Osteoclast signaling (WP12)

Homo sapiens

Open in new tab Open in NDEx
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Signaling pathways involved in osteoclast activation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP12 CPTAC Assay Portal]

Authors

Ed Hsiao , Alex Pico , Samuel Sklar , Kristina Hanspers , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Jesse Vercoulen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway signaling pathway pertinent to development

Cell Type Ontology

osteoclast

Participants
Query Drugst.One

Label Type Compact URI Comment
Ca2+ Metabolite pubchem.compound:271
H+ Metabolite pubchem.compound:1038
Pi Metabolite chebi:35780
H+ Metabolite pubchem.compound:1038
Ca2+ Metabolite pubchem.compound:271
H+ Metabolite pubchem.compound:1038
H+ Metabolite pubchem.compound:1038
H+ Metabolite pubchem.compound:1038
Na+ Metabolite hmdb:HMDB0000588
Na+ Metabolite hmdb:HMDB0000588
AIMP2 GeneProduct ensembl:ENSG00000106305
MAPK8 GeneProduct ensembl:ENSG00000107643
OPG Protein ncbigene:4982
PDGFB Protein ncbigene:5155
TRPV Protein ncbigene:56302
RANK ligand Protein ncbigene:8600
TRAP Protein ncbigene:54
Cathepsin K Protein ncbigene:1513
IFN-b Protein ncbigene:3456
Na+/H+ transporter Protein ncbigene:6548
H+ ATPase Protein ncbigene:9550
RANK Protein ncbigene:8792
TRAP Protein ncbigene:54
Type 1 interferon receptor Protein ncbigene:3454
b3 integrin Protein ncbigene:3690
Cathepsin K Protein ncbigene:1513
OGR1 Protein ncbigene:8111
Osteopontin Protein ncbigene:6696
PDGFB Protein ncbigene:5155

References

  1. Osteoclast differentiation and activation. Boyle WJ, Simonet WS, Lacey DL. Nature. 2003 May 15;423(6937):337–42. PubMed Europe PMC Scholia