Amino acid metabolism pathway excerpt: histidine catabolism extension (WP4661)

Homo sapiens

This pathway was created based on findings from the bachelor thesis project by Kristin Koppelmaa which investigated vitamin D GWAS results. Thesis DOI: This pathway shows an excerpt of the WikiPathways amino acid metabolism (WP3925) pathway containing the segment between the metabolites histidine and glutamate that was extended. The proteins added to the conversion were AMDHD1 and UROC1. Although the HAL and FTCD proteins were included in the amino acid metabolism pathway previously, the lead SNP rs7487782 which exists in both HAL and AMDHD1, was added to the pathway and linked to these two genes. This variant was mapped to these genes during the analysis of a dataset originating from [ PMID: 29343764].


Kristin Koppelmaa , Egon Willighagen , Denise Slenter , and Eric Weitz


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Homo sapiens



Pathway Ontology

histidine degradation pathway


Label Type Compact URI Comment
Aconitate Metabolite hmdb:HMDB0000072
Oxaloacetate Metabolite hmdb:HMDB0000223
isocitrate Metabolite hmdb:HMDB0000193
Citrate Metabolite hmdb:HMDB0000094
Histidine Metabolite hmdb:HMDB0000177
Pyruvate Metabolite hmdb:HMDB0000243
Alanine Metabolite hmdb:HMDB0000161
Oxaloacetate Metabolite hmdb:HMDB0000223
Succinyl-CoA Metabolite hmdb:HMDB0001022
Succinate Metabolite hmdb:HMDB0000254
Fumarate Metabolite hmdb:HMDB0000134
Glutamate Metabolite hmdb:HMDB0000148
Malate Metabolite hmdb:HMDB0000156
2-oxo-glutarate Metabolite chebi:16810
UCA Metabolite chebi:30817 trans-urocanic acid
4I-5PROA Metabolite chebi:27384 trans-urocanic acid
NF-Glu Metabolite chebi:18327 trans-urocanic acid
GLUD1 GeneProduct ensembl:ENSG00000148672 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753
HAL GeneProduct ensembl:ENSG00000084110 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010
GPT2 GeneProduct ensembl:ENSG00000166123 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391
FTCD GeneProduct ensembl:ENSG00000160282 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962
UROC1 GeneProduct uniprot:Q96N76 Dimer with NAD+
AMDHD1 GeneProduct uniprot:Q96NU7


  1. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Jiang X, O’Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, et al. Nat Commun. 2018 Jan 17;9(1):260. PubMed Europe PMC Scholia