Mitochondrial fatty acid synthesis pathway (WP4317)
Homo sapiens
Schematic presentation of the sequence of events. The indicated abbreviations follow the nomenclature used for the human enzymes and proteins. ACC, acetyl-CoA carboxylase; MCT, malonyl-CoA transferase; ACP, acyl-carrier protein; KAS, ketoacyl synthase; KAR, ketoacyl reductase; HTD2, hydroxyacyl-thioester reductase type 2; ETR, enoyl-thioester reductase. [J. Kastaniotis et al 2010]
Authors
Amadeo and Denise SlenterActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
citric acid cycle pathway classic metabolic pathway citric acid cycle pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| H | Metabolite | chebi:15378 | |
| Malonyl-CoA | Metabolite | hmdb:HMDB0001175 | |
| 3-Ketoacyl-ACP | Metabolite | chebi:57347 | |
| Malonyl-ACP | Metabolite | kegg.compound:C01209 | |
| Octanoyl-ACP | Metabolite | chebi:7725 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | The ChEBI ID with the correct charge is: 57288 |
| ATP | Metabolite | hmdb:HMDB0000538 | The ChEBI ID with the correct charge is: 30616 |
| CO2 | Metabolite | hmdb:HMDB0001967 | |
| ATP | Metabolite | hmdb:HMDB0000538 | The ChEBI ID with the correct charge is: 30616 |
| CO2 | Metabolite | hmdb:HMDB0001967 | |
| 3-Hydroxyacyl-ACP | Metabolite | chebi:57318 | |
| trans-2-Enoyl-ACP | Metabolite | kegg.compound:C05748 | |
| Acetyl/Acyl-ACP | Metabolite | wikidata:Q59811305 | |
| NADP | Metabolite | hmdb:HMDB0000217 | |
| NADPH | Metabolite | hmdb:HMDB0000221 | The ChEBI ID with the correct charge is: 57783 |
| water | Metabolite | hmdb:HMDB0002111 | |
| H | Metabolite | chebi:15378 | |
| NADP | Metabolite | hmdb:HMDB0000217 | |
| NADPH | Metabolite | hmdb:HMDB0000221 | The ChEBI ID with the correct charge is: 57783 |
| MECR | GeneProduct | ensembl:ENSG00000116353 | |
| HSD17B12 | GeneProduct | ensembl:ENSG00000149084 | |
| HTD2 | GeneProduct | ensembl:ENSG00000255154 | |
| ACACA | GeneProduct | ensembl:ENSG00000278540 | |
| MCAT | GeneProduct | ensembl:ENSG00000100294 | |
| KAS | GeneProduct | ensembl:ENSG00000151093 |
References
- Mitochondrial fatty acid synthesis and respiration. Hiltunen JK, Autio KJ, Schonauer MS, Kursu VAS, Dieckmann CL, Kastaniotis AJ. Biochim Biophys Acta. 2010;1797(6–7):1195–202. PubMed Europe PMC Scholia