SARS coronavirus and innate immunity (WP4912)
Homo sapiens
SARS-CoV triggers the hosts innate immune system via the type I interferon system in dendritic cells and macrophages, which activate ISRE and IFN-b sentitive promoter elements.
Authors
Friederike Ehrhart , Egon Willighagen , Lauren J. Dupuis , and John Figueira HasbunActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
COVID-19Annotations
Pathway Ontology
type I interferon signaling pathwayDisease Ontology
viral infectious disease severe acute respiratory syndromeReferences
- Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. Spiegel M, Pichlmair A, Martínez-Sobrido L, Cros J, García-Sastre A, Haller O, et al. J Virol. 2005 Feb;79(4):2079–86. PubMed Europe PMC Scholia
- SARS coronavirus and innate immunity. Frieman M, Heise M, Baric R. Virus Res. 2008 Apr;133(1):101–12. PubMed Europe PMC Scholia