SARS coronavirus and innate immunity (WP4912)

Homo sapiens

SARS-CoV triggers the hosts innate immune system via the type I interferon system in dendritic cells and macrophages, which activate ISRE and IFN-b sentitive promoter elements.


Friederike Ehrhart , Egon Willighagen , Lauren J. Dupuis , John Figueira Hasbun , and Eric Weitz


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Homo sapiens




Disease Ontology

viral infectious disease severe acute respiratory syndrome Coronavirus infectious disease

Pathway Ontology

type I interferon signaling pathway


Label Type Compact URI Comment
IFNA1 GeneProduct ensembl:ENSG00000197919
IFNA2 GeneProduct ensembl:ENSG00000188379
IFNA4 GeneProduct ensembl:ENSG00000236637
IFNA5 GeneProduct ensembl:ENSG00000147873
IFNA6 GeneProduct ensembl:ENSG00000120235
IFNA7 GeneProduct ensembl:ENSG00000214042
IFNA8 GeneProduct ensembl:ENSG00000120242
IFNA10 GeneProduct ensembl:ENSG00000186803
IFNA13 GeneProduct ensembl:ENSG00000233816
IFNA14 GeneProduct ensembl:ENSG00000228083
IFNA16 GeneProduct ensembl:ENSG00000147885
IFNA17 GeneProduct ensembl:ENSG00000234829
IFNA21 GeneProduct ensembl:ENSG00000137080
JAK1 GeneProduct ensembl:ENSG00000162434
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
TBK1 GeneProduct ensembl:ENSG00000183735
IKBKE GeneProduct ensembl:ENSG00000263528 IKK-e
TLR3 GeneProduct ensembl:ENSG00000164342
IFNB1 GeneProduct ensembl:ENSG00000171855
IFNAR1 GeneProduct ncbigene:3454
TYK2 GeneProduct ensembl:ENSG00000105397
ACE2 GeneProduct ensembl:ENSG00000130234
IRF9 GeneProduct ensembl:ENSG00000213928
TRAF3 GeneProduct ensembl:ENSG00000131323
IFIH1 GeneProduct ensembl:ENSG00000115267 MDA5
IRF3 GeneProduct ensembl:ENSG00000126456
MAVS GeneProduct ensembl:ENSG00000088888
IFNAR2 GeneProduct ncbigene:3455
DDX58 GeneProduct ensembl:ENSG00000107201 RIG-I
TICAM1 GeneProduct ncbigene:148022 TRIF
S Protein uniprot:P0DTC2


  1. Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. Spiegel M, Pichlmair A, Martínez-Sobrido L, Cros J, García-Sastre A, Haller O, et al. J Virol. 2005 Feb;79(4):2079–86. PubMed Europe PMC Scholia
  2. SARS coronavirus and innate immunity. Frieman M, Heise M, Baric R. Virus Res. 2008 Apr;133(1):101–12. PubMed Europe PMC Scholia