Glycolysis and gluconeogenesis (WP1027)

Bos taurus

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids. Description adapted from [http://www.wikipedia.org Wikipedia].

Authors

Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

gluconeogenesis pathway glycolysis/gluconeogenesis pathway

Participants

Label Type Compact URI Comment
Malate Metabolite hmdb:HMDB0000744
2P-Glycerate Metabolite hmdb:HMDB0000362
Oxaloacetate Metabolite hmdb:HMDB0000223
1,3BP-Glycerate Metabolite hmdb:HMDB0001270
Acetyl-CoA Metabolite hmdb:HMDB0001206
3P-Glycerate Metabolite hmdb:HMDB0000807
Fructose-1,6BP Metabolite hmdb:HMDB0001058
Lactate Metabolite hmdb:HMDB0000190
Glucose Metabolite hmdb:HMDB0000122
Glyceraldehyde 3P Metabolite hmdb:HMDB0001112
Pyruvate Metabolite hmdb:HMDB0000243
Fructose 6P Metabolite hmdb:HMDB0000124
Aspartate Metabolite hmdb:HMDB0000191
Dihydroxyacetone-P Metabolite hmdb:HMDB0001473
P-enolpyruvate Metabolite hmdb:HMDB0000263
Glucose-6P Metabolite hmdb:HMDB0001401
TPI1 GeneProduct ensembl:ENSBTAG00000019782 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7167
PFKP GeneProduct ensembl:ENSBTAG00000002683 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5214
FBP1 GeneProduct ensembl:ENSBTAG00000009733 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2203
ALDOA GeneProduct ensembl:ENSBTAG00000012927 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:226
PKM2 GeneProduct ensembl:ENSBTAG00000001601 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5315
ALDOC GeneProduct ensembl:ENSBTAG00000013099 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:230
SLC2A2 GeneProduct ensembl:ENSBTAG00000005386 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6514
GOT1 GeneProduct ensembl:ENSBTAG00000011960 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2805
GAPDH GeneProduct ensembl:ENSBTAG00000018554 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111640
DLD GeneProduct ensembl:ENSBTAG00000001908 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1738
PC GeneProduct ensembl:ENSBTAG00000019700 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5091
PDHX GeneProduct ensembl:ENSBTAG00000018261 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8050
GPI GeneProduct ensembl:ENSBTAG00000006396 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2821
PFKM GeneProduct ensembl:ENSBTAG00000000286 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5213
GOT2 GeneProduct ensembl:ENSBTAG00000007172 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2806
PGK1 GeneProduct ensembl:ENSBTAG00000000894 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5230
GAPDHS GeneProduct ensembl:ENSBTAG00000015917 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26330
MDH1 GeneProduct ensembl:ENSBTAG00000019295 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4190
PKLR GeneProduct ensembl:ENSBTAG00000017056 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5313
SLC2A5 GeneProduct ensembl:ENSBTAG00000007302 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6518
PDHA1 GeneProduct ensembl:ENSBTAG00000019852 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5160
MDH2 GeneProduct ensembl:ENSBTAG00000009462 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4191
LDHA GeneProduct ensembl:ENSBTAG00000008683 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3939
HK1 GeneProduct ensembl:ENSBTAG00000012380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3098
PDHA2 GeneProduct ensembl:ENSBTAG00000026250 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5161
SLC2A1 GeneProduct ensembl:ENSBTAG00000009617 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6513
PGAM2 GeneProduct ensembl:ENSBTAG00000014547 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5224
DLAT GeneProduct ensembl:ENSBTAG00000038327 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1737
PFKL GeneProduct ensembl:ENSBTAG00000010658 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5211
ENO3 GeneProduct ensembl:ENSBTAG00000005534 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2027
ENO1 GeneProduct ensembl:ENSBTAG00000013411 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2023
LDHC GeneProduct ensembl:ENSBTAG00000002488 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3948
HK3 GeneProduct ensembl:ENSBTAG00000014898 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3101
LDHB GeneProduct ensembl:ENSBTAG00000019603 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3945
MPC2 GeneProduct ensembl:ENSBTAG00000020968 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25874
MPC1 GeneProduct ensembl:ENSBTAG00000027879 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51660
ENO2 GeneProduct ensembl:ENSBTAG00000011274 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2026
G6PC GeneProduct ensembl:ENSBTAG00000010184 Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2538
HK2 GeneProduct ensembl:ENSBTAG00000013108 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3099
PCK1 GeneProduct ensembl:ENSBTAG00000001936 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5105
PDHB GeneProduct ensembl:ENSBTAG00000021724 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5162
SLC2A4 GeneProduct ensembl:ENSBTAG00000009190 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6517
FBP2 GeneProduct ensembl:ENSBTAG00000019554 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8789
SLC2A3 GeneProduct ensembl:ENSBTAG00000004556 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6515
GCK GeneProduct ensembl:ENSBTAG00000032288 Gck is mainly active in liver
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2645
ALDOB GeneProduct ensembl:ENSBTAG00000015358 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:229

References

  1. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, et al. Science. 2012 Jul 6;337(6090):96–100. PubMed Europe PMC Scholia