Hematopoietic stem cell differentiation (WP3174)
Bos taurus
Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature and NHLBI Progenitor Cell Biology Consortium (PCBC) collaborators.
Authors
Martina Summer-Kutmon and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
Interleukin mediated signaling pathwayCell Type Ontology
peripheral blood stem cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| NFATC2 | GeneProduct | ensembl:ENSBTAG00000018270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101096 |
| KCNH2 | GeneProduct | ensembl:ENSBTAG00000004078 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000055118 |
| IKZF1 | GeneProduct | ensembl:ENSBTAG00000014016 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185811 |
| LYL1 | GeneProduct | ensembl:ENSBTAG00000019329 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104903 |
| STAT5A | GeneProduct | ensembl:ENSBTAG00000009496 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126561 |
| MYB | GeneProduct | ensembl:ENSBTAG00000012074 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118513 |
| SPI1 | GeneProduct | ensembl:ENSBTAG00000021709 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000066336 |
| VAV1 | GeneProduct | ensembl:ENSBTAG00000039160 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141968 |
| CBFA2T3 | GeneProduct | ensembl:ENSBTAG00000010927 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129993 |
| KLF1 | GeneProduct | ensembl:ENSBTAG00000006083 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105610 |
| FOS | GeneProduct | ensembl:ENSBTAG00000004322 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345 |
| TRIM29 | GeneProduct | ensembl:ENSBTAG00000009419 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137699 |
| LMO2 | GeneProduct | ensembl:ENSBTAG00000006951 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135363 |
| NCKAP1L | GeneProduct | ensembl:ENSBTAG00000019686 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123338 |
| CSF3 | GeneProduct | ensembl:ENSBTAG00000021462 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108342 |
| IL5 | GeneProduct | ensembl:ENSBTAG00000031235 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113525 |
| CSF1 | GeneProduct | ensembl:ENSBTAG00000000283 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184371 |
| GATA1 | GeneProduct | ensembl:ENSBTAG00000003184 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102145 |
| KITLG | GeneProduct | ensembl:ENSBTAG00000017549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130 |
| EPO | GeneProduct | ensembl:ENSBTAG00000003430 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130427 |
| IL6 | GeneProduct | ensembl:ENSBTAG00000014921 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244 |
| IL1A | GeneProduct | ensembl:ENSBTAG00000010349 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115008 |
| CSF2 | GeneProduct | ensembl:ENSBTAG00000001570 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164400 |
| IL1B | GeneProduct | ensembl:ENSBTAG00000001321 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538 |
| KITLG | GeneProduct | ensembl:ENSBTAG00000017549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130 |
| CSF2 | GeneProduct | ensembl:ENSBTAG00000001570 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164400 |
| CSF2 | GeneProduct | ensembl:ENSBTAG00000001570 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164400 |
| CXCR4 | GeneProduct | ensembl:ENSBTAG00000001060 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121966 |
| MXI1 | GeneProduct | ensembl:ENSBTAG00000017263 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119950 |
| RIOK3 | GeneProduct | ensembl:ENSBTAG00000010042 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101782 |
| ACVR1B | GeneProduct | ensembl:ENSBTAG00000013555 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135503 |
| bta-mir-16a | GeneProduct | ensembl:ENSBTAG00000036389 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000208006 |
| GATA1 | GeneProduct | ensembl:ENSBTAG00000003184 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102145 |
| GATA1 | GeneProduct | ensembl:ENSBTAG00000003184 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102145 |
| GATA1 | GeneProduct | ensembl:ENSBTAG00000003184 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102145 |
| ABO | GeneProduct | ensembl:ENSBTAG00000012525 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175164 |
| ITGA2B | GeneProduct | ensembl:ENSBTAG00000008165 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000005961 |
| GP9 | GeneProduct | ensembl:ENSBTAG00000014666 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169704 |
| SPI1 | GeneProduct | ensembl:ENSBTAG00000021709 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000066336 |
| RUNX1 | GeneProduct | ensembl:ENSBTAG00000004742 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159216 |
| NOTCH1 | GeneProduct | ensembl:ENSBTAG00000022799 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148400 |
| ITGA2B | GeneProduct | ensembl:ENSBTAG00000008165 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000005961 |
| GATA2 | GeneProduct | ensembl:ENSBTAG00000019707 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179348 |
| NFE2 | GeneProduct | ensembl:ENSBTAG00000001562 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123405 |
| INTB3 | GeneProduct | ensembl:ENSBTAG00000009987 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690 |
| IL6 | GeneProduct | ensembl:ENSBTAG00000014921 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244 |
| KITLG | GeneProduct | ensembl:ENSBTAG00000017549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130 |
| CSF2 | GeneProduct | ensembl:ENSBTAG00000001570 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164400 |
| CSF3 | GeneProduct | ensembl:ENSBTAG00000021462 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108342 |
| IL6 | GeneProduct | ensembl:ENSBTAG00000014921 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244 |
| KITLG | GeneProduct | ensembl:ENSBTAG00000017549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130 |
| CSF2 | GeneProduct | ensembl:ENSBTAG00000001570 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164400 |
| CSF2 | GeneProduct | ensembl:ENSBTAG00000001570 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164400 |
| IL6 | GeneProduct | ensembl:ENSBTAG00000014921 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244 |
| KITLG | GeneProduct | ensembl:ENSBTAG00000017549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130 |
| CSF2 | GeneProduct | ensembl:ENSBTAG00000001570 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164400 |
References
- The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis. Slavov SN, Gimenes Teixeira HL, Rego EM. Braz J Med Biol Res. 2010 Jul;43(7):619–26. PubMed Europe PMC Scholia
- MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Zhang L, Sankaran VG, Lodish HF. Leukemia. 2012 Nov;26(11):2310–6. PubMed Europe PMC Scholia
- Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, et al. Cell. 2014 Apr 24;157(3):549–64. PubMed Europe PMC Scholia