Cardiac progenitor differentiation (WP2406)

Homo sapiens

Factors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Nathan Salomonis , Kristina Hanspers , Alex Pico , Martina Summer-Kutmon , Anders Riutta , Eric Weitz , and Finterly Hu


last edited

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Homo sapiens



Pathway Ontology

regulatory pathway

Cell Type Ontology

cardiac muscle cell


Label Type Compact URI Comment
Retinoic acid Metabolite hmdb:HMDB0001852
INS GeneProduct ncbigene:3630
POU5F1 GeneProduct ensembl:ENSG00000204531
NANOG GeneProduct ensembl:ENSG00000111704
SOX2 GeneProduct ensembl:ENSG00000181449
LIN28A GeneProduct ensembl:ENSG00000131914
LIN28B GeneProduct ensembl:ENSG00000187772
ZFP42 GeneProduct ensembl:ENSG00000179059
THY1 GeneProduct ensembl:ENSG00000154096
SOX1 GeneProduct ensembl:ENSG00000182968
PAX6 GeneProduct ensembl:ENSG00000007372
SOX17 GeneProduct ensembl:ENSG00000164736
FOXA2 GeneProduct ensembl:ENSG00000125798
NCAM1 GeneProduct ensembl:ENSG00000149294
T GeneProduct ensembl:ENSG00000164458
ANPEP GeneProduct ensembl:ENSG00000166825
MIXL1 GeneProduct ensembl:ENSG00000185155
ROR2 GeneProduct ensembl:ENSG00000169071
WNT3A GeneProduct ensembl:ENSG00000154342
BMP4 GeneProduct ensembl:ENSG00000125378
INHBA GeneProduct ensembl:ENSG00000122641
GSK3B GeneProduct ensembl:ENSG00000082701
FGF2 GeneProduct ensembl:ENSG00000138685
MESP1 GeneProduct ensembl:ENSG00000166823
MESP2 GeneProduct ensembl:ENSG00000188095
KDR GeneProduct ensembl:ENSG00000128052
KIT GeneProduct ensembl:ENSG00000157404
CXCR4 GeneProduct ensembl:ENSG00000121966
PDGFRA GeneProduct ensembl:ENSG00000134853
NOTCH1 GeneProduct ensembl:ENSG00000148400
ISL1 GeneProduct ensembl:ENSG00000016082
NKX2-5 GeneProduct ensembl:ENSG00000183072
GATA4 GeneProduct ensembl:ENSG00000136574
TBX5 GeneProduct ensembl:ENSG00000089225
TBX20 GeneProduct ensembl:ENSG00000164532
MEF2C GeneProduct ensembl:ENSG00000081189
MAPK14 GeneProduct ensembl:ENSG00000112062
BMP1 GeneProduct ensembl:ENSG00000168487
NOG GeneProduct ensembl:ENSG00000183691
NODAL GeneProduct ensembl:ENSG00000156574
TGFB1 GeneProduct ensembl:ENSG00000105329
DKK1 GeneProduct ensembl:ENSG00000107984
MYH6 GeneProduct ensembl:ENSG00000197616
TNNT2 GeneProduct ensembl:ENSG00000118194
TNNI3 GeneProduct ensembl:ENSG00000129991
MYLK3 GeneProduct ensembl:ENSG00000140795
SIRPA GeneProduct ensembl:ENSG00000198053
MEF2C GeneProduct ensembl:ENSG00000081189
TNNT2 GeneProduct ensembl:ENSG00000118194
ACTC1 GeneProduct ensembl:ENSG00000159251
MYL2 GeneProduct ensembl:ENSG00000111245
SCN5A GeneProduct ensembl:ENSG00000183873
IRX4 GeneProduct ensembl:ENSG00000113430
IGF2 GeneProduct ensembl:ENSG00000167244
IGF1 GeneProduct ensembl:ENSG00000017427
WNT3A GeneProduct ensembl:ENSG00000154342
NRG1 GeneProduct ensembl:ENSG00000157168


  1. Preclinical animal models for testing iPSC/ESC-based heart therapy. Stillitano F, Karakikes I, Costa KD, Fish K, Hajjar RJ, Hulot JS. Drug Discovery Today: Disease Models [Internet]. 2012 Dec;9(4):e229–36. Available from: DOI Scholia
  2. Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Burridge PW, Keller G, Gold JD, Wu JC. Cell Stem Cell. 2012 Jan 6;10(1):16–28. PubMed Europe PMC Scholia