Glycolysis and gluconeogenesis (WP1027)
Bos taurus
Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as pyruvate, lactate, glycerol, glucogenic amino acids, and fatty acids. Description adapted from [http://www.wikipedia.org Wikipedia].
Authors
Martina Summer-Kutmon , Egon Willighagen , and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
gluconeogenesis pathway glycolysis/gluconeogenesis pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Malate | Metabolite | hmdb:HMDB0000744 | |
| 2P-Glycerate | Metabolite | hmdb:HMDB0000362 | |
| Oxaloacetate | Metabolite | hmdb:HMDB0000223 | |
| 1,3BP-Glycerate | Metabolite | hmdb:HMDB0001270 | |
| Oxaloacetate | Metabolite | hmdb:HMDB0000223 | |
| Acetyl-CoA | Metabolite | hmdb:HMDB0001206 | |
| 3P-Glycerate | Metabolite | hmdb:HMDB0000807 | |
| Fructose-1,6BP | Metabolite | hmdb:HMDB0001058 | |
| Lactate | Metabolite | hmdb:HMDB0000190 | |
| Glucose | Metabolite | hmdb:HMDB0000122 | |
| Glyceraldehyde 3P | Metabolite | hmdb:HMDB0001112 | |
| Pyruvate | Metabolite | hmdb:HMDB0000243 | |
| Pyruvate | Metabolite | hmdb:HMDB0000243 | |
| Fructose 6P | Metabolite | hmdb:HMDB0000124 | |
| Malate | Metabolite | hmdb:HMDB0000744 | |
| Glucose | Metabolite | hmdb:HMDB0000122 | |
| Aspartate | Metabolite | hmdb:HMDB0000191 | |
| Dihydroxyacetone-P | Metabolite | hmdb:HMDB0001473 | |
| P-enolpyruvate | Metabolite | hmdb:HMDB0000263 | |
| Aspartate | Metabolite | hmdb:HMDB0000191 | |
| Glucose-6P | Metabolite | hmdb:HMDB0001401 | |
| TPI1 | GeneProduct | ensembl:ENSBTAG00000019782 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7167 |
| PFKP | GeneProduct | ensembl:ENSBTAG00000002683 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5214 |
| FBP1 | GeneProduct | ensembl:ENSBTAG00000009733 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2203 |
| ALDOA | GeneProduct | ensembl:ENSBTAG00000012927 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:226 |
| PKM2 | GeneProduct | ensembl:ENSBTAG00000001601 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5315 |
| ALDOC | GeneProduct | ensembl:ENSBTAG00000013099 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:230 |
| SLC2A2 | GeneProduct | ensembl:ENSBTAG00000005386 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6514 |
| GOT1 | GeneProduct | ensembl:ENSBTAG00000011960 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2805 |
| GAPDH | GeneProduct | ensembl:ENSBTAG00000018554 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111640 |
| DLD | GeneProduct | ensembl:ENSBTAG00000001908 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1738 |
| PC | GeneProduct | ensembl:ENSBTAG00000019700 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5091 |
| PDHX | GeneProduct | ensembl:ENSBTAG00000018261 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8050 |
| GPI | GeneProduct | ensembl:ENSBTAG00000006396 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2821 |
| PFKM | GeneProduct | ensembl:ENSBTAG00000000286 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5213 |
| GOT2 | GeneProduct | ensembl:ENSBTAG00000007172 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2806 |
| PGK1 | GeneProduct | ensembl:ENSBTAG00000000894 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5230 |
| GAPDHS | GeneProduct | ensembl:ENSBTAG00000015917 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26330 |
| MDH1 | GeneProduct | ensembl:ENSBTAG00000019295 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4190 |
| PKLR | GeneProduct | ensembl:ENSBTAG00000017056 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5313 |
| SLC2A5 | GeneProduct | ensembl:ENSBTAG00000007302 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6518 |
| PDHA1 | GeneProduct | ensembl:ENSBTAG00000019852 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5160 |
| MDH2 | GeneProduct | ensembl:ENSBTAG00000009462 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4191 |
| LDHA | GeneProduct | ensembl:ENSBTAG00000008683 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3939 |
| HK1 | GeneProduct | ensembl:ENSBTAG00000012380 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3098 |
| PDHA2 | GeneProduct | ensembl:ENSBTAG00000026250 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5161 |
| SLC2A1 | GeneProduct | ensembl:ENSBTAG00000009617 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6513 |
| PGAM2 | GeneProduct | ensembl:ENSBTAG00000014547 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5224 |
| DLAT | GeneProduct | ensembl:ENSBTAG00000038327 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1737 |
| PFKL | GeneProduct | ensembl:ENSBTAG00000010658 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5211 |
| ENO3 | GeneProduct | ensembl:ENSBTAG00000005534 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2027 |
| ENO1 | GeneProduct | ensembl:ENSBTAG00000013411 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2023 |
| LDHC | GeneProduct | ensembl:ENSBTAG00000002488 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3948 |
| HK3 | GeneProduct | ensembl:ENSBTAG00000014898 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3101 |
| LDHB | GeneProduct | ensembl:ENSBTAG00000019603 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3945 |
| MPC2 | GeneProduct | ensembl:ENSBTAG00000020968 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25874 |
| MPC1 | GeneProduct | ensembl:ENSBTAG00000027879 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51660 |
| ENO2 | GeneProduct | ensembl:ENSBTAG00000011274 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2026 |
| G6PC | GeneProduct | ensembl:ENSBTAG00000010184 | Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathwayHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2538 |
| HK2 | GeneProduct | ensembl:ENSBTAG00000013108 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3099 |
| PCK1 | GeneProduct | ensembl:ENSBTAG00000001936 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5105 |
| PDHB | GeneProduct | ensembl:ENSBTAG00000021724 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5162 |
| SLC2A4 | GeneProduct | ensembl:ENSBTAG00000009190 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6517 |
| FBP2 | GeneProduct | ensembl:ENSBTAG00000019554 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8789 |
| SLC2A3 | GeneProduct | ensembl:ENSBTAG00000004556 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6515 |
| GCK | GeneProduct | ensembl:ENSBTAG00000032288 | Gck is mainly active in liverHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2645 |
| PKM2 | GeneProduct | ensembl:ENSBTAG00000001601 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5315 |
| ALDOB | GeneProduct | ensembl:ENSBTAG00000015358 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:229 |
References
- A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, et al. Science. 2012 Jul 6;337(6090):96–100. PubMed Europe PMC Scholia