EGF signaling in vulval development (WP2221)

Caenorhabditis elegans

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EGF signaling is a key pathway involved in vulval patterning. Vulval precursor cell patterning requires input and cooperation between both EGF LIN-3 graded signaling through LET-23 as well as a sequential, subordinate signal involving DSL ligands acting via LIN-12.

Authors

Karen Yook , Christine Chichester , Eric Weitz , and Stefan Raats

Activity

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Organisms

Caenorhabditis elegans

Communities

Annotations

Pathway Ontology

epidermal growth factor/neuregulin signaling pathway Ras mediated signaling pathway epidermal growth factor/neuregulin signaling pathway

Participants

Label Type Compact Identifier Comment
LIN-3 GeneProduct wormbase:F36H1.4
LET-23 GeneProduct wormbase:ZK1067.1
SEM-5 GeneProduct wormbase:C14F5.5
SOS-1 GeneProduct wormbase:T28F12.3
LET-60 GeneProduct wormbase:ZK792.6
LIN-45 GeneProduct wormbase:Y73B6A.5
MEK-2 GeneProduct wormbase:Y54E10BL.6
MPK-1 GeneProduct wormbase:F43C1.2
LIN-31 GeneProduct wormbase:K10G6.1
LIN-1 GeneProduct wormbase:C37F5.1
lin-39 GeneProduct wormbase:C07H6.7
egl-17 GeneProduct wormbase:F38G1.2

References

  1. Vulval development. Sternberg PW. WormBook. 2005 Jun 25;1–28. PubMed Europe PMC Scholia