Endochondral ossification (WP1270)

Mus musculus


Alex Pico , Egon Willighagen , Susan Coort , Friederike Ehrhart , and Eric Weitz


last edited

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Mus musculus



Pathway Ontology

regulatory pathway


Label Type Compact URI Comment
Oxygen Metabolite hmdb:HMDB0001377
Triiodothyronine Metabolite chebi:24864
Thyroid hormone Metabolite chebi:60311
cAMP Metabolite hmdb:HMDB0000058
Alpl GeneProduct ncbigene:11647
Spp1 GeneProduct ncbigene:20750
Fgfr3 GeneProduct ncbigene:14184
Mmp13 GeneProduct ncbigene:17386
Acan GeneProduct ncbigene:11595
Bmpr1a GeneProduct ncbigene:12166
Ihh GeneProduct ncbigene:16147
Fgfr1 GeneProduct ncbigene:14182
Igf2 GeneProduct ncbigene:16002
Bmp6 GeneProduct ncbigene:12161
Igf1 GeneProduct ncbigene:16000
Slc38a2 GeneProduct ncbigene:67760
Tgfb1 GeneProduct ncbigene:21803
Cab39 GeneProduct ncbigene:12283
Mef2c GeneProduct ncbigene:17260
Col2a1 GeneProduct ncbigene:12824
Adamts5 GeneProduct ncbigene:23794
Runx3 GeneProduct ncbigene:12399
Pth GeneProduct ncbigene:19226
Fgf18 GeneProduct ncbigene:14172
Calm1 GeneProduct ncbigene:12313
Scin GeneProduct ncbigene:20259 PMID: 17097081
Runx2 GeneProduct ncbigene:12393
Fgf2 GeneProduct ncbigene:14173
Sox6 GeneProduct ncbigene:20679
Ptch1 GeneProduct ncbigene:19206
Enpp1 GeneProduct ncbigene:18605
Prkaca GeneProduct ncbigene:18747
Kif3a GeneProduct ncbigene:16568
Ptch1 GeneProduct ncbigene:19206
Runx2 GeneProduct ncbigene:12393
Chst11 GeneProduct ncbigene:58250
Ctsl GeneProduct ncbigene:13039 Taken as homologue to mouse Cathepsin L (Ctsl)
Tgfb2 GeneProduct ncbigene:21808
Akt1 GeneProduct ncbigene:11651
Gli3 GeneProduct ncbigene:14634
Hmgcs1 GeneProduct ncbigene:208715
Vegfa GeneProduct ncbigene:22339
Mmp9 GeneProduct ncbigene:17395
Serpinh1 GeneProduct ncbigene:12406
Bmp7 GeneProduct ncbigene:12162
Cdkn1c GeneProduct ncbigene:12577
Sox9 GeneProduct ncbigene:20682
Thra GeneProduct ncbigene:21833
Runx2 GeneProduct ncbigene:12393
Stat1 GeneProduct ncbigene:20846
Adamts1 GeneProduct ncbigene:11504
Thra GeneProduct ncbigene:21833
Ghr GeneProduct ncbigene:14600
Plau GeneProduct ncbigene:18792
Mgp GeneProduct ncbigene:17313
Stat5b GeneProduct ncbigene:20851
Col10a1 GeneProduct ncbigene:12813
Adamts4 GeneProduct ncbigene:240913
Tgfb1 GeneProduct ncbigene:21803
Igf1r GeneProduct ncbigene:16001
Ift88 GeneProduct ncbigene:21821
Ddr2 GeneProduct ncbigene:18214
Nkx3-2 GeneProduct ncbigene:12020
Cst10 GeneProduct ncbigene:58214 Taken as human homologue of mouse Cst10
PMID: 13679380
Frzb GeneProduct ncbigene:20378
Plat GeneProduct ncbigene:18791
Hdac4 GeneProduct ncbigene:208727
Pthlh GeneProduct ncbigene:19227
Pth1r GeneProduct ncbigene:19228
Sox5 GeneProduct ncbigene:20678
Timp3 GeneProduct ncbigene:21859


  1. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M. Int J Biochem Cell Biol. 2008;40(1):46–62. PubMed Europe PMC Scholia
  2. A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage. Belluoccio D, Bernardo BC, Rowley L, Bateman JF. Biochim Biophys Acta. 2008 May;1779(5):330–40. PubMed Europe PMC Scholia