Focal adhesion: PI3K-Akt-mTOR signaling pathway (WP2841)

Mus musculus

Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Source: KEGG


Zhuohui Gan , Kristina Hanspers , Egon Willighagen , Jonathan Mélius , Martina Summer-Kutmon , Denise Slenter , Marvin Martens , and Eric Weitz


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Mus musculus



Pathway Ontology

signaling pathway cell adhesion signaling pathway mTOR signaling pathway phosphatidylinositol 3-kinase signaling pathway


Label Type Compact URI Comment
NO Metabolite chebi:29120
Insulin Metabolite chebi:5931
Col4a1 GeneProduct ncbigene:12826
Tsc2 GeneProduct ncbigene:22084
Col5a3 GeneProduct ncbigene:53867
Thbs4 GeneProduct ncbigene:21828
Prlr GeneProduct ncbigene:19116
Sos1 GeneProduct ncbigene:20662 SOS1; son of sevenless homolog 1 (Drosophila)
Col5a1 GeneProduct ncbigene:12831
Itgb6 GeneProduct ncbigene:16420
Pelo GeneProduct ncbigene:105083
Jak3 GeneProduct ncbigene:16453 CAV3; caveolin 3
Il2rg GeneProduct ncbigene:16186
Itga11 GeneProduct ncbigene:319480
Col11a2 GeneProduct ncbigene:12815
Lamb3 GeneProduct ncbigene:16780
Grb2 GeneProduct ncbigene:14784 GRB2; growth factor receptor-bound protein 2
Tnn GeneProduct ncbigene:329278
Stk11 GeneProduct ncbigene:20869
Gh GeneProduct ncbigene:14599
Il3ra GeneProduct ncbigene:16188
Epor GeneProduct ncbigene:13857
Itga7 GeneProduct ncbigene:16404
Itgam GeneProduct ncbigene:16409
Col1a2 GeneProduct ncbigene:12843
Pik3ip1 GeneProduct ncbigene:216505
Ibsp GeneProduct ncbigene:15891
Col5a2 GeneProduct ncbigene:12832
Osmr GeneProduct ncbigene:18414
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Thbs3 GeneProduct ncbigene:21827
Itga2 GeneProduct ncbigene:16398
Lama2 GeneProduct ncbigene:16773
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Csf3 GeneProduct ncbigene:12985
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Lama4 GeneProduct ncbigene:16775
Itgb8 GeneProduct ncbigene:320910
Itgad GeneProduct ncbigene:381924
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Lama5 GeneProduct ncbigene:16776
Ptk2 GeneProduct ncbigene:14083 DOCK1; dedicator of cyto-kinesis
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Tnxb GeneProduct ncbigene:81877
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Fn1 GeneProduct ncbigene:14268
Ddit4 GeneProduct ncbigene:74747
Col11a1 GeneProduct ncbigene:12814
Itga4 GeneProduct ncbigene:16401
Jak2 GeneProduct ncbigene:16452 CAV2; caveolin 2
Jak1 GeneProduct ncbigene:16451 CAV1; caveolin 1 caveolae protein 22kD
Vtn GeneProduct ncbigene:22370
Ifna1 GeneProduct ncbigene:15962
Ifna11 GeneProduct ncbigene:15964
Akt1 GeneProduct ncbigene:11651
Pik3cb GeneProduct ncbigene:74769
Pik3cd GeneProduct ncbigene:18707
Ghr GeneProduct ncbigene:14600
Il6ra GeneProduct ncbigene:16194
Comp GeneProduct ncbigene:12845
Lamc1 GeneProduct ncbigene:226519
Lamb2 GeneProduct ncbigene:16779
Il2rb GeneProduct ncbigene:16185
Pik3ca GeneProduct ncbigene:18706
Lama3 GeneProduct ensembl:ENSMUSG00000024421
Il2ra GeneProduct ncbigene:16184
Pten GeneProduct ncbigene:19211
Lamb1-1 GeneProduct ncbigene:16777
Reln GeneProduct ncbigene:19699
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Tsc1 GeneProduct ncbigene:64930
Itgb1 GeneProduct ncbigene:16412
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Itgae GeneProduct ncbigene:16407
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Tnr GeneProduct ncbigene:21960
Pik3r5 GeneProduct ncbigene:320207
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Fgf GeneProduct ncbigene:14164
Fgf11 GeneProduct ncbigene:14166
Fgf10 GeneProduct ncbigene:14165
Efna2 GeneProduct ncbigene:13637
Egf GeneProduct ncbigene:13645
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Fgf13 GeneProduct ncbigene:14168
Fgf15 GeneProduct ncbigene:14170
Fgf17 GeneProduct ncbigene:14171
Fgf18 GeneProduct ncbigene:14172
Fgf2 GeneProduct ncbigene:14173
Fgf3 GeneProduct ncbigene:14174
Fgf4 GeneProduct ncbigene:14175
Fgf6 GeneProduct ncbigene:14177
Fgf7 GeneProduct ncbigene:14178
Fgf8 GeneProduct ncbigene:14179
Fgf9 GeneProduct ncbigene:14180
Figf GeneProduct ncbigene:14205
Hgf GeneProduct ncbigene:15234
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Ins1 GeneProduct ncbigene:16333
Ins2 GeneProduct ncbigene:16334
Kitl GeneProduct ncbigene:17311
Kik1b4 GeneProduct ncbigene:18084
Kik1b4 GeneProduct ncbigene:18084
Vegfc GeneProduct ncbigene:22341
Vegfb GeneProduct ncbigene:22340
Pdgfb GeneProduct ncbigene:18591
Pgf GeneProduct ncbigene:18654
Pdgfa GeneProduct ncbigene:18590
Ngf GeneProduct ncbigene:18049
Pdgfc GeneProduct ncbigene:54635
Fgf21 GeneProduct ncbigene:56636
Fgf23 GeneProduct ncbigene:54654
Fgf22 GeneProduct ncbigene:67112
Pdgfd GeneProduct ncbigene:71785
Fgf20 GeneProduct ncbigene:80857
Fgf16 GeneProduct ncbigene:80903
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Kdr GeneProduct ncbigene:16542
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Kit GeneProduct ncbigene:16590
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Egfr GeneProduct ncbigene:13649
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Flt4 GeneProduct ncbigene:14257
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Met GeneProduct ncbigene:17295
Pdgfra GeneProduct ncbigene:18595
Pdgfrb GeneProduct ncbigene:18596
Tek GeneProduct ncbigene:21687
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Ifna6 GeneProduct ncbigene:15969
Ifna7 GeneProduct ncbigene:15970
Ifna9 GeneProduct ncbigene:15972
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Ifnb1 GeneProduct ncbigene:15977
Il2 GeneProduct ncbigene:16183
Osm GeneProduct ncbigene:18413
Prl GeneProduct ncbigene:19109
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Lpar1 GeneProduct ncbigene:14745
F2r GeneProduct ncbigene:14062
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Lpar2 GeneProduct ncbigene:53978
Lpar3 GeneProduct ncbigene:65086
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Lpar4 GeneProduct ncbigene:78134
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Gnb1 GeneProduct ncbigene:14688
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Gng12 GeneProduct ncbigene:14701
Gnb3 GeneProduct ncbigene:14695
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Gng3 GeneProduct ncbigene:14704
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Gng13 GeneProduct ncbigene:64337
Gng11 GeneProduct ncbigene:66066
Pik3cg GeneProduct ncbigene:30955
Nras GeneProduct ncbigene:18176 SOS1; son of sevenless homolog 1 (Drosophila)
Kras GeneProduct ncbigene:16653 SOS1; son of sevenless homolog 1 (Drosophila)
Hras GeneProduct ncbigene:15461 SOS1; son of sevenless homolog 1 (Drosophila)
Strada GeneProduct ncbigene:72149
Cab39 GeneProduct ncbigene:12283
Cab39l GeneProduct ncbigene:69008
Prkaa GeneProduct ncbigene:105787
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Rheb GeneProduct ncbigene:19744
Mtor GeneProduct ncbigene:56717
Rptor GeneProduct ncbigene:74370
Hif1a GeneProduct ncbigene:15251
Ulk1 GeneProduct ncbigene:22241
Crtc2 GeneProduct ncbigene:74343
Cdc37 GeneProduct ncbigene:12539
Hsp90ab1 GeneProduct ncbigene:15516
Phllp1 GeneProduct ncbigene:98432
Tcl1 GeneProduct ncbigene:21432
Pdk1 GeneProduct ncbigene:18607
Gm2436 GeneProduct ncbigene:100039815
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Ppp2r2c GeneProduct ncbigene:269643
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ppp2r5a GeneProduct ncbigene:226849
Ppp2r3c GeneProduct ncbigene:59032
Hsp90aa1 GeneProduct ncbigene:15519
Hsp90b1 GeneProduct ncbigene:22027
Phlpp2 GeneProduct ncbigene:244650
Mtcp1 GeneProduct ncbigene:17763
Tcl1b1 GeneProduct ncbigene:27379
Tcl1b4 GeneProduct ncbigene:27380
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Mapk2k2 GeneProduct ncbigene:26396 SOS1; son of sevenless homolog 1 (Drosophila)
Map2k1 GeneProduct ncbigene:26395 SOS1; son of sevenless homolog 1 (Drosophila)
Mapk1 GeneProduct ncbigene:26413 SOS1; son of sevenless homolog 1 (Drosophila)
Mapk3 GeneProduct ncbigene:26417 SOS1; son of sevenless homolog 1 (Drosophila)
Gsk3b GeneProduct ncbigene:56637 SOS1; son of sevenless homolog 1 (Drosophila)
Foxo3 GeneProduct ncbigene:56484 SOS1; son of sevenless homolog 1 (Drosophila)
Foxo1 GeneProduct ncbigene:56458 SOS1; son of sevenless homolog 1 (Drosophila)
Ikbkb GeneProduct ncbigene:16150 SOS1; son of sevenless homolog 1 (Drosophila)
Bad GeneProduct ncbigene:12015 SOS1; son of sevenless homolog 1 (Drosophila)
Casp9 GeneProduct ncbigene:12371 SOS1; son of sevenless homolog 1 (Drosophila)
Mdm2 GeneProduct ncbigene:17246 SOS1; son of sevenless homolog 1 (Drosophila)
Ikbkg GeneProduct ncbigene:16151 SOS1; son of sevenless homolog 1 (Drosophila)
Cdkn1b GeneProduct ncbigene:12576 SOS1; son of sevenless homolog 1 (Drosophila)
Cdkn1a GeneProduct ncbigene:12575 SOS1; son of sevenless homolog 1 (Drosophila)
Atf2 GeneProduct ncbigene:11909
Creb3 GeneProduct ncbigene:12913
Creb1 GeneProduct ncbigene:12912
Atf4 GeneProduct ncbigene:11911
Creb3l2 GeneProduct ncbigene:208647
Creb3l3 GeneProduct ncbigene:208677
Atf6b GeneProduct ncbigene:12915
Creb3l1 GeneProduct ncbigene:26427
Creb3l4 GeneProduct ncbigene:78284
Creb5 GeneProduct ncbigene:231991
Nos3 GeneProduct ncbigene:18127 SOS1; son of sevenless homolog 1 (Drosophila)
Tbc1d1 GeneProduct ncbigene:57915
Rab8a GeneProduct ncbigene:17274
Rab2a GeneProduct ncbigene:59021
Rab10 GeneProduct ncbigene:19325
Rab11b GeneProduct ncbigene:19326
Rab14 GeneProduct ncbigene:68365
Slc2a4 GeneProduct ncbigene:20528
Slc2a1 GeneProduct ncbigene:20525
Slc2a3 GeneProduct ncbigene:20527
Slc2a2 GeneProduct ncbigene:20526
Ppargc1a GeneProduct ncbigene:19017
Gys1 GeneProduct ncbigene:14936
Gys2 GeneProduct ncbigene:232493
Pfkfb2 GeneProduct ncbigene:18640
Pfkfb1 GeneProduct ncbigene:18639
Pfkfb3 GeneProduct ncbigene:170768
Pfkfb4 GeneProduct ncbigene:270198
Lipe GeneProduct ncbigene:16890
Srebf1 GeneProduct ncbigene:20787
Hmgcr GeneProduct ncbigene:15375
Acaca GeneProduct ncbigene:107476
Elavl1 GeneProduct ncbigene:15568
Nos1 GeneProduct ncbigene:18125 SOS1; son of sevenless homolog 1 (Drosophila)
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Hif2a GeneProduct ncbigene:13819
Hif3a GeneProduct ncbigene:53417
Rps6kb2 GeneProduct ncbigene:58988
Eif4ebp1 GeneProduct ncbigene:13685
Eif4b GeneProduct ncbigene:75705
Rps6kb1 GeneProduct ncbigene:72508
Rps6 GeneProduct ncbigene:20104
Eif4e GeneProduct ncbigene:13684
Eif4e2 GeneProduct ncbigene:26987
Eif4e1b GeneProduct ncbigene:218268
Pik3c2b GeneProduct ncbigene:240752
Pik3c2a GeneProduct ncbigene:18704
Pik3c2g GeneProduct ncbigene:18705
Irs1 GeneProduct ncbigene:16367
Irs4 GeneProduct ncbigene:16370
Irs3 GeneProduct ncbigene:16369
Irs2 GeneProduct ncbigene:384783
Insr GeneProduct ncbigene:13677 GRB2; growth factor receptor-bound protein 2
Ins1 GeneProduct ncbigene:13633 GRB2; growth factor receptor-bound protein 2
Ins2 GeneProduct ncbigene:13634 GRB2; growth factor receptor-bound protein 2


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