Selenium metabolism and selenoproteins (WP28)

Homo sapiens

* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase ** A selenoprotein database exists at: Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Susan Coort , Thomas Kelder , , Martijn Van Iersel , Egoyenechea , Kristina Hanspers , Chris Evelo , Andra Waagmeester , Alex Pico , Strand Life Sciences Pvt. Ltd , Egon Willighagen , Martina Summer-Kutmon , Lauren J. Dupuis , and Eric Weitz


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Homo sapiens




Pathway Ontology

selenoamino acid metabolic pathway


Label Type Compact URI Comment
MethylSelenol MeSeH Metabolite chemspider:389633
Selenite Metabolite hmdb:HMDB0011119
SeC Metabolite hmdb:HMDB0003288
Hydrogen selenide Metabolite hmdb:HMDB0011110
Selenophosphate Metabolite hmdb:HMDB0006407
SeMet Metabolite hmdb:HMDB0003966
SeC Metabolite hmdb:HMDB0003288
Selenate Metabolite chemspider:24657
Selenate Metabolite chemspider:24657
Selenite Metabolite hmdb:HMDB0011119
SeMet Metabolite hmdb:HMDB0003966
Rpl30 GeneProduct ncbigene:6156
SelO GeneProduct ncbigene:83642
Sp1 GeneProduct refseq:NP_612482
SBP2 GeneProduct uniprot:Q96T21
Sephs2 GeneProduct refseq:NP_036380
SelS GeneProduct ncbigene:55829
Secp43 GeneProduct ncbigene:54952
GPX6 GeneProduct ncbigene:257202
GPX1 GeneProduct ncbigene:2876
TXNRD3 GeneProduct ncbigene:114112
SBP2 GeneProduct uniprot:Q96T21
Pouf2f1 GeneProduct uniprot:P14859
CREM GeneProduct uniprot:Q03060
SepX1 GeneProduct ncbigene:51734
SelI GeneProduct ncbigene:85465
Sp3 GeneProduct ncbigene:6670
GPX3 GeneProduct ncbigene:2878
SelK GeneProduct ncbigene:58515
Sep15 GeneProduct uniprot:O60613
SEPN1 GeneProduct ncbigene:57190
JUN GeneProduct ensembl:ENSG00000177606
Fabp1 GeneProduct ncbigene:2168
eEFSec GeneProduct ncbigene:60678
SPS2 GeneProduct ncbigene:22928
Nfe2l2 GeneProduct refseq:NM_006164
DIO3 GeneProduct ncbigene:1735
TXNRD3 GeneProduct ncbigene:114112
Scly GeneProduct ncbigene:51540
SepW GeneProduct ncbigene:6415
SelT GeneProduct ncbigene:51714
NFKB-p65 GeneProduct ncbigene:5970
TXNRD1 GeneProduct ncbigene:7296
GPX4 GeneProduct ncbigene:2879
Sars GeneProduct uniprot:P49591
DIO2 GeneProduct ncbigene:1734
Sla GeneProduct ncbigene:51091
Cystathionine g-lyase GeneProduct refseq:NP_001893
DIO1 GeneProduct ncbigene:1733
TXNRD2 GeneProduct ncbigene:10587
Sephs1 GeneProduct uniprot:P49903
GPX2 GeneProduct ncbigene:2877
Pstk GeneProduct uniprot:Q8IV42
TXNRD1 GeneProduct ncbigene:7296
NFKB-p105 GeneProduct ncbigene:4790
SelM GeneProduct ncbigene:140606
SBP2 GeneProduct uniprot:Q96T21
SEPP1 GeneProduct ncbigene:6414
Sars2 GeneProduct ncbigene:54938
SelV GeneProduct ncbigene:348303
SelH GeneProduct ncbigene:280636
eEFSec GeneProduct ncbigene:60678
TXNRD2 GeneProduct ncbigene:10587
FOS GeneProduct ensembl:ENSG00000170345
Selenbp1 GeneProduct ncbigene:8991


  1. Temporal changes in tissue glutathione in response to chemical form, dose, and duration of selenium treatment. Relevance to cancer chemoprevention by selenium. Thompson HJ, Clement IP. Biol Trace Elem Res. 1991 Aug;30(2):163–73. PubMed Europe PMC Scholia
  2. Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection. Ip C, Hayes C. Carcinogenesis. 1989 May;10(5):921–5. PubMed Europe PMC Scholia
  3. Vitamin B6 enzymes participating in selenium amino acid metabolism. Soda K, Oikawa T, Esaki N. Biofactors. 1999;10(2–3):257–62. PubMed Europe PMC Scholia
  4. Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K. Commandeur JN, Andreadou I, Rooseboom M, Out M, de Leur LJ, Groot E, et al. J Pharmacol Exp Ther. 2000 Aug;294(2):753–61. PubMed Europe PMC Scholia
  5. Effectiveness of selenium supplements in a low-selenium area of China. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF. Am J Clin Nutr. 2005 Apr;81(4):829–34. PubMed Europe PMC Scholia
  6. Human selenoproteins at a glance. Gromer S, Eubel JK, Lee BL, Jacob J. Cell Mol Life Sci. 2005 Nov;62(21):2414–37. PubMed Europe PMC Scholia
  7. Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes. Small-Howard AL, Berry MJ. Biochem Soc Trans. 2005 Dec;33(Pt 6):1493–7. PubMed Europe PMC Scholia
  8. Biosynthesis of selenocysteine on its tRNA in eukaryotes. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, et al. PLoS Biol. 2007 Jan;5(1):e4. PubMed Europe PMC Scholia
  9. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Wang H, Zhang J, Yu H. Free Radic Biol Med. 2007 May 15;42(10):1524–33. PubMed Europe PMC Scholia
  10. From selenium to selenoproteins: synthesis, identity, and their role in human health. Papp LV, Lu J, Holmgren A, Khanna KK. Antioxid Redox Signal. 2007 Jul;9(7):775–806. PubMed Europe PMC Scholia
  11. The role of selenium in chronic disease. Boosalis MG. Nutr Clin Pract. 2008;23(2):152–60. PubMed Europe PMC Scholia