Integrin-mediated cell adhesion (WP185)

Homo sapiens

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Description reference: [[wikipedia:Integrins|Wikipedia]] Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Martijn Van Iersel , Thomas Kelder , Kristina Hanspers , Alex Pico , Zahra Roudbari , Martina Summer-Kutmon , Eric Weitz , and Egon Willighagen


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Homo sapiens


CPTAC PancCanNet


Pathway Ontology

integrin mediated signaling pathway


Label Type Compact URI Comment
ITGA4 GeneProduct ncbigene:3676
CAPN9 GeneProduct ncbigene:10753 CAPN9; calpain 9 (nCL-4) [EC:
ILK GeneProduct ncbigene:3611 ILK; integrin-linked kinase [EC:2.7.1.-]
PTK2 GeneProduct ncbigene:5747 PTK2; PTK2 protein tyrosine kinase 2 [EC:
ITGB3 GeneProduct ncbigene:3690
ITGAE GeneProduct ncbigene:3682
SOS1 GeneProduct ncbigene:6654 SOS1; son of sevenless homolog 1 (Drosophila)
ZYX GeneProduct ncbigene:7791 ZYX; zyxin
RAP1A GeneProduct ncbigene:5906 RAP1A; RAP1A member of RAS oncogene family
ITGAM GeneProduct ncbigene:3684
CRK GeneProduct ncbigene:1398 CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
ITGA7 GeneProduct ncbigene:3679
MIR34C GeneProduct ensembl:ENSG00000207562
ITGB7 GeneProduct ncbigene:3695
MYO-P GeneProduct ensembl:ENSG00000138347
CAPN5 GeneProduct ncbigene:726 CAPN5; calpain
ITGAD GeneProduct ncbigene:3681
SEPP1 GeneProduct ncbigene:6414 SEPP1; selenoprotein P plasma
ROCK1 GeneProduct ncbigene:6093 ROCK1; Rho-associated coiled-coil containing protein kinase
ITGAV GeneProduct ncbigene:3685
ITGA3 GeneProduct ncbigene:3675
VCL GeneProduct ncbigene:7414 VCL; vinculin
RAPGEF1 GeneProduct ncbigene:2889 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
ITGA2B GeneProduct ncbigene:3674
CAPN6 GeneProduct ncbigene:827 CAPN6; calpain 6 [EC:]
RAC2 GeneProduct ncbigene:5880 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
PXN GeneProduct ncbigene:5829 PXN; paxillin
PAK6 GeneProduct ncbigene:56924 PAK6; p21(CDKN1A)-activated kinase
MAP2K1 GeneProduct ncbigene:5604 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
BCAR1 GeneProduct ncbigene:9564 BCAR1; breast cancer anti-estrogen resistance 1
ITGB4 GeneProduct ncbigene:3691
ITGB8 GeneProduct ncbigene:3696
PDPK1 GeneProduct ncbigene:5170 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:]
CAPN3 GeneProduct ncbigene:825 CAPN3; calpain 3 (p94) [EC:]
SRC GeneProduct ncbigene:6714 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
DOCK1 GeneProduct ncbigene:1793 DOCK1; dedicator of cyto-kinesis
VAV3 GeneProduct ncbigene:10451 VAV3; vav 3 oncogene
BRAF GeneProduct ncbigene:673 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAV2 GeneProduct ncbigene:858 CAV2; caveolin 2
ITGAL GeneProduct ncbigene:3683
ARAF GeneProduct ncbigene:369 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
CAPN11 GeneProduct ncbigene:11131 CAPN11; calpain 11 [EC:]
CAPN10 GeneProduct ncbigene:11132 CAPN10; calpain 10 [EC:
ITGAX GeneProduct ncbigene:3687
ITGA1 GeneProduct ncbigene:3672
FYN GeneProduct ncbigene:2534 FYN; FYN oncogene related to SRC FGR YES [EC:]
MAPK10 GeneProduct ncbigene:5602
CSK GeneProduct ncbigene:1445 CSK; c-src tyrosine kinase [EC:]
CAV3 GeneProduct ncbigene:859 CAV3; caveolin 3
RHO GeneProduct ncbigene:6010 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
HRAS GeneProduct ncbigene:3265
MAPK7 GeneProduct ncbigene:5598 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
CAV1 GeneProduct ncbigene:857 CAV1; caveolin 1 caveolae protein 22kD
ITGB6 GeneProduct ncbigene:3694
MAPK6 GeneProduct ncbigene:5597 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
SHC1 GeneProduct ncbigene:6464 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
ITGB1 GeneProduct ncbigene:3688
CAPN2 GeneProduct ncbigene:824 CAPN2; calpain 2 (m/II) large subunit [EC:]
AKT3 GeneProduct ncbigene:10000 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
MAP2K2 GeneProduct ncbigene:5605 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
PIK3R2 GeneProduct ncbigene:5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
ITGA9 GeneProduct ncbigene:3680
TNS1 GeneProduct ncbigene:7145 TNS; tensi
CAPN7 GeneProduct ncbigene:23473 CAPN7; calpain 7 [EC:
ITGA5 GeneProduct ncbigene:3678
ITGA10 GeneProduct ncbigene:8515
RAF1 GeneProduct ncbigene:5894 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
VAV2 GeneProduct ncbigene:7410 VAV2; vav 2 oncogene
CDC42 GeneProduct ncbigene:998 CDC42; cell division cycle 42 (GTP binding protein 25kD)
MAP2K5 GeneProduct ncbigene:5607 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
CAPNS1 GeneProduct ncbigene:826 CAPNS1; calpain small subunit 1 [EC:]
ITGB2 GeneProduct ncbigene:3689
PAK2 GeneProduct ncbigene:5062 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
MAP2K3 GeneProduct ncbigene:5606 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAPK1 GeneProduct ncbigene:5594 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
SORBS1 GeneProduct ncbigene:10580 SH3D5; SH3-domain protein 5 (ponsin
RAP1B GeneProduct ncbigene:5908 RAP1B; RAP1B member of RAS oncogene family
SRC GeneProduct ncbigene:6714 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
MAP2K6 GeneProduct ncbigene:5608 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
PAK3 GeneProduct ncbigene:5063 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
ITGA2 GeneProduct ncbigene:3673
AKT2 GeneProduct ncbigene:208 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
CAPN1 GeneProduct ncbigene:823 CAPN1; calpain 1 (mu/I) large subunit [EC:]
RAC1 GeneProduct ncbigene:5879 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
ROCK2 GeneProduct ncbigene:9475 ROCK2; Rho-associated coiled-coil containing protein kinase
GIT2 GeneProduct ncbigene:9815 GIT2; G protein-coupled receptor kinase-interactor 2
VASP GeneProduct ncbigene:7408 VASP; vasodilator-stimulated phosphoprotein
ITGA6 GeneProduct ncbigene:3655
PAK1 GeneProduct ncbigene:5058 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
AKT1 GeneProduct ncbigene:207 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
GRB2 GeneProduct ncbigene:2885 GRB2; growth factor receptor-bound protein 2
ITGB5 GeneProduct ncbigene:3693
ITGA8 GeneProduct ncbigene:8516
ITGA11 GeneProduct ncbigene:22801
ARHGEF7 GeneProduct ncbigene:8874 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
MYLK2 GeneProduct ncbigene:85366 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
PAK4 GeneProduct ncbigene:10298 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
MAPK4 GeneProduct ncbigene:5596 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK12 GeneProduct ncbigene:6300 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
RAC3 GeneProduct ncbigene:5881 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
TLN1 GeneProduct ncbigene:7094 TLN1; talin 1
SHC3 GeneProduct ncbigene:53358 SHC3; neuronal Sh
PTK2 GeneProduct ncbigene:5747 PTK2; PTK2 protein tyrosine kinase 2 [EC:


  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia
  2. The miR-34 family in cancer and apoptosis. Hermeking H. Cell Death Differ. 2010 Feb;17(2):193–9. PubMed Europe PMC Scholia