Ebstein-Barr virus LMP1 signaling (WP262)

Homo sapiens

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Latent membrane protein 1 (LMP1) of the Ebstein-Barr Virus (EBV) elicits its oncogenice effects through the activation of several downstream pathways suchs as Pi3K/akt, IRF4, and NFkB pathways. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP262 CPTAC Assay Portal]

Authors

Thomas Kelder , Martijn Van Iersel , Kristina Hanspers , Christine Chichester , Alex Pico , Zahra Roudbari , Martina Summer-Kutmon , Roelod , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Epstein-Barr virus infection pathway oxidative phosphorylation pathway

Participants
Query Drugst.One

Label Type Compact Identifier Comment
LMP1 GeneProduct ensembl:ENSG00000196923
TRADD GeneProduct ensembl:ENSG00000102871
IRAK1 GeneProduct ensembl:ENSG00000184216
TRAF1 GeneProduct ensembl:ENSG00000056558
NIK GeneProduct ensembl:ENSG00000006062
IKK-alpha GeneProduct ncbigene:1147
p100 GeneProduct ensembl:ENSG00000077150
p65 GeneProduct ensembl:ENSG00000173039
p52 GeneProduct ensembl:ENSG00000077150
p65 GeneProduct ensembl:ENSG00000173039
MAP3K7 GeneProduct ensembl:ENSG00000135341
TAB1 GeneProduct ensembl:ENSG00000135341
MAP3K3 GeneProduct ensembl:ENSG00000198909
TRAF6 GeneProduct ensembl:ENSG00000175104
IKK-gamma GeneProduct ensembl:ENSG00000269335
IKK-alpha GeneProduct ensembl:ENSG00000213341
IKK-beta GeneProduct ensembl:ENSG00000104365
HSP90 GeneProduct ncbigene:3320
p38 GeneProduct ensembl:ENSG00000100030
p65 GeneProduct ensembl:ENSG00000173039
p50 GeneProduct ensembl:ENSG00000109320
JNK GeneProduct ensembl:ENSG00000107643
I-Kappa-B GeneProduct ensembl:ENSG00000100906
p50 GeneProduct ensembl:ENSG00000109320
p65 GeneProduct ensembl:ENSG00000173039
p65 GeneProduct ensembl:ENSG00000173039
I-Kappa-B GeneProduct ensembl:ENSG00000100906
p50 GeneProduct ensembl:ENSG00000109320
IL8 GeneProduct ensembl:ENSG00000169429
IFNB GeneProduct ensembl:ENSG00000171855
CCL20 GeneProduct ensembl:ENSG00000115009
TNF GeneProduct ensembl:ENSG00000232810
CCL5 GeneProduct ensembl:ENSG00000271503
p50/p52 GeneProduct ensembl:ENSG00000109320
p65 GeneProduct ensembl:ENSG00000173039

References

  1. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. J Biol Chem. 2006 Mar 24;281(12):7863–72. PubMed Europe PMC Scholia
  2. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
  3. Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis. Lee JS, Lee JY, Son JW, Oh JH, Shin DM, Yuk JM, et al. Scand J Immunol. 2008 Jan;67(1):77–85. PubMed Europe PMC Scholia
  4. Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia