Fatty acid biosynthesis (WP568)

Drosophila melanogaster

The production of fatty acids from acetyl-CoA and NADPH through the use of enzymes known as fatty acid synthases is referred to as fatty acid synthesis. This biological process occurs within the cytoplasm of cells. The majority of acetyl-CoA that is transformed into fatty acids originates from carbohydrates through the glycolytic pathway.


Kdahlquist , Chris Evelo , Christine Chichester , Egon Willighagen , Andra Waagmeester , Denise Slenter , Lauren J. Dupuis , Finterly Hu , Eric Weitz , and Alex Pico


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Drosophila melanogaster



Pathway Ontology

fatty acid biosynthetic pathway


Label Type Compact URI Comment
Butyryl-ACP Metabolite chebi:3247
Malonyl-CoA Metabolite hmdb:HMDB0001175
3-ketoacyl-CoA Metabolite chebi:57347
beta-hydroxybutyryl Metabolite pubchem.compound:644065
Pyruvate Metabolite chemspider:96901
Long-Chain fatty acid Metabolite chebi:15904
Acetyl-CoA Metabolite chemspider:392413
Palmitate Metabolite chemspider:440215
Acetoacetyl-ACP Metabolite chebi:2393
Malonyl-ACP Metabolite kegg.compound:C01209
Oxaloacetate Metabolite chemspider:2509917
Citrate Metabolite chemspider:29081
Fatty acyl CoA Metabolite chebi:37554
Acyl-CoA (n+2) Metabolite chebi:37554
Acetyl-ACP Metabolite kegg.compound:C03939
yip2 GeneProduct ncbigene:34313
AcCoAS GeneProduct ncbigene:40348
CG3523 GeneProduct ncbigene:33524
CG3523 GeneProduct ncbigene:33524
CG3523 GeneProduct ncbigene:33524
CG3523 GeneProduct ncbigene:33524
SCD GeneProduct ncbigene:252579
CG6543 GeneProduct ncbigene:36536
CG16935 GeneProduct ncbigene:36540
CG6984 GeneProduct ncbigene:36926
CG1516 GeneProduct ncbigene:36020
CG3523 GeneProduct ncbigene:33524
ATPCL GeneProduct ncbigene:36760
CG11198 GeneProduct ncbigene:35761
CG3961 GeneProduct ncbigene:40056
CG3523 GeneProduct ncbigene:33524
l(2)44DEa GeneProduct ncbigene:46068
CG3523 GeneProduct ncbigene:33524
CG9577 GeneProduct ncbigene:33016
CG3523 GeneProduct ncbigene:33524


  1. Purification and characterization of [acyl-carrier-protein] acetyltransferase from Escherichia coli. Lowe PN, Rhodes S. Biochem J. 1988 Mar 15;250(3):789–96. PubMed Europe PMC Scholia
  2. Fatty acid metabolism in Drosophila melanogaster: interaction between dietary fatty acids and de novo synthesis. Keith AD. Comp Biochem Physiol. 1967 Jun;21(3):587–600. PubMed Europe PMC Scholia
  3. Biosynthesis of medium chain fatty acids in Drosophila melanogaster. de Renobales M, Blomquist GJ. Arch Biochem Biophys. 1984 Feb 1;228(2):407–14. PubMed Europe PMC Scholia
  4. Drosophila melanogaster Acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system. Parvy JP, Napal L, Rubin T, Poidevin M, Perrin L, Wicker-Thomas C, et al. PLoS Genet. 2012;8(8):e1002925. PubMed Europe PMC Scholia