Phosphatidic acid and phospholipid biosynthesis (WP472)

Saccharomyces cerevisiae

Chorismate is an intermediate in the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan and the vitamins, p-aminobenzoate and p-hydroxybenzoate (CITS:[Jones]). The series of reactions to chorismate, called the shikimate pathway, are common for all of the aforementioned compounds, at which point the pathway branches (CITS:[Jones][1943992]). One branch proceeds to tryptophan, one to phenylalanine and tyrosine, one to p-aminobenzoate, and one to p-hydroxybenzoate (CITS:[Jones][ 1943992]). Aromatic amino acid biosynthesis in S. cerevisiae is controlled by a combination of feedback inhibition, activation of enzyme activity, and regulation of enzyme synthesis (CITS:[Jones][1943992]). The carbon flow through the pathways is regulated primarily at the initial step and the branching points by the terminal end-products. The initial step of chorismate biosynthesis can be catalyzed by two isoenzymes, one of which (ARO3) is inhibited by phenylalanine, and the other (ARO4) by tyrosine (CITS:[Jones][1943992]). The first step in the phenylalanine-tyrosine branch is feedback inhibited by tyrosine and activated by tryptophan (CITS:[1943992]), and the first step in the tryptophan branch is feedback inhibited by tryptophan. The transcriptional activator GCN4 regulates most of the genes encoding for the aromatic amino acid biosynthetic enzymes. SOURCE: SGD pathways,


Meredith Braymer , Caroline Mrejen , Thomas Kelder , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Saccharomyces cerevisiae



Pathway Ontology

glycerophospholipid metabolic pathway


Label Type Compact URI Comment
glycerol Metabolite cas:56-81-5
Metabolite Metabolite kegg.compound:C03372
1,2 diacylglycerol Metabolite kegg.compound:C00641
L-serine Metabolite cas:56-45-1
pyrophosphate Metabolite cas:2466-09-3
phosphate Metabolite cas:14265-44-2
Glycerol-3-Phosphate Metabolite hmdb:HMDB0000126
CDP-choline Metabolite cas:987-78-0
Phosphate Metabolite pubchem.compound:1061
CTP Metabolite kegg.compound:C00063
L-1-phosphatidyl-ethanolamine Metabolite cas:2644-64-6
H2O Metabolite hmdb:HMDB0002111
phosphatidic acid Metabolite pubchem.compound:5287505
NADP Metabolite hmdb:HMDB0000217
CDP-1,2-Diacylglycerol Metabolite kegg.compound:C00269
lysophosphatidic acid Metabolite pubchem.compound:5497152
NADPH Metabolite hmdb:HMDB0000221
CPT1 GeneProduct sgd:S000005074
CRD1 GeneProduct sgd:S000002301
GPT2 GeneProduct ncbigene:853941
CHO2 GeneProduct sgd:S000003389
OPI3 GeneProduct sgd:S000003834
CHO1 GeneProduct sgd:S000000828
PSD2 GeneProduct sgd:S000003402
PGS1 GeneProduct sgd:S000000510
LPP1 GeneProduct ensembl:YDR503C
SLC1 GeneProduct sgd:S000002210
AYR1 GeneProduct sgd:S000001386
PAH1 GeneProduct ensembl:YMR165C
OPI3 GeneProduct sgd:S000003834
SCT1 GeneProduct ncbigene:852271
CDS1 GeneProduct sgd:S000000233
PSD1 GeneProduct sgd:S000005113