Airway smooth muscle cell contraction (WP4962)

Homo sapiens

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Signal transduction pathways involved in airway smooth muscle cell contraction. Based on [https://www.resmedjournal.com/article/S0954-6111(08)00096-6/fulltext figure 1 from Belaia et al.].

Authors

Angelcymak , Kristina Hanspers , Eric Weitz , and Soukaina Boudllali

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

allergic asthma

Pathway Ontology

signaling pathway

Cell Type Ontology

bronchial smooth muscle cell

Participants
Query Drugst.One

Label Type Compact URI Comment
Ca2+ Metabolite chebi:29108
IP3 Metabolite chebi:16595
PIP2 Metabolite chebi:18348
DAG Metabolite chebi:18035
cADPR Metabolite chebi:31445
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
GTP Metabolite chebi:37565
GDP Metabolite chebi:17552
MYLK GeneProduct ensembl:ENSG00000065534
CD38 GeneProduct ensembl:ENSG00000004468
MYL GeneProduct ensembl:ENSG00000168530
ROCK1 GeneProduct ensembl:ENSG00000067900 Rho kinase
PLCB1 GeneProduct ensembl:ENSG00000182621
ITPR3 GeneProduct ensembl:ENSG00000096433
MLCP GeneProduct ensembl:ENSG00000213639
GDI GeneProduct ensembl:ENSG00000203879
GNAQ GeneProduct ensembl:ENSG00000156052
GCPR GeneProduct ensembl:ENSG00000169252 GPCR
PPP1R14A GeneProduct ensembl:ENSG00000167641
MYL GeneProduct ensembl:ENSG00000168530
RYR GeneProduct ensembl:ENSG00000196218
RHOA GeneProduct ensembl:ENSG00000067560
RHOA GeneProduct ensembl:ENSG00000067560
ROCK2 GeneProduct ensembl:ENSG00000134318 Rho kinase
ROCK1 GeneProduct ensembl:ENSG00000067900 Rho kinase
ROCK2 GeneProduct ensembl:ENSG00000134318 Rho kinase
Calmodulin Protein uniprot:G3V226
PKC Protein ensembl:L7RSM7
IL13 Protein ensembl:ENSG00000169194
MLCP Protein ensembl:ENSG00000213639 Myosin light chain phosphatase
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References

  1. Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma. Pelaia G, Renda T, Gallelli L, Vatrella A, Busceti MT, Agati S, et al. Respir Med. 2008 Aug;102(8):1173–81. PubMed Europe PMC Scholia