Cholesterol biosynthesis (WP1070)

Bos taurus

Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it is required to establish proper membrane permeability and fluidity. In addition, cholesterol is an important component for the manufacture of bile acids, steroid hormones, and several fat-soluble vitamins. Cholesterol is the principal sterol synthesized by animals, but small quantities are synthesized in other eukaryotes, such as plants and fungi. It is almost completely absent among prokaryotes, which include bacteria. Source: [[wikipedia:Cholesterol|Wikipedia]]

Authors

Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

cholesterol biosynthetic pathway

Participants

Label Type Compact URI Comment
(S)-2,3-Epoxysqualene Metabolite chebi:15441
Mevalonic acid Metabolite cas:150-97-0
farnesyl pyrophosphate Metabolite cas:13058-04-3
Lathosterol Metabolite cas:80-99-9
Lanosterin Metabolite cas:79-63-0
Mevalonic acid 5-pyrophosphate Metabolite cas:1492-08-6
7-Dehydrocholesterol Metabolite cas:434-16-2
isopentenyl pyrophosphate Metabolite cas:358-71-4
HMG-CoA Metabolite hmdb:HMDB0001375
Geranyl-PP Metabolite cas:6699-20-3
Cholesterol Metabolite cas:57-88-5
Mevalonic acid-5P Metabolite cas:73566-35-5
Squalene Metabolite cas:111-02-4
Acetyl-CoA Metabolite cas:72-89-9
Dimethylallylpyrophosphate Metabolite cas:358-72-5
NSDHL GeneProduct ensembl:ENSBTAG00000009231 NAD(P) dependent steroid dehydrogenase-like
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50814
FDPS GeneProduct ensembl:ENSBTAG00000003948 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2224
HMGCS1 GeneProduct ensembl:ENSBTAG00000011839 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3157
SC4MOL GeneProduct ensembl:ENSBTAG00000003068 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6307
SQLE GeneProduct ensembl:ENSBTAG00000005498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713
IDI1 GeneProduct ensembl:ENSBTAG00000004075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3422
MVD GeneProduct ensembl:ENSBTAG00000012059 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4597
CYP51A1 GeneProduct ensembl:ENSBTAG00000001992 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1595
HMGCR GeneProduct ensembl:ENSBTAG00000007840 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156
DHCR7 GeneProduct ensembl:ENSBTAG00000016465 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1717
PMVK GeneProduct ensembl:ENSBTAG00000017819 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10654
SC5DL GeneProduct ensembl:ENSBTAG00000019246 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6309
FDFT1 GeneProduct ensembl:ENSBTAG00000012432 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222
LSS GeneProduct ensembl:ENSBTAG00000018936 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4047
MVK GeneProduct ensembl:ENSBTAG00000005183 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4598

References