Acetylcholine synthesis (WP175)

Mus musculus

Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.


Andrew Kwa , Thomas Kelder , James Bjork , Christine Chichester , Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz


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Mus musculus



Pathway Ontology

acetylcholine metabolic pathway


Label Type Compact URI Comment
Cytidine diphosphate choline Metabolite hmdb:HMDB0001413
Phosphatidylethanolamine Metabolite hmdb:HMDB0011420
Phosphorylcholine Metabolite hmdb:HMDB0001565
Acetylcholine Metabolite hmdb:HMDB0000895
Choline Metabolite hmdb:HMDB0000097
Glycerophosphocholine Metabolite hmdb:HMDB0000086
Phosphatidylcholine Metabolite hmdb:HMDB0000564
Pyruvate from Glycolysis Metabolite hmdb:HMDB0000243
Acetyl-CoA Metabolite hmdb:HMDB0001206
Acetate Metabolite hmdb:HMDB0000042
Choline Metabolite hmdb:HMDB0000097
Pcyt1a GeneProduct ncbigene:13026
Pdha2 GeneProduct ncbigene:18598
Ache GeneProduct ncbigene:11423
Pdha1 GeneProduct ncbigene:18597
Pemt GeneProduct ncbigene:18618
Chka GeneProduct ncbigene:12660
Chat GeneProduct ncbigene:12647


  1. Choline and cholinergic neurons. Blusztajn JK, Wurtman RJ. Science. 1983 Aug 12;221(4611):614–20. PubMed Europe PMC Scholia