Burn wound healing (WP5055)

Homo sapiens

This pathway is part of a systematic review on currently known molecular players in burn wound healing in mammalians.


Maximilian Saller , Kristina Hanspers , Egon Willighagen , and Eric Weitz


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Homo sapiens



Cell Type Ontology

fibroblast endothelial cell keratinocyte myofibroblast cell

Pathway Ontology

immune response pathway cell-extracellular matrix signaling pathway


Label Type Compact URI Comment
LPS Metabolite pubchem.substance:53481794
PGE2 Metabolite hmdb:HMDB0060041
ACh Metabolite hmdb:HMDB0000895
Sulfate Metabolite hmdb:HMDB0001448
FST GeneProduct uniprot:P19883
PGS2 Protein uniprot:P07585 delayed expression
EGF Protein uniprot:P01133
GROA Protein uniprot:P09341
TLR4 Protein uniprot:O00206 pericytes
IL8 Protein uniprot:P10145 pericytes
IL6 Protein uniprot:P05231 pericytes
CCL2 Protein uniprot:P13500 pericytes
MYD88 Protein uniprot:Q99836 pericytes
PGS2 Protein uniprot:P07585
ACHA7 Protein uniprot:P36544
ACES Protein uniprot:P22303
LN28A Protein uniprot:Q9H9Z2
SCEL Protein uniprot:O95171
VEGFA Protein uniprot:P15692
COL1A2 Protein uniprot:P08123
MMP9 Protein uniprot:P14780
TGFB2 Protein uniprot:P61812
TGFB3 Protein uniprot:P10600
COL1A1 Protein uniprot:P02452
INHBA Protein uniprot:P08476 = Activin A = EDF
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AKT1 Protein uniprot:P31749
CXCR4 Protein uniprot:P61073
CXCL12 Protein uniprot:P48061 SDF1
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SMAD3 Protein uniprot:P84022
BRD4 Protein uniprot:O60885
NOX4 Protein uniprot:Q9NPH5
IFNA2 Protein uniprot:P01563
KLF4 Protein uniprot:O43474
BCL2 Protein uniprot:P10415
SFRP2 Protein uniprot:Q96HF1
SNAI2 Protein uniprot:O43623
IFNB1 Protein uniprot:P01574
PECAM1 Protein uniprot:P16284 CD31
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ACTA1 Protein uniprot:P68133
SERPINH1 Protein uniprot:P50454
NFKB1 Protein uniprot:P19838
TGFB1 Protein uniprot:P01137
IL1B Protein uniprot:P01584
TNF Protein uniprot:P01375
COL1A1 Protein uniprot:P02452
MIR29B1 Protein ensembl:ENSG00000283797
FBN1 Protein uniprot:P35555
TNC Protein uniprot:P24821
ELN Protein uniprot:P15502
ICAM1 Protein uniprot:P05362
CXCR2 Protein uniprot:P25025
TAGL Protein uniprot:Q01995 pericytes
FOXE1 Protein uniprot:O00358 pericytes
FILA Protein uniprot:P20930 pericytes
K2C6A Protein uniprot:P02538 pericytes
MMP28 Protein uniprot:Q9H239 pericytes
MMP2 Protein uniprot:P08253 pericytes
S10A6 Protein uniprot:P06703
S10A9 Protein uniprot:P06702
S10AB Protein uniprot:P31949
SLUR1 Protein uniprot:P55000
HMGB1 Protein uniprot:P09429
CASP3 Protein uniprot:P42574
SFRP2 Protein uniprot:Q96HF1 Fibroblasts
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SNAI2 Protein uniprot:O43623 Fibroblasts
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PECAM1 Protein uniprot:P16284
SERPINH1 Protein uniprot:P50454 HSP47
bsmA Protein uniprot:P39297
F13A1 Protein uniprot:P00488
FGFR1 Protein uniprot:P11362
FGFR2 Protein uniprot:P21802
FGFR3 Protein uniprot:P22607
FGFR4 Protein uniprot:P22455
CD3E Protein uniprot:P07766 Fibroblasts
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IL15 Protein uniprot:P40933 Fibroblasts
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HGF Protein uniprot:P14210
CXCR4 Protein uniprot:P61073 Fibroblasts
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Cspg4 Protein uniprot:Q8VHY0
PDGFRb Protein uniprot:P09619
Krt222 Protein uniprot:Q8N1A0
TP53 Protein uniprot:P04637
HEXD Protein uniprot:Q8WVB3
AMBP Protein uniprot:P02760 Uronic acid
Type your comment here
NOTCH2 Protein uniprot:Q9QW30
MMP7 Protein uniprot:P50280
JAG2 Protein uniprot:P97607
LGLAS1 Protein uniprot:P09382
MMP1 Protein uniprot:P03956
TIMP1 Protein uniprot:P01033
TPT1 Protein uniprot:P13693
BAX Protein uniprot:Q07812
CASP3 Protein uniprot:P42574
CDK16 Protein uniprot:Q00536


  1. Value of radioisotopes in the detection of phlebitis. Simon JP, Guiraud RF. Nouv Presse Med. 1976;5(28):1747–9. PubMed Europe PMC Scholia
  2. Glycosaminoglycan content in the media of cultured dermal fibroblasts derived from burn scar and normal skin. Nogami R, Maekawa Y, Kudo S. J Dermatol. 1989 Feb;16(1):42–6. PubMed Europe PMC Scholia
  3. Distributions of melanoma growth stimulatory activity of growth-regulated gene and the interleukin-8 receptor B in human wound repair. Nanney LB, Mueller SG, Bueno R, Peiper SC, Richmond A. Am J Pathol. 1995 Nov;147(5):1248–60. PubMed Europe PMC Scholia
  4. Similar ectopic expression of ICAM-1 and HLA class II molecules in hypertrophic scars following thermal injury. Castagnoli C, Stella M, Magliacani G, Ferrone S, Richiardi PM. Burns. 1994 Oct;20(5):430–3. PubMed Europe PMC Scholia
  5. Expression and role of IL-15 in post-burn hypertrophic scars. Castagnoli C, Trombotto C, Ariotti S, Millesimo M, Ravarino D, Magliacani G, et al. J Invest Dermatol. 1999 Aug;113(2):238–45. PubMed Europe PMC Scholia
  6. Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars. Costa AM, Peyrol S, Pôrto LC, Comparin JP, Foyatier JL, Desmoulière A. Am J Pathol. 1999 Nov;155(5):1671–9. PubMed Europe PMC Scholia
  7. Keratinocyte differentiation inversely regulates the expression of involucrin and transforming growth factor beta1. Ghahary A, Marcoux Y, Karimi-Busheri F, Tredget EE. J Cell Biochem. 2001 Aug 1;83(2):239–48. PubMed Europe PMC Scholia
  8. Myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b. Nedelec B, Shankowsky H, Scott PG, Ghahary A, Tredget EE. Surgery. 2001 Nov;130(5):798–808. PubMed Europe PMC Scholia
  9. Immunolocalization of fibroblast growth factor receptors in normal and wounded human skin. Takenaka H, Yasuno H, Kishimoto S. Arch Dermatol Res. 2002 Oct;294(7):331–8. PubMed Europe PMC Scholia
  10. Dermal fibroblasts from different layers of human skin are heterogeneous in expression of collagenase and types I and III procollagen mRNA. Ali-Bahar M, Bauer B, Tredget EE, Ghahary A. Wound Repair Regen. 2004;12(2):175–82. PubMed Europe PMC Scholia
  11. A study of p53 expression in thermal burns of human skin for determination of wound age. Tarran S, Dziewulski P, Sztynda T, Langlois NEI. Med Sci Law. 2004 Jul;44(3):222–6. PubMed Europe PMC Scholia
  12. Gene expression of early hypertrophic scar tissue screened by means of cDNA microarrays. Wu J, Ma B, Yi S, Wang Z, He W, Luo G, et al. J Trauma. 2004 Dec;57(6):1276–86. PubMed Europe PMC Scholia
  13. Effect of in vitro mechanical compression on Epilysin (matrix metalloproteinase-28) expression in hypertrophic scars. Renò F, Sabbatini M, Stella M, Magliacani G, Cannas M. Wound Repair Regen. 2005;13(3):255–61. PubMed Europe PMC Scholia
  14. Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation. Colwell AS, Phan TT, Kong W, Longaker MT, Lorenz PH. Plast Reconstr Surg. 2005 Oct;116(5):1387–90; discussion 1391-2. PubMed Europe PMC Scholia
  15. Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns. Avniel S, Arik Z, Maly A, Sagie A, Basst HB, Yahana MD, et al. J Invest Dermatol. 2006 Feb;126(2):468–76. PubMed Europe PMC Scholia
  16. Autocrine production of biologically active hepatocyte growth factor (HGF) by injured human skin. Nayeri F, Xu J, Abdiu A, Nayeri T, Aili D, Liedberg B, et al. J Dermatol Sci. 2006 Jul;43(1):49–56. PubMed Europe PMC Scholia
  17. Proteolytic activity in human burn wounds. Neely AN, Brown RL, Clendening CE, Orloff MM, Gardner J, Greenhalgh DG. Wound Repair Regen. 1997;5(4):302–9. PubMed Europe PMC Scholia
  18. Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin. Fumagalli M, Musso T, Vermi W, Scutera S, Daniele R, Alotto D, et al. Exp Dermatol. 2007 Jul;16(7):600–10. PubMed Europe PMC Scholia
  19. Temporal expression of activin in acute burn wounds--from inflammatory cells to fibroblasts. McLean CA, Cleland H, Moncrieff NJ, Barton RJ, de Kretser DM, Phillips DJ. Burns. 2008 Feb;34(1):50–5. PubMed Europe PMC Scholia
  20. Improved scar in postburn patients following interferon-alpha2b treatment is associated with decreased angiogenesis mediated by vascular endothelial cell growth factor. Wang J, Chen H, Shankowsky HA, Scott PG, Tredget EE. J Interferon Cytokine Res. 2008 Jul;28(7):423–34. PubMed Europe PMC Scholia
  21. Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring. Wang J, Hori K, Ding J, Huang Y, Kwan P, Ladak A, et al. J Cell Physiol. 2011 May;226(5):1265–73. PubMed Europe PMC Scholia
  22. Stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 in the formation of postburn hypertrophic scar (HTS). Ding J, Hori K, Zhang R, Marcoux Y, Honardoust D, Shankowsky HA, et al. Wound Repair Regen. 2011;19(5):568–78. PubMed Europe PMC Scholia
  23. Development of a vascularized skin construct using adipose-derived stem cells from debrided burned skin. Chan RK, Zamora DO, Wrice NL, Baer DG, Renz EM, Christy RJ, et al. Stem Cells Int. 2012;2012:841203. PubMed Europe PMC Scholia
  24. SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars. Chen L, Wang Z, Li S, Zhao G, Tian M, Sun Z. PLoS One. 2012;7(12):e50229. PubMed Europe PMC Scholia
  25. MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. Kwan P, Ding J, Tredget EE. PLoS One. 2015 Apr 2;10(4):e0123054. PubMed Europe PMC Scholia
  26. miR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity. Gras C, Ratuszny D, Hadamitzky C, Zhang H, Blasczyk R, Figueiredo C. Mol Med. 2015 Apr 9;21(1):296–304. PubMed Europe PMC Scholia
  27. Protomyofibroblast Pathway in Early Thermal Burn Healing. Hermanns-Lê T, Piérard GE, Jennes S, Piérard-Franchimont C. Skin Pharmacol Physiol. 2015;28(5):250–4. PubMed Europe PMC Scholia
  28. Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury. Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, et al. Biol Open. 2016 Jan 21;5(3):211–9. PubMed Europe PMC Scholia
  29. Imaging mass spectrometry for accessing molecular changes during burn wound healing. Taverna D, Pollins AC, Sindona G, Caprioli RM, Nanney LB. Wound Repair Regen. 2016 Sep;24(5):775–85. PubMed Europe PMC Scholia
  30. Overexpression of miR-29b reduces collagen biosynthesis by inhibiting heat shock protein 47 during skin wound healing. Zhu Y, Li Z, Wang Y, Li L, Wang D, Zhang W, et al. Transl Res. 2016 Dec;178:38-53.e6. PubMed Europe PMC Scholia
  31. Burn Injury Alters Epidermal Cholinergic Mediators and Increases HMGB1 and Caspase 3 in Autologous Donor Skin and Burn Margin. Holmes CJ, Plichta JK, Gamelli RL, Radek KA. Shock. 2017 Feb;47(2):175–83. PubMed Europe PMC Scholia
  32. Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation. Ijaz T, Jamaluddin M, Zhao Y, Zhang Y, Jay J, Finnerty CC, et al. Cell Death Dis. 2017 Feb 9;8(2):e2606. PubMed Europe PMC Scholia
  33. Role of XIST/miR-29a/LIN28A pathway in denatured dermis and human skin fibroblasts (HSFs) after thermal injury. Guo L, Huang X, Liang P, Zhang P, Zhang M, Ren L, et al. J Cell Biochem. 2018 Feb;119(2):1463–74. PubMed Europe PMC Scholia
  34. LncRNA XIST promotes extracellular matrix synthesis, proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury. Cao W, Feng Y. Biol Res. 2019 Sep 20;52(1):52. PubMed Europe PMC Scholia
  35. Down-regulation of long non-coding RNA HOTAIR promotes angiogenesis via regulating miR-126/SCEL pathways in burn wound healing. Jiang B, Tang Y, Wang H, Chen C, Yu W, Sun H, et al. Cell Death Dis. 2020 Jan 23;11(1):61. PubMed Europe PMC Scholia
  36. Characterization of Burn Eschar Pericytes. Evdokiou A, Kanisicak O, Gierek S, Barry A, Ivey MJ, Zhang X, et al. J Clin Med. 2020 Feb 24;9(2):606. PubMed Europe PMC Scholia
  37. Identification of differentially expressed miRNAs associated with thermal injury in epidermal stem cells based on RNA-sequencing. Rong HT, Liu DW. Exp Ther Med. 2020 Mar;19(3):2218–28. PubMed Europe PMC Scholia
  38. Galectin-1 production is elevated in hypertrophic scar. Kirkpatrick LD, Shupp JW, Smith RD, Alkhalil A, Moffatt LT, Carney BC. Wound Repair Regen. 2021 Jan;29(1):117–28. PubMed Europe PMC Scholia
  39. Long non-coding RNA HULC regulates TLR4 expression by acting as ceRNA to attract miR-663b in skin fibroblasts of pediatric burns. Liu Y, Qi X, Zhou Y. Am J Transl Res. 2021 Apr 15;13(4):2499–510. PubMed Europe PMC Scholia
  40. Long non-coding RNA TPT1-AS1 alleviates cell injury and promotes the production of extracellular matrix by targeting the microRNA-324-5p/CDK16 axis in human dermal fibroblasts after thermal injury. Luo J, You H, Zhan J, Guo G, Cheng X, Zheng G. Exp Ther Med. 2021 Aug;22(2):843. PubMed Europe PMC Scholia