EGF signaling in vulval development (WP2221)

Caenorhabditis elegans

EGF signaling is a key pathway involved in vulval patterning. Vulval precursor cell patterning requires input and cooperation between both EGF LIN-3 graded signaling through LET-23 as well as a sequential, subordinate signal involving DSL ligands acting via LIN-12.


Karen Yook , Christine Chichester , Eric Weitz , and Stefan Raats


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Caenorhabditis elegans



Pathway Ontology

epidermal growth factor/neuregulin signaling pathway Ras mediated signaling pathway epidermal growth factor/neuregulin signaling pathway


Label Type Compact URI Comment
LIN-3 GeneProduct wormbase:F36H1.4
LET-23 GeneProduct wormbase:ZK1067.1
SEM-5 GeneProduct wormbase:C14F5.5
SOS-1 GeneProduct wormbase:T28F12.3
LET-60 GeneProduct wormbase:ZK792.6
LIN-45 GeneProduct wormbase:Y73B6A.5
MEK-2 GeneProduct wormbase:Y54E10BL.6
MPK-1 GeneProduct wormbase:F43C1.2
LIN-31 GeneProduct wormbase:K10G6.1
LIN-1 GeneProduct wormbase:C37F5.1
lin-39 GeneProduct wormbase:C07H6.7
egl-17 GeneProduct wormbase:F38G1.2


  1. Vulval development. Sternberg PW. WormBook. 2005 Jun 25;1–28. PubMed Europe PMC Scholia