Senescence and autophagy in cancer (WP615)

Homo sapiens

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Senescense and autophagy pathways in cancer. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

For a description of pathway objects, see the WikiPathways Legend.

Authors

Shamith Samarajiwa , Kristina Hanspers , Thomas Kelder , Egon Willighagen , Martina Summer-Kutmon , Andika Tan , Alex Pico , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cancer pathway autophagy pathway cellular senescence pathway

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
PIP3(16:0/16:0) Metabolite hmdb:HMDB0010147
CDKN2A GeneProduct ncbigene:1029 ARF
MLL GeneProduct ncbigene:4297 ARF
IGFBP7 GeneProduct ncbigene:3490 ARF
IRF1 GeneProduct ncbigene:3659
SQSTM1 GeneProduct ncbigene:8878
IL6 GeneProduct ncbigene:3569
CDK4 GeneProduct ncbigene:1029 ARF
IL8 GeneProduct ncbigene:3576
CXCL14 GeneProduct ncbigene:9547 BRAK
CDKN1A GeneProduct ncbigene:1026
IGF1R GeneProduct ncbigene:3480
KIAA0652 GeneProduct ensembl:ENSG00000175224
SMAD3 GeneProduct ncbigene:4088
BMI1 GeneProduct ncbigene:648 ARF
LAMP1 GeneProduct ncbigene:3916
IL6R GeneProduct ncbigene:3570
SLC39A2 GeneProduct ncbigene:29986
ATG12 GeneProduct ncbigene:9140
ATG7 GeneProduct ncbigene:10533
CDKN1A GeneProduct ncbigene:1026 P21/CIP1/WAF1
BECN1 GeneProduct ncbigene:8678
PTEN GeneProduct ncbigene:5728
CREG1 GeneProduct ncbigene:8804
MAP2K1 GeneProduct ncbigene:5604 MEK
JUN GeneProduct ncbigene:3725 P21/CIP1/WAF1
GSN GeneProduct ncbigene:2934
ATG3 GeneProduct ncbigene:64422
COL1A1 GeneProduct ncbigene:1277
VTN GeneProduct ncbigene:7448
HMGA1 GeneProduct ncbigene:3159
CDKN1B GeneProduct ncbigene:1027 P27/KIP
SERPINB2 GeneProduct ncbigene:5055
CCL3 GeneProduct ncbigene:6348
ING1 GeneProduct ncbigene:3621
IRF5 GeneProduct ncbigene:3663
ATG16L1 GeneProduct ensembl:ENSG00000085978
INHBA GeneProduct ncbigene:3624
MMP14 GeneProduct ncbigene:4323
RB1CC1 GeneProduct ensembl:ENSG00000023287
IL24 GeneProduct ncbigene:11009
MAP1LC3A GeneProduct ncbigene:84557
COL10A1 GeneProduct ncbigene:1300 MKK3
ATG10 GeneProduct ncbigene:83734
IL1B GeneProduct ncbigene:3553
C/EBP-beta GeneProduct ncbigene:1051
CDKN2A GeneProduct ncbigene:1029 INK4a
CD44 GeneProduct ncbigene:960
ULK1 GeneProduct ncbigene:8408 ATG1
PIK3C3 GeneProduct ensembl:ENSG00000078142
IL1A GeneProduct ncbigene:3552
THBS1 GeneProduct ncbigene:7057
MAP1LC3C GeneProduct ncbigene:440738
IGFBP3 GeneProduct ncbigene:3486
CDC25B GeneProduct ncbigene:994
CDKN2A GeneProduct ncbigene:1029 P16/INK4a
GABARAPL1 GeneProduct ncbigene:23710
BRAF GeneProduct ncbigene:673
FRAP1 GeneProduct ncbigene:2475 mTOR
MDM2 GeneProduct ncbigene:4193
CXCL1 GeneProduct ncbigene:2919 GROa
PLAU GeneProduct ncbigene:5328 uPA
RB1 GeneProduct ncbigene:5925
LAMP2 GeneProduct ncbigene:3920
MAP2K3 GeneProduct ncbigene:5606 MKK3
ING2 GeneProduct ncbigene:3622
SH3GLB1 GeneProduct ncbigene:51100 BIF1
IGFBP5 GeneProduct ncbigene:3488
IFNB1 GeneProduct ncbigene:3456
IL6ST GeneProduct ncbigene:3572
SLC39A1 GeneProduct ncbigene:27173
AKT1S1 GeneProduct ensembl:ENSG00000204673
COL3A1 GeneProduct ncbigene:1281
SRC GeneProduct ncbigene:6714
FN1 GeneProduct ncbigene:2335
E2F1 GeneProduct ncbigene:1869
TP53 GeneProduct ncbigene:7157
MAPK14 GeneProduct ncbigene:1432 P38a
TGFB1 GeneProduct ncbigene:7040
GABARAP GeneProduct ncbigene:11337
MAP1LC3B GeneProduct ncbigene:81631
UVRAG GeneProduct ncbigene:7405
RSL1D1 GeneProduct ncbigene:26156
CDKN2A GeneProduct ncbigene:1029
BMP2 GeneProduct ncbigene:650 tPA
SLC39A3 GeneProduct ncbigene:29985
MAPK1 GeneProduct ncbigene:5594 ERK
IFNG GeneProduct ncbigene:3458
MAP2K6 GeneProduct ncbigene:5606 MEK6
INS GeneProduct ncbigene:3630 BRAK
SLC39A4 GeneProduct ncbigene:55630
IRF7 GeneProduct ncbigene:3665
RNASEL GeneProduct ncbigene:6041
PLAT GeneProduct ncbigene:5327 tPA
ATG14 GeneProduct ncbigene:22863
RAF1 GeneProduct ncbigene:5894
FKBP8 GeneProduct ensembl:ENSG00000105701
SMAD4 GeneProduct ncbigene:4089
GBL GeneProduct ensembl:ENSG00000167965
SERPINE1 GeneProduct ncbigene:5054 PAI1
AMBRA1 GeneProduct ncbigene:55626
CDK6 GeneProduct ncbigene:1029 ARF
GABARAPL2 GeneProduct ncbigene:11345
IL3 GeneProduct ncbigene:3562
IGF1 GeneProduct ncbigene:3479
TNFSF15 GeneProduct ncbigene:9966
CXCR2 GeneProduct ncbigene:1026
NFKB GeneProduct ncbigene:1026 P21/CIP1/WAF1
HRAS GeneProduct ncbigene:3265 H-RAS
ATG5 GeneProduct ncbigene:9474
IFI16 GeneProduct ncbigene:3428
PIK3C3 GeneProduct ncbigene:5289 VPS34
SPARC GeneProduct ncbigene:6678
PCNA GeneProduct ncbigene:5111
BCL2 GeneProduct ncbigene:596
CDK2 GeneProduct ncbigene:1029 ARF
GSK3B GeneProduct ncbigene:2932
ATG16 GeneProduct ncbigene:9474

References

  1. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, et al. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5874–8. PubMed Europe PMC Scholia
  2. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Kuilman T, Michaloglou C, Vredeveld LCW, Douma S, van Doorn R, Desmet CJ, et al. Cell. 2008 Jun 13;133(6):1019–31. PubMed Europe PMC Scholia
  3. MicroRNA 29b functions in acute myeloid leukemia. Garzon R, Heaphy CEA, Havelange V, Fabbri M, Volinia S, Tsao T, et al. Blood. 2009 Dec 17;114(26):5331–41. PubMed Europe PMC Scholia
  4. microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, et al. Blood. 2010 Apr 1;115(13):2630–9. PubMed Europe PMC Scholia
  5. miR-29b regulates migration of human breast cancer cells. Wang C, Bian Z, Wei D, Zhang J guo. Mol Cell Biochem. 2011 Jun;352(1–2):197–207. PubMed Europe PMC Scholia