Myometrial relaxation and contraction pathways (WP3276)

Bos taurus

This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial muscle cells or act upon the myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gestation. These signaling events act to suppress coordinated contractions to prevent the early onset of labor at term, largely via activation of the adenylyl-cyclase thrhough G-protein coupled receptors. On the right side of this pathway are signaling componets involved in the activation of uterine contractions at labor, in particular, activation of calcium mobilization via Oxytocin mediated binding to the Oxytocin G-protein coupled receptor. Additional genes implicated in this pathway, based on microarray expression profiling of gestation, term and postpartum of term mice are also included (e.g., Guca2b, Rdc1, Edg2) have also been included. For a detailed description of this pathway see: http://genomebiology.com/2005/6/2/R12.

Authors

Martina Summer-Kutmon , Egon Willighagen , Eric Weitz , and Alex Pico

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

signaling pathway

Cell Type Ontology

smooth muscle cell

Participants

Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
Cyclic AMP Metabolite hmdb:HMDB0000058
ADP Metabolite cas:58-64-0
Cyclic GMP Metabolite hmdb:HMDB0001314
RAMP1 GeneProduct ensembl:ENSBTAG00000011534 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10267
IGFBP6 GeneProduct ensembl:ENSBTAG00000021467 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3489
GNG13 GeneProduct ensembl:ENSBTAG00000033526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51764
RGS11 GeneProduct ensembl:ENSBTAG00000016574 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8786
PRKCZ GeneProduct ensembl:ENSBTAG00000014119 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
ADCY5 GeneProduct ensembl:ENSBTAG00000018777 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:111
RYR1 GeneProduct ensembl:ENSBTAG00000006999 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6261
ATP2A3 GeneProduct ensembl:ENSBTAG00000014806 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:489
ATF4 GeneProduct ensembl:ENSBTAG00000017462 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:468
PRKAR2B GeneProduct ensembl:ENSBTAG00000014958 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5577
PRKCG GeneProduct ensembl:ENSBTAG00000013550 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582
ADCY2 GeneProduct ensembl:ENSBTAG00000019210 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:108
PRKCE GeneProduct ensembl:ENSBTAG00000020614 This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581
IGFBP5 GeneProduct ensembl:ENSBTAG00000007062 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3488
GRK4 GeneProduct ensembl:ENSBTAG00000001505 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2868
GNB3 GeneProduct ensembl:ENSBTAG00000016043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2784
GNG3 GeneProduct ensembl:ENSBTAG00000002508 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2785
PKIB GeneProduct ensembl:ENSBTAG00000004394 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5570
FOS GeneProduct ensembl:ENSBTAG00000004322 PMID: 10218980 PMID: 7628395 [
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
GRK5 GeneProduct ensembl:ENSBTAG00000007981 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2869
OXTR GeneProduct ensembl:ENSBTAG00000019772 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5021
MYLK2 GeneProduct ensembl:ENSBTAG00000014930 KML2 MOUSE
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85366
GNG12 GeneProduct ensembl:ENSBTAG00000035697 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55970
RGS2 GeneProduct ensembl:ENSBTAG00000034366 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5997
GNG2 GeneProduct ensembl:ENSBTAG00000003043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54331
RGS6 GeneProduct ensembl:ENSBTAG00000014189 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9628
JUN GeneProduct ensembl:ENSBTAG00000004037 PMID: 10218980
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
ADCY3 GeneProduct ensembl:ENSBTAG00000018705 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:109
GNG7 GeneProduct ensembl:ENSBTAG00000007644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2788
PRKACB GeneProduct ensembl:ENSBTAG00000011953 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5567
ATF6B GeneProduct ensembl:ENSBTAG00000008794 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1388
ACTA2 GeneProduct ensembl:ENSBTAG00000014614 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:59
RAMP2 GeneProduct ensembl:ENSBTAG00000019903 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10266
GPR182 GeneProduct ensembl:ENSBTAG00000039157 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11318
CT GeneProduct ensembl:ENSBTAG00000047380 CRF HUMAN PMID: 11854458
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:796
ADCY8 GeneProduct ensembl:ENSBTAG00000014600 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114
ADCY1 GeneProduct ensembl:ENSBTAG00000009520 CYA1 HUMAN
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:107
ARRB2 GeneProduct ensembl:ENSBTAG00000035587 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:409
ATF1 GeneProduct ensembl:ENSBTAG00000018131 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:466
NOS1 GeneProduct ensembl:ENSBTAG00000002023 PMID: 11854458
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842
RGS17 GeneProduct ensembl:ENSBTAG00000009277 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26575
PRKCH GeneProduct ensembl:ENSBTAG00000003276 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583
RYR2 GeneProduct ensembl:ENSBTAG00000022886 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6262
RGS18 GeneProduct ensembl:ENSBTAG00000013064 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64407
YWHAB GeneProduct ensembl:ENSBTAG00000016846 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7529
IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569
GRK6 GeneProduct ensembl:ENSBTAG00000043994 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2870
CRCP GeneProduct ensembl:ENSBTAG00000037489 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27297
RXFP1 GeneProduct ensembl:ENSBTAG00000010306 PMID: 11809971
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:59350
CNN1 GeneProduct ensembl:ENSBTAG00000011207 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1264
YWHAH GeneProduct ensembl:ENSBTAG00000011631 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7533
CAMK2G GeneProduct ensembl:ENSBTAG00000012667 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:818
RGS7 GeneProduct ensembl:ENSBTAG00000005410 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6000
MYL4 GeneProduct ensembl:ENSBTAG00000021916 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4635
RGS1 GeneProduct ensembl:ENSBTAG00000021672 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5996
PRKCB GeneProduct ensembl:ENSBTAG00000020921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
LPAR1 GeneProduct ensembl:ENSBTAG00000009654 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1902
RAMP3 GeneProduct ensembl:ENSBTAG00000020704 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10268
CAMK2D GeneProduct ensembl:ENSBTAG00000014463 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:817
PRKCQ GeneProduct ensembl:ENSBTAG00000010664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588
NOS3 GeneProduct ensembl:ENSBTAG00000017680 PMID: 11854458
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4846
CALD1 GeneProduct ensembl:ENSBTAG00000013953 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:800
GSTO1 GeneProduct ensembl:ENSBTAG00000003989 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9446
CRH GeneProduct ensembl:ENSBTAG00000033128 CRF HUMAN PMID: 11854458
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1392
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
YWHAZ GeneProduct ensembl:ENSBTAG00000000236 PMID: 9861170 PMID: 1317796
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7534
CNN2 GeneProduct ensembl:ENSBTAG00000020764 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1265
PRKAR2A GeneProduct ensembl:ENSBTAG00000014205 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5576
GNB2 GeneProduct ensembl:ENSBTAG00000006495 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2783
GNG11 GeneProduct ensembl:ENSBTAG00000000820 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2791
OXTR GeneProduct ensembl:ENSBTAG00000019772 Sladek SM, Westerhausen-Larson A, Roberts JM.PMID: 10377025
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5021
IGFBP4 GeneProduct ensembl:ENSBTAG00000008611 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3487
RYR3 GeneProduct ensembl:ENSBTAG00000025642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6263
RGS10 GeneProduct ensembl:ENSBTAG00000002647 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6001
DGKZ GeneProduct ensembl:ENSBTAG00000013636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8525
RGS5 GeneProduct ensembl:ENSBTAG00000016341 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8490
ATP2A2 GeneProduct ensembl:ENSBTAG00000001398 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:488
IGFBP2 GeneProduct ensembl:ENSBTAG00000005596 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3485
RGS20 GeneProduct ensembl:ENSBTAG00000003454 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8601
GNAQ GeneProduct ensembl:ENSBTAG00000009789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
GNB5 GeneProduct ensembl:ENSBTAG00000003762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10681
YWHAE GeneProduct ensembl:ENSBTAG00000005664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7531
OXT GeneProduct ensembl:ENSBTAG00000008026 MGI:97453
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5020
PRKAR1A GeneProduct ensembl:ENSBTAG00000008621 KAP0 HUMAN
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5573
RGS9 GeneProduct ensembl:ENSBTAG00000017751 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8787
SFN GeneProduct ensembl:ENSBTAG00000009223 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2810
ADCY7 GeneProduct ensembl:ENSBTAG00000006208 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:113
ATF5 GeneProduct ensembl:ENSBTAG00000003457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22809
PLCG2 GeneProduct ensembl:ENSBTAG00000002103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5336
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
GNG5 GeneProduct ensembl:ENSBTAG00000008122 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2787
ADM GeneProduct ensembl:ENSBTAG00000021048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:133
RGS16 GeneProduct ensembl:ENSBTAG00000004305 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6004
ITPR3 GeneProduct ensembl:ENSBTAG00000013245 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3710
PRKD1 GeneProduct ensembl:ENSBTAG00000012789 KPCM HUMAN
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
ACTG1 GeneProduct ensembl:ENSBTAG00000006189 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:71
GNG8 GeneProduct ensembl:ENSBTAG00000017762 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:94235
RXFP2 GeneProduct ensembl:ENSBTAG00000015132 PMID: 11809971 LGR8 MOUSE
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:122042
GNB4 GeneProduct ensembl:ENSBTAG00000002767 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:59345
PRKAR1B GeneProduct ensembl:ENSBTAG00000046142 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5575
RGS19 GeneProduct ensembl:ENSBTAG00000021837 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10287
ACTB GeneProduct ensembl:ENSBTAG00000026199 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60
CORIN GeneProduct ensembl:ENSBTAG00000002199 MGI:97367
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10699
GABPB1 GeneProduct ensembl:ENSBTAG00000022801 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2553
PRKCD GeneProduct ensembl:ENSBTAG00000008719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
SP1 GeneProduct ensembl:ENSBTAG00000003021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667
GABPA GeneProduct ensembl:ENSBTAG00000019043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2551
ADCY6 GeneProduct ensembl:ENSBTAG00000005464 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112
GUCA2A GeneProduct ensembl:ENSBTAG00000007195 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2980
ITPR1 GeneProduct ensembl:ENSBTAG00000020455 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708
CAMK2B GeneProduct ensembl:ENSBTAG00000012653 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:816
CRHR1 GeneProduct ensembl:ENSBTAG00000002749 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1394
PDE4D GeneProduct ensembl:ENSBTAG00000000494 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5144
ETS2 GeneProduct ensembl:ENSBTAG00000009214 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2114
ATF3 GeneProduct ensembl:ENSBTAG00000008545 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:467
ADCY4 GeneProduct ensembl:ENSBTAG00000018419 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:196883
PLCD1 GeneProduct ensembl:ENSBTAG00000037726 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5333
RGS4 GeneProduct ensembl:ENSBTAG00000046277 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5999
RGS14 GeneProduct ensembl:ENSBTAG00000008497 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10636
SLC8A1 GeneProduct ensembl:ENSBTAG00000013861 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6546
GUCA2B GeneProduct ensembl:ENSBTAG00000007194 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2981
ARRB1 GeneProduct ensembl:ENSBTAG00000020485 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:408
GJA1 GeneProduct ensembl:ENSBTAG00000001835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2697
YWHAG GeneProduct ensembl:ENSBTAG00000004077 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7532
CACNB3 GeneProduct ensembl:ENSBTAG00000021808 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:784
CXCR7 GeneProduct ensembl:ENSBTAG00000018424 PMID: 10614663
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57007
IGFBP1 GeneProduct ensembl:ENSBTAG00000046768 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3484
PKIG GeneProduct ensembl:ENSBTAG00000005275 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11142
PDE4B GeneProduct ensembl:ENSBTAG00000008636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5142
GNGT1 GeneProduct ensembl:ENSBTAG00000002674 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2792
PKIA GeneProduct ensembl:ENSBTAG00000008150 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5569
YWHAQ GeneProduct ensembl:ENSBTAG00000002108 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10971
CREB3 GeneProduct ensembl:ENSBTAG00000011429 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10488
ACTC1 GeneProduct ensembl:ENSBTAG00000005714 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:70
IGFBP3 GeneProduct ensembl:ENSBTAG00000003994 Relaxin is a member of the Insulin Growth Factor family of proteins. IGFBP-3 binds IGFII preferentially. (SwissProt).
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3486
PLCG1 GeneProduct ensembl:ENSBTAG00000017584 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5335
GNAS GeneProduct ensembl:ENSBTAG00000017475 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2778
MAFF GeneProduct ensembl:ENSBTAG00000021435 OMIM: Inoue et al. (1994) demonstrated that the US-2 element in the promoter of the human oxytocin receptor gene (OXTR; 167055) binds specifically nuclear proteins from human myometrium at parturition. Using the US-2 element in a yeast 1-hybrid system to screen a human myometrium cDNA library, Kimura et al. (1999) isolated a full-length cDNA encoding the homolog of chicken MafF. Human MAFF encodes a deduced 164-amino acid protein with a predicted molecular mass of 17.8 kD. Like other small MAF proteins (e.g., MAFG, 602020), it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. Northern blot analysis showed a strong 2.6-kb signal in mRNA from term myometrium and from kidney, but not from nonpregnant myometrium. The MAFF protein is also preferentially expressed in term myometrium. The authors concluded that MAFF plays a role in OXTR gene upregulation at term.
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23764
PRKACA GeneProduct ensembl:ENSBTAG00000006642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566
ATF2 GeneProduct ensembl:ENSBTAG00000002295 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1386
GNG4 GeneProduct ensembl:ENSBTAG00000002908 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2786
ADCY9 GeneProduct ensembl:ENSBTAG00000016629 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:115
ACTA1 GeneProduct ensembl:ENSBTAG00000046332 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:58
GNB1 GeneProduct ensembl:ENSBTAG00000000215 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2782
MYL2 GeneProduct ensembl:ENSBTAG00000018369 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4633
RGS3 GeneProduct ensembl:ENSBTAG00000004499 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5998
ITPR2 GeneProduct ensembl:ENSBTAG00000002313 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3709
PLCB3 GeneProduct ensembl:ENSBTAG00000012510 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5331
CAMK2A GeneProduct ensembl:ENSBTAG00000020087 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:815
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene. Echetebu CO, Ali M, Izban MG, MacKay L, Garfield RE. PMID: 10421804
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
CREB1 GeneProduct ensembl:ENSBTAG00000005474 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
GUCY1A1 GeneProduct ensembl:ENSBTAG00000014576 PMID: 11854458
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2982

References

  1. Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium? Méhats C, Tanguy G, Dallot E, Cabrol D, Ferré F, Leroy MJ. J Clin Endocrinol Metab. 2001 Nov;86(11):5358–65. PubMed Europe PMC Scholia
  2. Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells. Aggelidou E, Hillhouse EW, Grammatopoulos DK. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3300–5. PubMed Europe PMC Scholia
  3. Identifying genetic networks underlying myometrial transition to labor. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, et al. Genome Biol. 2005;6(2):R12. PubMed Europe PMC Scholia