Burn wound healing (WP5055)

Homo sapiens

Authors

Maximilian Saller , Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

fibroblast endothelial cell keratinocyte myofibroblast cell

Pathway Ontology

immune response pathway cell-extracellular matrix signaling pathway

References

1. Value of radioisotopes in the detection of phlebitis. Simon JP, Guiraud RF. Nouv Presse Med. 1976;5(28):1747–9. PubMed Europe PMC Scholia
2. Glycosaminoglycan content in the media of cultured dermal fibroblasts derived from burn scar and normal skin. Nogami R, Maekawa Y, Kudo S. J Dermatol. 1989 Feb;16(1):42–6. PubMed Europe PMC Scholia
3. Distributions of melanoma growth stimulatory activity of growth-regulated gene and the interleukin-8 receptor B in human wound repair. Nanney LB, Mueller SG, Bueno R, Peiper SC, Richmond A. Am J Pathol. 1995 Nov;147(5):1248–60. PubMed Europe PMC Scholia
4. Similar ectopic expression of ICAM-1 and HLA class II molecules in hypertrophic scars following thermal injury. Castagnoli C, Stella M, Magliacani G, Ferrone S, Richiardi PM. Burns. 1994 Oct;20(5):430–3. PubMed Europe PMC Scholia
5. Expression and role of IL-15 in post-burn hypertrophic scars. Castagnoli C, Trombotto C, Ariotti S, Millesimo M, Ravarino D, Magliacani G, et al. J Invest Dermatol. 1999 Aug;113(2):238–45. PubMed Europe PMC Scholia
6. Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars. Costa AM, Peyrol S, Pôrto LC, Comparin JP, Foyatier JL, Desmoulière A. Am J Pathol. 1999 Nov;155(5):1671–9. PubMed Europe PMC Scholia
7. Keratinocyte differentiation inversely regulates the expression of involucrin and transforming growth factor beta1. Ghahary A, Marcoux Y, Karimi-Busheri F, Tredget EE. J Cell Biochem. 2001 Aug 1;83(2):239–48. PubMed Europe PMC Scholia
8. Myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b. Nedelec B, Shankowsky H, Scott PG, Ghahary A, Tredget EE. Surgery. 2001 Nov;130(5):798–808. PubMed Europe PMC Scholia
9. Immunolocalization of fibroblast growth factor receptors in normal and wounded human skin. Takenaka H, Yasuno H, Kishimoto S. Arch Dermatol Res. 2002 Oct;294(7):331–8. PubMed Europe PMC Scholia
10. Dermal fibroblasts from different layers of human skin are heterogeneous in expression of collagenase and types I and III procollagen mRNA. Ali-Bahar M, Bauer B, Tredget EE, Ghahary A. Wound Repair Regen. 2004;12(2):175–82. PubMed Europe PMC Scholia
11. A study of p53 expression in thermal burns of human skin for determination of wound age. Tarran S, Dziewulski P, Sztynda T, Langlois NEI. Med Sci Law. 2004 Jul;44(3):222–6. PubMed Europe PMC Scholia
12. Gene expression of early hypertrophic scar tissue screened by means of cDNA microarrays. Wu J, Ma B, Yi S, Wang Z, He W, Luo G, et al. J Trauma. 2004 Dec;57(6):1276–86. PubMed Europe PMC Scholia
13. Effect of in vitro mechanical compression on Epilysin (matrix metalloproteinase-28) expression in hypertrophic scars. Renò F, Sabbatini M, Stella M, Magliacani G, Cannas M. Wound Repair Regen. 2005;13(3):255–61. PubMed Europe PMC Scholia
14. Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation. Colwell AS, Phan TT, Kong W, Longaker MT, Lorenz PH. Plast Reconstr Surg. 2005 Oct;116(5):1387–90; discussion 1391-2. PubMed Europe PMC Scholia
15. Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns. Avniel S, Arik Z, Maly A, Sagie A, Basst HB, Yahana MD, et al. J Invest Dermatol. 2006 Feb;126(2):468–76. PubMed Europe PMC Scholia
16. Autocrine production of biologically active hepatocyte growth factor (HGF) by injured human skin. Nayeri F, Xu J, Abdiu A, Nayeri T, Aili D, Liedberg B, et al. J Dermatol Sci. 2006 Jul;43(1):49–56. PubMed Europe PMC Scholia
17. Proteolytic activity in human burn wounds. Neely AN, Brown RL, Clendening CE, Orloff MM, Gardner J, Greenhalgh DG. Wound Repair Regen. 1997;5(4):302–9. PubMed Europe PMC Scholia
18. Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin. Fumagalli M, Musso T, Vermi W, Scutera S, Daniele R, Alotto D, et al. Exp Dermatol. 2007 Jul;16(7):600–10. PubMed Europe PMC Scholia
19. Temporal expression of activin in acute burn wounds--from inflammatory cells to fibroblasts. McLean CA, Cleland H, Moncrieff NJ, Barton RJ, de Kretser DM, Phillips DJ. Burns. 2008 Feb;34(1):50–5. PubMed Europe PMC Scholia
20. Improved scar in postburn patients following interferon-alpha2b treatment is associated with decreased angiogenesis mediated by vascular endothelial cell growth factor. Wang J, Chen H, Shankowsky HA, Scott PG, Tredget EE. J Interferon Cytokine Res. 2008 Jul;28(7):423–34. PubMed Europe PMC Scholia
21. Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring. Wang J, Hori K, Ding J, Huang Y, Kwan P, Ladak A, et al. J Cell Physiol. 2011 May;226(5):1265–73. PubMed Europe PMC Scholia
22. Stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 in the formation of postburn hypertrophic scar (HTS). Ding J, Hori K, Zhang R, Marcoux Y, Honardoust D, Shankowsky HA, et al. Wound Repair Regen. 2011;19(5):568–78. PubMed Europe PMC Scholia
23. Development of a vascularized skin construct using adipose-derived stem cells from debrided burned skin. Chan RK, Zamora DO, Wrice NL, Baer DG, Renz EM, Christy RJ, et al. Stem Cells Int. 2012;2012:841203. PubMed Europe PMC Scholia
24. SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars. Chen L, Wang Z, Li S, Zhao G, Tian M, Sun Z. PLoS One. 2012;7(12):e50229. PubMed Europe PMC Scholia
25. MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. Kwan P, Ding J, Tredget EE. PLoS One. 2015 Apr 2;10(4):e0123054. PubMed Europe PMC Scholia
26. miR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity. Gras C, Ratuszny D, Hadamitzky C, Zhang H, Blasczyk R, Figueiredo C. Mol Med. 2015 Apr 9;21(1):296–304. PubMed Europe PMC Scholia
27. Protomyofibroblast Pathway in Early Thermal Burn Healing. Hermanns-Lê T, Piérard GE, Jennes S, Piérard-Franchimont C. Skin Pharmacol Physiol. 2015;28(5):250–4. PubMed Europe PMC Scholia
28. Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, et al. Biol Open. 2016 Jan 21;5(3):211–9. PubMed Europe PMC Scholia
29. Imaging mass spectrometry for accessing molecular changes during burn wound healing. Taverna D, Pollins AC, Sindona G, Caprioli RM, Nanney LB. Wound Repair Regen. 2016 Sep;24(5):775–85. PubMed Europe PMC Scholia
30. Overexpression of miR-29b reduces collagen biosynthesis by inhibiting heat shock protein 47 during skin wound healing. Zhu Y, Li Z, Wang Y, Li L, Wang D, Zhang W, et al. Transl Res. 2016 Dec;178:38-53.e6. PubMed Europe PMC Scholia
31. Burn Injury Alters Epidermal Cholinergic Mediators and Increases HMGB1 and Caspase 3 in Autologous Donor Skin and Burn Margin. Holmes CJ, Plichta JK, Gamelli RL, Radek KA. Shock. 2017 Feb;47(2):175–83. PubMed Europe PMC Scholia
32. Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation. Ijaz T, Jamaluddin M, Zhao Y, Zhang Y, Jay J, Finnerty CC, et al. Cell Death Dis. 2017 Feb 9;8(2):e2606. PubMed Europe PMC Scholia
33. Role of XIST/miR-29a/LIN28A pathway in denatured dermis and human skin fibroblasts (HSFs) after thermal injury. Guo L, Huang X, Liang P, Zhang P, Zhang M, Ren L, et al. J Cell Biochem. 2018 Feb;119(2):1463–74. PubMed Europe PMC Scholia
34. LncRNA XIST promotes extracellular matrix synthesis, proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury. Cao W, Feng Y. Biol Res. 2019 Sep 20;52(1):52. PubMed Europe PMC Scholia
35. Down-regulation of long non-coding RNA HOTAIR promotes angiogenesis via regulating miR-126/SCEL pathways in burn wound healing. Jiang B, Tang Y, Wang H, Chen C, Yu W, Sun H, et al. Cell Death Dis. 2020 Jan 23;11(1):61. PubMed Europe PMC Scholia
36. Characterization of Burn Eschar Pericytes. Evdokiou A, Kanisicak O, Gierek S, Barry A, Ivey MJ, Zhang X, et al. J Clin Med. 2020 Feb 24;9(2):606. PubMed Europe PMC Scholia
37. Identification of differentially expressed miRNAs associated with thermal injury in epidermal stem cells based on RNA-sequencing. Rong HT, Liu DW. Exp Ther Med. 2020 Mar;19(3):2218–28. PubMed Europe PMC Scholia
38. Galectin-1 production is elevated in hypertrophic scar. Kirkpatrick LD, Shupp JW, Smith RD, Alkhalil A, Moffatt LT, Carney BC. Wound Repair Regen. 2021 Jan;29(1):117–28. PubMed Europe PMC Scholia
39. Long non-coding RNA HULC regulates TLR4 expression by acting as ceRNA to attract miR-663b in skin fibroblasts of pediatric burns. Liu Y, Qi X, Zhou Y. Am J Transl Res. 2021 Apr 15;13(4):2499–510. PubMed Europe PMC Scholia
40. Long non-coding RNA TPT1-AS1 alleviates cell injury and promotes the production of extracellular matrix by targeting the microRNA-324-5p/CDK16 axis in human dermal fibroblasts after thermal injury. Luo J, You H, Zhan J, Guo G, Cheng X, Zheng G. Exp Ther Med. 2021 Aug;22(2):843. PubMed Europe PMC Scholia