Cholesterol biosynthesis (WP1070)
Bos taurus
Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]]
Authors
Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , Kristina Hanspers , Egon Willighagen , and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
cholesterol biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| (S)-2,3-Epoxysqualene | Metabolite | chebi:15441 | |
| Mevalonic acid | Metabolite | cas:150-97-0 | |
| farnesyl pyrophosphate | Metabolite | cas:13058-04-3 | |
| Lathosterol | Metabolite | cas:80-99-9 | |
| Lanosterin | Metabolite | cas:79-63-0 | |
| Mevalonic acid 5-pyrophosphate | Metabolite | cas:1492-08-6 | |
| 7-Dehydrocholesterol | Metabolite | cas:434-16-2 | |
| isopentenyl pyrophosphate | Metabolite | cas:358-71-4 | |
| HMG-CoA | Metabolite | hmdb:HMDB0001375 | |
| Geranyl-PP | Metabolite | cas:6699-20-3 | |
| Cholesterol | Metabolite | cas:57-88-5 | |
| Mevalonic acid-5P | Metabolite | cas:73566-35-5 | |
| Squalene | Metabolite | cas:111-02-4 | |
| Acetyl-CoA | Metabolite | cas:72-89-9 | |
| Dimethylallylpyrophosphate | Metabolite | cas:358-72-5 | |
| NSDHL | GeneProduct | ensembl:ENSBTAG00000009231 | NAD(P) dependent steroid dehydrogenase-likeHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50814 |
| FDPS | GeneProduct | ensembl:ENSBTAG00000003948 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2224 |
| HMGCS1 | GeneProduct | ensembl:ENSBTAG00000011839 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3157 |
| SC4MOL | GeneProduct | ensembl:ENSBTAG00000003068 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6307 |
| SQLE | GeneProduct | ensembl:ENSBTAG00000005498 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713 |
| IDI1 | GeneProduct | ensembl:ENSBTAG00000004075 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3422 |
| MVD | GeneProduct | ensembl:ENSBTAG00000012059 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4597 |
| CYP51A1 | GeneProduct | ensembl:ENSBTAG00000001992 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1595 |
| HMGCR | GeneProduct | ensembl:ENSBTAG00000007840 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156 |
| DHCR7 | GeneProduct | ensembl:ENSBTAG00000016465 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1717 |
| PMVK | GeneProduct | ensembl:ENSBTAG00000017819 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10654 |
| FDPS | GeneProduct | ensembl:ENSBTAG00000003948 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2224 |
| SC5DL | GeneProduct | ensembl:ENSBTAG00000019246 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6309 |
| FDFT1 | GeneProduct | ensembl:ENSBTAG00000012432 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222 |
| LSS | GeneProduct | ensembl:ENSBTAG00000018936 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4047 |
| MVK | GeneProduct | ensembl:ENSBTAG00000005183 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4598 |