SARS coronavirus and innate immunity (WP4912)

Homo sapiens

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SARS-CoV triggers the hosts innate immune system via the type I interferon system in dendritic cells and macrophages, which activate ISRE and IFN-b sentitive promoter elements.

Authors

Friederike Ehrhart , Egon Willighagen , Lauren J. Dupuis , John Figueira Hasbun , Eric Weitz , and Aishwarya Iyer

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

type I interferon signaling pathway

Disease Ontology

Coronavirus infectious disease severe acute respiratory syndrome viral infectious disease

Participants
Query Drugst.One

Label Type Compact URI Comment
IFNA21 GeneProduct ensembl:ENSG00000137080
IFNA10 GeneProduct ensembl:ENSG00000186803
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
IRF9 GeneProduct ensembl:ENSG00000213928
IKBKE GeneProduct ensembl:ENSG00000263528 IKK-e
TBK1 GeneProduct ensembl:ENSG00000183735
TRAF3 GeneProduct ensembl:ENSG00000131323
IFNA17 GeneProduct ensembl:ENSG00000234829
IFNA13 GeneProduct ensembl:ENSG00000233816
IFNA6 GeneProduct ensembl:ENSG00000120235
IFNA16 GeneProduct ensembl:ENSG00000147885
IFNAR2 GeneProduct ncbigene:3455
IFNA2 GeneProduct ensembl:ENSG00000188379
IFNA7 GeneProduct ensembl:ENSG00000214042
IFIH1 GeneProduct ensembl:ENSG00000115267 MDA5
TYK2 GeneProduct ensembl:ENSG00000105397
MAVS GeneProduct ensembl:ENSG00000088888
IFNA8 GeneProduct ensembl:ENSG00000120242
IFNB1 GeneProduct ensembl:ENSG00000171855
IFNA1 GeneProduct ensembl:ENSG00000197919
IRF3 GeneProduct ensembl:ENSG00000126456
IFNA14 GeneProduct ensembl:ENSG00000228083
IFNA4 GeneProduct ensembl:ENSG00000236637
IFNAR1 GeneProduct ncbigene:3454
TLR3 GeneProduct ensembl:ENSG00000164342
DDX58 GeneProduct ensembl:ENSG00000107201 RIG-I
ACE2 GeneProduct ensembl:ENSG00000130234
TICAM1 GeneProduct ncbigene:148022 TRIF
JAK1 GeneProduct ensembl:ENSG00000162434
IFNA5 GeneProduct ensembl:ENSG00000147873
S Protein uniprot:P0DTC2

References

  1. Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. Spiegel M, Pichlmair A, Martínez-Sobrido L, Cros J, García-Sastre A, Haller O, et al. J Virol. 2005 Feb;79(4):2079–86. PubMed Europe PMC Scholia
  2. SARS coronavirus and innate immunity. Frieman M, Heise M, Baric R. Virus Res. 2008 Apr;133(1):101–12. PubMed Europe PMC Scholia