Target of rapamycin signaling (WP1471)
TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response. TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1471 CPTAC Assay Portal]
AuthorsPieter Giesbertz , Alex Pico , Kristina Hanspers , Egon Willighagen , Jlw9 , Marianthi Kalafati , Martina Summer-Kutmon , and Eric Weitz
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- Machine learning and bioinformatics to identify 8 autophagy-related biomarkers and construct gene regulatory networks in dilated cardiomyopathy (2022).
- Transcriptomic changes in peripheral blood mononuclear cells with weight loss: systematic literature review and primary data synthesis (2021).
- Transcriptome Alterations In X-Irradiated Human Gingiva Fibroblasts (2016).
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Pathway Ontologyinsulin signaling pathway mTOR signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway
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