Target of rapamycin signaling (WP1471)
Homo sapiens
TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response. TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1471 CPTAC Assay Portal]
Authors
Pieter Giesbertz , Alex Pico , Kristina Hanspers , Egon Willighagen , Jlw9 , Marianthi Kalafati , Martina Summer-Kutmon , and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
- Machine learning and bioinformatics to identify 8 autophagy-related biomarkers and construct gene regulatory networks in dilated cardiomyopathy (2022).
- Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesis (2021).
- Transcriptome Alterations In X-Irradiated Human Gingiva Fibroblasts (2016).
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Homo sapiensCommunities
CPTAC PancCanNetAnnotations
Pathway Ontology
insulin signaling pathway mTOR signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayReferences
- TOR signaling in growth and metabolism. Wullschleger S, Loewith R, Hall MN. Cell. 2006 Feb 10;124(3):471–84. PubMed Europe PMC Scholia
- Complexity of the TOR signaling network. Inoki K, Guan KL. Trends Cell Biol. 2006 Apr;16(4):206–12. PubMed Europe PMC Scholia
- Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Corradetti MN, Guan KL. Oncogene. 2006 Oct 16;25(48):6347–60. PubMed Europe PMC Scholia
- Expanding mTOR signaling. Yang Q, Guan KL. Cell Res. 2007 Aug;17(8):666–81. PubMed Europe PMC Scholia
- Rag proteins regulate amino-acid-induced mTORC1 signalling. Sancak Y, Sabatini DM. Biochem Soc Trans. 2009 Feb;37(Pt 1):289–90. PubMed Europe PMC Scholia
- mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells. Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, et al. Cell Rep. 2014 Oct 23;9(2):646–60. PubMed Europe PMC Scholia