GeneProduct | ncbiprotein:NP_001306.1 | |
PIK3R1 | GeneProduct | ncbigene:5295 | |
ELK1 | GeneProduct | ncbiprotein:NP_001107595.1 | |
MAPK8 | GeneProduct | ncbiprotein:NP_620637.1 | |
CHUK | GeneProduct | ncbigene:1147 | |
IKBKB | GeneProduct | ncbigene:3551 | |
RPS6 | GeneProduct | ncbiprotein:NP_001001.2 | |
SRC | GeneProduct | ncbiprotein:NP_005408.1 | |
NFKBIA | GeneProduct | ncbigene:4792 | |
HSPB1 | GeneProduct | ncbigene:3315 | |
CSN2 | GeneProduct | ncbigene:1447 | |
MAP3K7 | GeneProduct | ncbigene:6885 | |
GSK3A | GeneProduct | ncbiprotein:NP_002084.2 | |
PTEN | GeneProduct | ncbigene:5728 | |
ACACB | GeneProduct | ncbigene:32 | |
JUN | GeneProduct | ncbiprotein:NP_002219.1 | |
GRIN2B | GeneProduct | ncbigene:2904 | |
PRKCA | GeneProduct | ncbigene:5578 | |
PRKCB | GeneProduct | ncbigene:5579 | |
RAF1 | GeneProduct | ncbiprotein:NP_001341618.1 | |
TNFRSF1A | GeneProduct | ncbigene:7132 | |
MEF2A | GeneProduct | ncbigene:4205 | |
CEBPB | GeneProduct | ncbigene:1051 | |
GATA1 | GeneProduct | ncbigene:2623 | |
SP1 | GeneProduct | ncbigene:6667 | |
CFLAR | GeneProduct | ncbigene:8837 | |
BID | GeneProduct | ncbigene:637 | |
CASP3 | GeneProduct | ncbigene:836 | |
IRF1 | GeneProduct | ncbigene:3659 | |
TNF | GeneProduct | ncbigene:7124 | |
TP53 | GeneProduct | ncbigene:7157 | |
FASLG | GeneProduct | ncbigene:356 | |
FAS | GeneProduct | ncbigene:355 | |
MAPK9 | GeneProduct | ncbigene:5601 | |
Protein | GeneProduct | ncbigene:11 | |
ELAVL1 | GeneProduct | ncbigene:1994 | |
IMP3 | GeneProduct | ncbigene:55272 | |
NFATC4 | GeneProduct | ncbigene:4776 | |
NFKB1 | GeneProduct | ncbigene:4790 | |
RELA | GeneProduct | ncbigene:5970 | |
CTNNB1 | GeneProduct | ncbigene:1499 | |
GSK3B | GeneProduct | ncbigene:2932 | |
NFATC4 | GeneProduct | ncbigene:4776 | |
RELA | GeneProduct | ncbigene:5970 | |
IRAK4 | GeneProduct | ncbigene:12682231 | |
MAP2K7 | GeneProduct | ncbigene:5609 | |
STAT3 | GeneProduct | ncbiprotein:NP_644805.1 | |
BAX | GeneProduct | ncbigene:581 | |
AMPK1 | GeneProduct | ncbigene:5562 | |
PARP1 | GeneProduct | ncbigene:142 | |
RPS6KB1 | GeneProduct | ncbigene:6198 | |
STAT3 | GeneProduct | ncbiprotein:NP_644805.1 | |
PRKCD | GeneProduct | ncbigene:5580 | |
IRAK1 | Protein | ncbigene:3654 | |
TRAF6 | Protein | ncbigene:7189 | |
IL18RAP | Protein | ncbigene:8807 | IL18RAP |
IL18 | Protein | ncbigene:3606 | |
IL18R1 | Protein | ncbigene:8809 | |
MYD88 | Protein | ncbigene:4615 | |
IL37 | Protein | ncbigene:27178 |
References
- A comprehensive pathway map of IL-18-mediated signalling. Rex DAB, Agarwal N, Prasad TSK, Kandasamy RK, Subbannayya Y, Pinto SM. J Cell Commun Signal. 2020 Jun;14(2):257–66. PubMed Europe PMC Scholia