Lac-Phe pathway (WP5240)
Mus musculus
Mouse Lac-Phe pathway
Authors
Egon Willighagen and Eric WeitzActivity
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
classic metabolic pathway signaling pathwayDisease Ontology
obesity| Label | Type | Compact URI | Comment |
|---|---|---|---|
| L-phenylalanine | Metabolite | chebi:58095 | |
| (S)-lactate | Metabolite | chebi:16651 | |
| Lac-Phe | Metabolite | chebi:167456 | |
| Lac-Phe | Metabolite | chebi:167456 | |
| ABCC5 | GeneProduct | uniprot:Q9R1X5 | |
| CNDP2 | Protein | uniprot:Q9D1A2 |
References
- N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, et al. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6601–6. PubMed Europe PMC Scholia
- An exercise-inducible metabolite that suppresses feeding and obesity. Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, et al. Nature. 2022 Jun;606(7915):785–90. PubMed Europe PMC Scholia