Nicotine activity on dopaminergic neurons (WP3179)
Bos taurus
Nicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body, it is distributed quickly through the bloodstream, and it can cross the blood-brain barrier to enter the central nervous system (CNS). It binds to two main types of nicotinic acetylcholine receptors: the ganglion type and the CNS type. In dopaminergic neurons in the CNS, nicotine binds to the CNS-type nicotinic acetylcholine receptors.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Martina Summer-Kutmon , Eric Weitz , Egon Willighagen , and Aishwarya IyerActivity
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Organisms
Bos taurusCommunities
Annotations
Cell Type Ontology
dopaminergic neuronPathway Ontology
nicotine drug pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ca²⁺ | Metabolite | hmdb:HMDB0000464 | |
| Tyrosine | Metabolite | hmdb:HMDB0000158 | |
| K⁺ | Metabolite | hmdb:HMDB0000586 | |
| Dopamine | Metabolite | hmdb:HMDB0000073 | |
| Na⁺ | Metabolite | hmdb:HMDB0000588 | |
| cAMP | Metabolite | hmdb:HMDB0000058 | |
| DOPA | Metabolite | hmdb:HMDB0000181 | |
| Nicotine | Metabolite | hmdb:HMDB0001934 | |
| ATP | Metabolite | hmdb:HMDB0000538 | |
| CDK5 | GeneProduct | ensembl:ENSBTAG00000007766 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1020 |
| TH | GeneProduct | ensembl:ENSBTAG00000026768 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7054 |
| DRD3 | GeneProduct | ensembl:ENSBTAG00000002132 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1814 |
| GNB1 | GeneProduct | ensembl:ENSBTAG00000000215 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782 |
| GNAI1 | GeneProduct | ensembl:ENSBTAG00000002714 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770 |
| DRD4 | GeneProduct | ensembl:ENSBTAG00000051042 | |
| PPP1R1B | GeneProduct | ensembl:ENSBTAG00000006035 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84152 |
| CHRNA6 | GeneProduct | ensembl:ENSBTAG00000014056 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8973 |
| CHRNB2 | GeneProduct | ensembl:ENSBTAG00000007517 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1141 |
| SLC18A2 | GeneProduct | ensembl:ENSBTAG00000004739 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6571 |
| GNG2 | GeneProduct | ensembl:ENSBTAG00000003043 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54331 |
| DRD2 | GeneProduct | ensembl:ENSBTAG00000010860 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1813 |
| CHRNA4 | GeneProduct | ensembl:ENSBTAG00000017198 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1137 |
| DDC | GeneProduct | ensembl:ENSBTAG00000020869 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1644 |
| CHRNA3 | GeneProduct | ensembl:ENSBTAG00000003130 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1136 |
| PPP1CA | GeneProduct | ensembl:ENSBTAG00000040418 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5499 |
| CHRNA5 | GeneProduct | ensembl:ENSBTAG00000013657 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1138 |
| ADCY2 | GeneProduct | ensembl:ENSBTAG00000019210 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108 |
| PRKACA | GeneProduct | ensembl:ENSBTAG00000006642 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566 |
| KCNK9 | GeneProduct | ensembl:ENSBTAG00000047488 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51305 |
| KCNK3 | GeneProduct | ensembl:ENSBTAG00000018193 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3777 |
References
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- The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine. Eiden LE, Schäfer MKH, Weihe E, Schütz B. Pflugers Arch. 2004 Feb;447(5):636–40. PubMed Europe PMC Scholia
- A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles. Cartier EA, Parra LA, Baust TB, Quiroz M, Salazar G, Faundez V, et al. J Biol Chem. 2010 Jan 15;285(3):1957–66. PubMed Europe PMC Scholia