Glycine metabolism (WP3142)

Bos taurus

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Glycine is degraded through three pathways: The glycine cleavage system (GCS); by serine hydroxymethyltransferase, and conversion to glyoxylate. In animals, the main pathway is GCS, which is essentially the reverse of the glycine synthase pathway. Degradation of by serine hydroxymethyltransferase happens in two steps. First, glycine is converted to serine by serine hydroxymethyl transferase. Serine is then converted to pyruvate by serine dehydratase. Glycine can also be converted to glyoxylate by D-amino acid oxidase. Glyoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate. Description adapted from Wikipedia.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Martina Summer-Kutmon , Eric Weitz , and Kristina Hanspers

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

glycine metabolic pathway

Participants

Label Type Compact URI Comment
Serine Metabolite chemspider:597
Pyruvate Metabolite chemspider:96901
Glutamate Metabolite chemspider:4302384
MTHF Metabolite chemspider:97272
Glycine Metabolite hmdb:HMDB0000123
Purines Metabolite chebi:26401
SHMT1 GeneProduct ensembl:ENSBTAG00000017094 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6470
SHMT2 GeneProduct ensembl:ENSBTAG00000031500 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6472
MTHFR GeneProduct ensembl:ENSBTAG00000020698 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177000

References