Endoderm differentiation (WP3240)

Bos taurus

Model depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109

Authors

Martina Summer-Kutmon , Susan Coort , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
STAT1 GeneProduct ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115415
NANOG GeneProduct ensembl:ENSBTAG00000020916 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111704
PTHLH GeneProduct ensembl:ENSBTAG00000006538 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087494
EPB41L5 GeneProduct ensembl:ENSBTAG00000018236 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115109
LAMC1 GeneProduct ensembl:ENSBTAG00000011966 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135862
PRDM14 GeneProduct ensembl:ENSBTAG00000000060 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147596
SMAD3 GeneProduct ensembl:ENSBTAG00000012599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166949
RTF1 GeneProduct ensembl:ENSBTAG00000001671 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137815
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
NODAL GeneProduct ensembl:ENSBTAG00000013090 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000156574
BPTF GeneProduct ensembl:ENSBTAG00000014598 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171634
SOX17 GeneProduct ensembl:ENSBTAG00000005748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164736
GATA4 GeneProduct ensembl:ENSBTAG00000005425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136574
PAX9 GeneProduct ensembl:ENSBTAG00000009186 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198807
LEO1 GeneProduct ensembl:ENSBTAG00000013830 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166477
OTX2 GeneProduct ensembl:ENSBTAG00000014741 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165588
DAB2 GeneProduct ensembl:ENSBTAG00000016152 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000153071
SFRP1 GeneProduct ensembl:ENSBTAG00000027625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104332
GDF3 GeneProduct ensembl:ENSBTAG00000023192 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184344
NOTCH1 GeneProduct ensembl:ENSBTAG00000022799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148400
HOXA1 GeneProduct ensembl:ENSBTAG00000013263 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105991
EXT1 GeneProduct ensembl:ENSBTAG00000006209 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182197
PAF1 GeneProduct ensembl:ENSBTAG00000020428 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000006712
PABPC1 GeneProduct ensembl:ENSBTAG00000046358 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070756
EOMES GeneProduct ensembl:ENSBTAG00000016920 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163508
POU5F1 GeneProduct ensembl:ENSBTAG00000001873 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204531
ONECUT1 GeneProduct ensembl:ENSBTAG00000046470 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169856
FOXA1 GeneProduct ensembl:ENSBTAG00000013888 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129514
NKX2-1 GeneProduct ensembl:ENSBTAG00000000541 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136352
CTNNB1 GeneProduct ensembl:ENSBTAG00000016420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168036
TCF7 GeneProduct ensembl:ENSBTAG00000001002 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081059
MIXL1 GeneProduct ensembl:ENSBTAG00000002139 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185155
CTR9 GeneProduct ensembl:ENSBTAG00000015566 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198730
DUSP5 GeneProduct ensembl:ENSBTAG00000020283 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138166
SMAD4 GeneProduct ensembl:ENSBTAG00000006919 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141646
WNT8A GeneProduct ensembl:ENSBTAG00000005570 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000061492
ELAVL1 GeneProduct ensembl:ENSBTAG00000000613 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000066044
CER1 GeneProduct ensembl:ENSBTAG00000020140 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147869
FOXA2 GeneProduct ensembl:ENSBTAG00000012407 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125798
DKK1 GeneProduct ensembl:ENSBTAG00000014218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107984
APP GeneProduct ensembl:ENSBTAG00000017753 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142192
TNRC6C GeneProduct ensembl:ENSBTAG00000018658 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078687
BMPR-IA GeneProduct ensembl:ENSBTAG00000000231 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107779
TBX21 GeneProduct ensembl:ENSBTAG00000014199 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073861
SMAD2 GeneProduct ensembl:ENSBTAG00000039916 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175387
CAND1 GeneProduct ensembl:ENSBTAG00000009939 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111530
BMP7 GeneProduct ensembl:ENSBTAG00000015362 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101144
SOX2 GeneProduct ensembl:ENSBTAG00000011598 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181449
NOG GeneProduct ensembl:ENSBTAG00000040282 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183691
DUSP4 GeneProduct ensembl:ENSBTAG00000044208 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120875
CDC73 GeneProduct ensembl:ENSBTAG00000016703 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134371
LEF1 GeneProduct ensembl:ENSBTAG00000006844 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138795
HOXC11 GeneProduct ensembl:ENSBTAG00000006879 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123388
HHEX GeneProduct ensembl:ENSBTAG00000014217 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152804
GATA6 GeneProduct ensembl:ENSBTAG00000005734 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141448
JARID2 GeneProduct ensembl:ENSBTAG00000012938 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000008083
bta-mir-375 GeneProduct ensembl:ENSBTAG00000029763 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198973
bta-mir-141 GeneProduct ensembl:ENSBTAG00000036410 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207708
GR-A GeneProduct ensembl:ENSBTAG00000019472 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113580
DUSP2 GeneProduct ensembl:ENSBTAG00000020350 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158050
EZH2 GeneProduct ensembl:ENSBTAG00000009426 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106462
FOXH1 GeneProduct ensembl:ENSBTAG00000004761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160973
SIAH2 GeneProduct ensembl:ENSBTAG00000023445 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181788
RAB38 GeneProduct ensembl:ENSBTAG00000015793 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123892
APC GeneProduct ensembl:ENSBTAG00000018852 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134982
SOX7 GeneProduct ensembl:ENSBTAG00000046258 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171056
MAP2K3 GeneProduct ensembl:ENSBTAG00000010576 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000034152
WNT3 GeneProduct ensembl:ENSBTAG00000016012 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108379

References

  1. Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. Futaki S, Hayashi Y, Emoto T, Weber CN, Sekiguchi K. Mol Cell Biol. 2004 Dec;24(23):10492–503. PubMed Europe PMC Scholia
  2. Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, et al. Development. 2008 May;135(10):1791–801. PubMed Europe PMC Scholia
  3. Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Putzke AP, Rothman JH. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16154–9. PubMed Europe PMC Scholia
  4. Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Kim SW, Yoon SJ, Chuong E, Oyolu C, Wills AE, Gupta R, et al. Dev Biol. 2011 Sep 15;357(2):492–504. PubMed Europe PMC Scholia
  5. FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Sui L, Mfopou JK, Geens M, Sermon K, Bouwens L. Biochem Biophys Res Commun. 2012 Sep 28;426(3):380–5. PubMed Europe PMC Scholia
  6. MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7. Chappell J, Sun Y, Singh A, Dalton S. Genes Dev. 2013 Apr 1;27(7):725–33. PubMed Europe PMC Scholia
  7. Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development. Kang N, Won M, Rhee M, Ro H. Mol Cells. 2014 May;37(5):389–98. PubMed Europe PMC Scholia